2025
Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study
Amat J, Dudgeon S, Cheemarla N, Watkins T, Green A, Young H, Peaper D, Landry M, Schulz W, Foxman E. Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study. EBioMedicine 2025, 117: 105820. PMID: 40543450, PMCID: PMC12216728, DOI: 10.1016/j.ebiom.2025.105820.Peer-Reviewed Original ResearchRespiratory virus infectionsHigh-risk settingsRespiratory infectionsRoutine screeningVirus infectionViral respiratory infectionsLow viral loadViral prevalenceGold standard testRespiratory virus diagnosisNasal biomarkersViral loadPractical screening testNasal mucosaRespiratory virusesHost biomarkersChemotherapeutic drugsVirus-positiveBiomarker testingNasopharyngeal samplesCXCL10Medical recordsScreening testElectronic medical recordsPCR panel
2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2023
Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study
Cheemarla N, Hanron A, Fauver J, Bishai J, Watkins T, Brito A, Zhao D, Alpert T, Vogels C, Ko A, Schulz W, Landry M, Grubaugh N, van Dijk D, Foxman E. Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study. The Lancet Microbe 2023, 4: e38-e46. PMID: 36586415, PMCID: PMC9835789, DOI: 10.1016/s2666-5247(22)00296-8.Peer-Reviewed Original ResearchConceptsRespiratory virus panelPg/mLCXCL10 concentrationsSARS-CoV-2Bacterial pathobiontsRespiratory virusesSARS-CoV-2 negative samplesViral respiratory infectionsSARS-CoV-2 positive samplesClinical virology laboratoryHealth care systemVirus-positive samplesQuantitative RT-PCRInfluenza C virusSymptomatic patientsRespiratory infectionsSeasonal coronavirusesNasopharyngeal swabsVirus panelC virusCommon virusesCXCL10Host responseInterferon responseVirology laboratory
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply