2020
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning
Unger E, Keller J, Altermatt M, Liang R, Matsui A, Dong C, Hon O, Yao Z, Sun J, Banala S, Flanigan M, Jaffe D, Hartanto S, Carlen J, Mizuno G, Borden P, Shivange A, Cameron L, Sinning S, Underhill S, Olson D, Amara S, Temple Lang D, Rudnick G, Marvin J, Lavis L, Lester H, Alvarez V, Fisher A, Prescher J, Kash T, Yarov-Yarovoy V, Gradinaru V, Looger L, Tian L. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 2020, 183: 1986-2002.e26. PMID: 33333022, PMCID: PMC8025677, DOI: 10.1016/j.cell.2020.11.040.Peer-Reviewed Original Research
2013
Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder
Porton B, Greenberg B, Askland K, Serra L, Gesmonde J, Rudnick G, Rasmussen S, Kao H. Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Translational Psychiatry 2013, 3: e259-e259. PMID: 23695234, PMCID: PMC3669922, DOI: 10.1038/tp.2013.35.Peer-Reviewed Original ResearchConceptsExcellent candidate geneObsessive-compulsive disorderNeuronal glutamate transporterGenomic levelInternal promoterCandidate genesPartial colocalizationTransporter geneGene expressionGenetic studiesGlutamate uptakeEAAC1 transporterPrimary promoterEAAC1 proteinGlutamate transporter geneGenesPhysiological regulatorIsoformsTranscriptsExon 2Glutamate transportersGlutamatergic gene expressionPromoterPotential clinical utilityNeuronal glutamate transporter gene
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