2010
Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
Swenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, 3: 1-10. DOI: 10.2147/ceg.s12187482.Peer-Reviewed Original ResearchInflammatory bowel diseaseAllogeneic hematopoietic transplantationHematopoietic stem cellsTreatment of inflammatory bowel diseaseHematopoietic transplantationPredisposition to inflammatory bowel diseaseHost immune responseMesenchymal stem cellsStem cellsGenetic predisposition to inflammatory bowel diseaseSystemically infused mesenchymal stem cellsFistulas associated with Crohn's diseaseGraft-versus-host diseaseImmune responseHematopoietic stem cell transplantationBowel diseaseAutologous hematopoietic transplantationGraft-versus-hostStem cell transplantationDownregulate host immune responsesRisk of complicationsStem cell therapyStem cell therapy applicationsAutologous hematopoietic reconstitutionBlood cell linesStem cell therapeutics: potential in the treatment of inflammatory bowel disease
Swenson E, Theise N. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clinical And Experimental Gastroenterology 2010, Volume 3: 1-10. PMID: 21694840, PMCID: PMC3108654, DOI: 10.2147/ceg.s6836.Peer-Reviewed Original ResearchInflammatory bowel diseaseAllogeneic hematopoietic transplantationHost immune responseHematopoietic transplantationMesenchymal stem cellsBlood cell linesBowel diseaseImmune responseGenetic predispositionStem cellsLarge clinical trialsAutologous hematopoietic transplantationAutologous hematopoietic reconstitutionHost diseaseCrohn's diseaseMucosal immunityClinical trialsHematopoietic reconstitutionSmall seriesTransplantationGreater riskCell therapyDiseaseDonor cellsBaseline state
2009
Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells
Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells. Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsHepatocyte growth factorMSC chemotaxisCellular injuryMesenchymal stem cellsAdenosine concentrationRegulation of HGFInhibition of HGFEffects of adenosineSite of injuryBone marrow-derived mesenchymal stem cellsHepatocyte-specific genesHigh adenosine concentrationsHuman marrow-derived mesenchymal stem cellsAdenosine monophosphateBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsConcentration of adenosineLiver injuryCytosolic calcium signalingStress fiber formationA2A receptorsHepatocyte-like cellsCyclic adenosine monophosphate
2008
Chimeric mice reveal clonal development of pancreatic acini, but not islets
Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.Peer-Reviewed Original ResearchConceptsStem/progenitor cellsMultiple progenitorsAdult mouse small intestineMale ES cellsProgenitor cellsFemale blastocystsCrypt stem cellsClonal descendantsES cellsY chromosomeChimeric miceFemale cellsIntestinal crypt stem cellsExocrine pancreatic aciniFemale epithelial cellsClonal developmentStem cellsSitu hybridizationMouse small intestineEpithelial cellsIntestinal cryptsProgenitorsPancreatic aciniCellsPancreatic islets
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