2020
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning
Unger E, Keller J, Altermatt M, Liang R, Matsui A, Dong C, Hon O, Yao Z, Sun J, Banala S, Flanigan M, Jaffe D, Hartanto S, Carlen J, Mizuno G, Borden P, Shivange A, Cameron L, Sinning S, Underhill S, Olson D, Amara S, Temple Lang D, Rudnick G, Marvin J, Lavis L, Lester H, Alvarez V, Fisher A, Prescher J, Kash T, Yarov-Yarovoy V, Gradinaru V, Looger L, Tian L. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 2020, 183: 1986-2002.e26. PMID: 33333022, PMCID: PMC8025677, DOI: 10.1016/j.cell.2020.11.040.Peer-Reviewed Original Research
2013
Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder
Porton B, Greenberg B, Askland K, Serra L, Gesmonde J, Rudnick G, Rasmussen S, Kao H. Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Translational Psychiatry 2013, 3: e259-e259. PMID: 23695234, PMCID: PMC3669922, DOI: 10.1038/tp.2013.35.Peer-Reviewed Original ResearchConceptsExcellent candidate geneObsessive-compulsive disorderNeuronal glutamate transporterGenomic levelInternal promoterCandidate genesPartial colocalizationTransporter geneGene expressionGenetic studiesGlutamate uptakeEAAC1 transporterPrimary promoterEAAC1 proteinGlutamate transporter geneGenesPhysiological regulatorIsoformsTranscriptsExon 2Glutamate transportersGlutamatergic gene expressionPromoterPotential clinical utilityNeuronal glutamate transporter gene
2012
Cyclic GMP-dependent Stimulation of Serotonin Transport Does Not Involve Direct Transporter Phosphorylation by cGMP-dependent Protein Kinase*
Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G. Cyclic GMP-dependent Stimulation of Serotonin Transport Does Not Involve Direct Transporter Phosphorylation by cGMP-dependent Protein Kinase*. Journal Of Biological Chemistry 2012, 287: 36051-36058. PMID: 22942288, PMCID: PMC3476273, DOI: 10.1074/jbc.m112.394726.Peer-Reviewed Original ResearchConceptsCGMP-dependent protein kinaseProtein kinaseATP analogUnidentified protein kinasesWild-type kinaseMitogen-activated protein kinaseP38 mitogen-activated protein kinasePhosphorylation site sequencePKG-dependent phosphorylationModel peptide substratesTransporter phosphorylationKinase cascadePhosphorylation sitesWT kinaseDirect substrateProtein substratesResidue mutantsSerotonin transporterPeptide library screeningSite sequenceP38 inhibitorLibrary screeningKinasePeptide substratesCultured cells
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