2020
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Vormstein-Schneider D, Lin J, Pelkey K, Chittajallu R, Guo B, Arias-Garcia M, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken T, Smith J, Ibrahim L, Mastro K, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi G, Gorissen B, Yuan X, Zaghloul K, Devinsky O, Sabatini B, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain C, Fishell G, Dimidschstein J. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans. Nature Neuroscience 2020, 23: 1629-1636. PMID: 32807948, PMCID: PMC8015416, DOI: 10.1038/s41593-020-0692-9.Peer-Reviewed Original ResearchConceptsRecombinant adeno-associated virus vectorAdeno-associated virus vectorVasoactive intestinal peptide-expressing interneuronsClasses of neuronsGene regulatory elementsGene SCN1AViral toolsNeuronal subtypesCerebral cortexViral manipulationTherapeutic interventionsVertebrate speciesNon-human primatesVirus vectorsGene expressionInterneuronsBrain regionsCircuit manipulationsExquisite specificityParvalbuminRegulatory landscapeNeuronsSCN1ASubtypesMice
2019
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Favuzzi E, Deogracias R, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa A, F Maraver E, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Science 2019, 363: 413-417. PMID: 30679375, DOI: 10.1126/science.aau8977.Peer-Reviewed Original ResearchConceptsCortical inhibitory circuitsInhibitory circuitsClasses of GABAergic interneuronsInvestigate transcriptional dynamicsClasses of interneuronsConnectivity patternsAxon initial segmentGABAergic interneuronsMammalian cerebral cortexTranscriptional dynamicsCortical interneuronsPyramidal cellsSynapse specificityPostnatal developmentInterneuron diversityInterneuronsCerebral cortexMolecular mechanismsConnectivity motifsSynaptic moleculesBrain functionMolecular programsNeuronal connectivityInformation processingFunctional networks