2024
Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils
Buchheit K, Shaw D, Chupp G, Lehtimaki L, Heffler E, Finney‐Hayward T, Zangrilli J, Kwiatek J, Siddiqui S, Roufosse F, Thamboo A, West N, Vichiendilokkul A, Hellings P, Peters A, Howarth P. Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils. Allergy 2024, 79: 2662-2679. PMID: 39359069, DOI: 10.1111/all.16303.Peer-Reviewed Original ResearchConceptsAnti-IL-5 therapyType 2 inflammationIL-5Airway type 2 inflammationT regulatory cellsInnate lymphoid cellsInterleukin (IL)-5Relevant to disease pathogenesisSurvival of eosinophilsLower airway diseaseEosinophil-associated diseasesEffector cellsEosinophil depletionTargeted therapyClinical benefitLymphoid cellsPlasma cellsAirway diseaseInterleukin-5Epithelial cellsTherapeutic effectMast cellsDisease pathogenesisEosinophilsTissue damage
2023
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.Peer-Reviewed Original Research
2000
Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks
O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.Peer-Reviewed Original Research
1999
Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.Peer-Reviewed Original ResearchConceptsOPN-null miceMycobacterial infectionAntigen-specific T-cell immunityMycobacterium bovis BCG infectionBacterial loadClearance of mycobacteriaT cell immunityGamma interferon productionWild-type miceNitric oxide productionMediators of resistanceAbility of osteopontinElevated bacterial loadHeavy bacterial loadMycobacterium bovis BCGBCG infectionSevere infectionsHost protectionMouse modelMacrophage defectHost responseInterferon productionCytokine osteopontinOxide productionInfection
1997
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.Peer-Reviewed Original ResearchMeSH KeywordsBronchopneumoniaCell LineChemokine CCL4Chemotactic FactorsCytokinesDNA PrimersFerritinsGene LibraryGranulomaHumansImmunohistochemistryMacrophage Inflammatory ProteinsMacrophagesMacrophages, AlveolarMycobacterium bovisMycobacterium tuberculosisOsteopontinPolymerase Chain ReactionSialoglycoproteinsSilicosisTranscription, GeneticTuberculosisConceptsHuman genome sequenceMacrophage cDNA libraryHost cell genesGranuloma formationOsteopontin gene expressionPrimary human alveolar macrophagesGenome sequenceMononuclear cell infiltrateMycobacterium tuberculosis infectionHost genesCDNA libraryCell genesGene expressionHuman alveolar macrophagesAssociation of osteopontinGenesExtracellular matrixPathologic responseCell infiltrateTuberculosis infectionGranulomatous pathologyChronic inflammationGranulomatous diseaseChemoattractant cytokinesMacrophage chemoattractant
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