SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE
KUHAR M, ROTH R, AGHAJANIAN G. SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE. Journal Of Pharmacology And Experimental Therapeutics 1972, 181: 36-45. PMID: 4552069, DOI: 10.1016/s0022-3565(25)29173-x.Peer-Reviewed Original ResearchConceptsConcentrations of 5-HTRaphe lesionsSynaptosomal uptakeUptake of 3H-5-HTTricyclic agent imipramineMidbrain raphe lesionsNerve endingsMidbrain raphe nucleiTryptophan hydroxylase activityTime coursePlacement of lesionsRaphe nucleusSerotonin uptakeRaphe neuronsLesioned animalsUptake activityMidbrain areaL-norepinephrineLesionsHydroxylase activityRapheIncubation mediumForebrainL-tryptophanAnimals
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