2024
“Peace of Mind” After Mastectomy: A Scoping Review
Hamid S, Bakkila B, Schultz K, Grimshaw A, Gunderson C, Godfrey E, Lee C, Berger E, Rosenberg S, Greenup R. “Peace of Mind” After Mastectomy: A Scoping Review. Annals Of Surgical Oncology 2024, 31: 5168-5179. PMID: 38717543, DOI: 10.1245/s10434-024-15360-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsContralateral prophylactic mastectomyUnilateral mastectomyBreast-conserving therapyAverage-risk womenInclusion criteriaPsychosocial well-beingProspective cohort studyBackgroundMany womenProphylactic mastectomyScoping reviewMethodsNine databasesWhite/Caucasian womenCohort studyStudy samplePostoperative time pointsStatistically significant resultsRelevant articlesWell-beingAnxietyResultsThe inclusion criteriaWomenMastectomySignificant resultsSurgical choiceSurgical decision
2022
Trends in Survival for Pediatric Transplantation.
Hickner B, Anand A, Godfrey E, Dunson J, Reul R, Cotton R, Galvan N, O'Mahony C, Goss J, Rana A. Trends in Survival for Pediatric Transplantation. Pediatrics 2022, 149 PMID: 35079811, DOI: 10.1542/peds.2020-049632.Peer-Reviewed Original ResearchConceptsTreat survivalKidney transplantPosttransplant survivalHeart transplantPediatric transplantationMultivariable Cox regressionPercentage of patientsKaplan-Meier methodLog-rank testLiver transplantPosttransplant outcomesTreat analysisTransplant ratesCox regressionDonor poolPatient's perspectiveTransplantPatient careStudy periodΧ2 testLiverSurvivalTransplantationSignificant increaseChildren
2021
Disease-Specific Variation in Intention to Treat (ITT) Survival for Lung Transplant Candidates in the Lung Allocation Score (LAS) Era
Godfrey E, Garcha P, Carrott P, Liao K, Shafii A, Rana A, Segraves J, Li G, Kumar A, Loor G. Disease-Specific Variation in Intention to Treat (ITT) Survival for Lung Transplant Candidates in the Lung Allocation Score (LAS) Era. 2021, a1780-a1780. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1780.Peer-Reviewed Original Research
2020
Survival on the Heart Transplant Waiting List
Bakhtiyar SS, Godfrey EL, Ahmed S, Lamba H, Morgan J, Loor G, Civitello A, Cheema FH, Etheridge WB, Goss J, Rana A. Survival on the Heart Transplant Waiting List. JAMA Cardiology 2020, 5: 1227-1235. PMID: 32785619, PMCID: PMC7675100, DOI: 10.1001/jamacardio.2020.2795.Peer-Reviewed Original ResearchConceptsVentricular assist deviceHeart transplant waiting listList survivalTransplant waiting listWaiting listMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisHeart transplantation waiting listAdjusted survival analysisHazards regression analysisTransplantation waiting listWait-listed candidatesCandidate risk factorsHeart transplantationList mortalityUNOS databaseClinical improvementHeart transplantPrimary outcomeAdjusted analysisSurvival outcomesKaplan-MeierPatient groupUnited NetworkA Data-Driven Approach to Defining the Volume-Outcome Relationship in Lung Transplantation
Godfrey E, Frankel W, Rana A, Liao K, Loor G, Suarez E. A Data-Driven Approach to Defining the Volume-Outcome Relationship in Lung Transplantation. The Journal Of Heart And Lung Transplantation 2020, 39: s364. DOI: 10.1016/j.healun.2020.01.445.Peer-Reviewed Original ResearchHigh-volume centersStratum-specific likelihood ratiosLung transplantationVolume centersVolume strataLung transplant centersOrgan Sharing databaseExtended criteria donorsVolume-outcome relationshipEx vivo perfusionMajority of transplantsLTx casesLTx centersLung transplantIschemic timeFinal cohortOlder recipientsPrimary outcomeSharing databaseSubstantial morbidityTransplant centersRecipient outcomesYear mortalityPatient survivalUnited NetworkData-Driven Volume Thresholds Predictive of Improved Outcomes after Orthotopic Heart Transplantation
Frankel W, Godfrey E, Suarez E, Rana A, Shafii A, Loor G, Liao K. Data-Driven Volume Thresholds Predictive of Improved Outcomes after Orthotopic Heart Transplantation. The Journal Of Heart And Lung Transplantation 2020, 39: s363. DOI: 10.1016/j.healun.2020.01.441.Peer-Reviewed Original ResearchOrthotopic heart transplantationHigh-volume centersStratum-specific likelihood ratio (SSLR) analysisVolume centersHeart transplantationVolume strataImproved outcomesIntra-aortic balloon pumpImproved early outcomePost-transplant dialysisOrgan Sharing databaseLow-volume centersYears of ageLow-volume counterpartsComplex surgical careHalf of recipientsOHT casesPreoperative characteristicsPostoperative outcomesBalloon pumpFinal cohortPrimary outcomeSharing databaseMedication usageEarly mortalityResponse to “Reply to: ‘The decreasing predictive power of MELD in an era of changing etiology of liver disease’”
Godfrey EL, Malik TH, Lai JC, Mindikoglu AL, Galván NTN, Cotton RT, O'Mahony CA, Goss JA, Rana A. Response to “Reply to: ‘The decreasing predictive power of MELD in an era of changing etiology of liver disease’”. American Journal Of Transplantation 2020, 20: 903-904. PMID: 31943742, DOI: 10.1111/ajt.15783.Peer-Reviewed Original Research
2019
The decreasing predictive power of MELD in an era of changing etiology of liver disease
Godfrey EL, Malik TH, Lai JC, Mindikoglu AL, Galván NTN, Cotton RT, O'Mahony CA, Goss JA, Rana A. The decreasing predictive power of MELD in an era of changing etiology of liver disease. American Journal Of Transplantation 2019, 19: 3299-3307. PMID: 31394020, DOI: 10.1111/ajt.15559.Peer-Reviewed Original ResearchConceptsMELD scoreLiver diseaseNon-alcoholic fatty liver diseaseHCV-positive patientsHCV-positive statusLab-MELD scoreAlcoholic liver diseaseFatty liver diseaseBest supportive therapyDe-identified dataLiver transplantLiver transplantationMELD eraFailure etiologyWaitlist deathsSupportive therapyUnited NetworkEtiology of diseaseOrgan SharingConcordance statisticDiseaseMortalityEtiologyMELDPatientsThe Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation
Godfrey E, Kueht M, Rana A, Frazier O. The Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation. Texas Heart Institute Journal 2019, 46: 199-202. PMID: 31708703, PMCID: PMC6827470, DOI: 10.14503/thij-17-6544.Peer-Reviewed Original ResearchConceptsHeterotopic heart transplantationHeart transplantationOrthotopic transplantationHeart failureHuman leukocyte antigen mismatchesIntra-aortic balloon pumpIdiopathic nonischemic cardiomyopathyOrthotopic heart transplantationEnd-stage heart failureManagement of end-stage heart failureMechanical circulatory supportCoronary artery stentingAntigen mismatchesNonischemic cardiomyopathyGraft survivalMedical therapyBalloon pumpHeterotopic allograftsCardiac supportArtery stentingMechanical circulatory assist devicesPoor histocompatibilityTransplantationHeart functionNative heart functionAn Infertile Couple's Long and Expensive Path to Varicocele Repair.
Balasubramanian A, Thirumavalavan N, Scovell J, Lo J, Ji B, Godfrey EL, Pastuszak AW, Lipshultz LI. An Infertile Couple's Long and Expensive Path to Varicocele Repair. Urology 2019, 124: 131-135. PMID: 30359710, PMCID: PMC6387868, DOI: 10.1016/j.urology.2018.10.021.Peer-Reviewed Original ResearchOutcomes in Solid-Organ Transplantation: Success and Stagnation
Rana A, Godfrey EL. Outcomes in Solid-Organ Transplantation: Success and Stagnation. Texas Heart Institute Journal 2019, 46: 75-76. PMID: 30833851, PMCID: PMC6379008, DOI: 10.14503/thij-18-6749.Peer-Reviewed Original ResearchLiver Transplantation for Alcoholic Liver Disease An Update
Godfrey EL, Stribling R, Rana A. Liver Transplantation for Alcoholic Liver Disease An Update. Clinics In Liver Disease 2019, 23: 127-139. PMID: 30454827, DOI: 10.1016/j.cld.2018.09.007.Peer-Reviewed Original ResearchConceptsAlcoholic liver diseaseLiver diseaseAbstinence periodBetter long-term outcomesLiver disease burdenSevere alcoholic hepatitisOverall favorable outcomeLong-term outcomesAlcohol use treatmentUnique health concernsMinimum abstinence periodPosttransplantation riskAlcoholic hepatitisLiver transplantationMetabolic complicationsEarly transplantationDisease burdenFavorable outcomeBetter outcomesHealth concernUse treatmentTransplantationOutcomesDiseaseSelection criteria
2018
MELD-Na (the new MELD) and peri-operative outcomes in emergency surgery
Godfrey E, Kueht M, Rana A, Awad S. MELD-Na (the new MELD) and peri-operative outcomes in emergency surgery. The American Journal Of Surgery 2018, 216: 407-413. PMID: 29871737, DOI: 10.1016/j.amjsurg.2018.04.017.Peer-Reviewed Original ResearchConceptsPeri-operative outcomesPost-operative complicationsEmergency surgeryDischarged to homeMELD-NaOutcomes of cirrhotic patientsPredictors of discharge to homeMELD-Na scoreRetrospective chart reviewNon-transplant surgeryPeri-operative riskCirrhotic patientsSerum sodiumChart reviewScore thresholdIncreased riskSurgeryLife-savingPatientsMultivariate regressionNegative predictorCirrhosisComplicationsOutcomesRisk threshold
2016
Deliberate liver transplantation for fulminant liver failure with acute lymphoblastic leukemia
Kueht M, Cotton R, Godfrey E, Dreyer Z, Fishman D, Goss J. Deliberate liver transplantation for fulminant liver failure with acute lymphoblastic leukemia. Liver Transplantation 2016, 22: 1724-1726. PMID: 27597163, DOI: 10.1002/lt.24627.Peer-Reviewed Original ResearchValve Interstitial Cells Act in a Pericyte Manner Promoting Angiogensis and Invasion by Valve Endothelial Cells
Arevalos C, Berg J, Nguyen J, Godfrey E, Iriondo C, Grande-Allen K. Valve Interstitial Cells Act in a Pericyte Manner Promoting Angiogensis and Invasion by Valve Endothelial Cells. Annals Of Biomedical Engineering 2016, 44: 2707-2723. PMID: 26905695, PMCID: PMC4983529, DOI: 10.1007/s10439-016-1567-9.Peer-Reviewed Original ResearchConceptsValvular interstitial cellsValve endothelial cellsROCK-dependent mannerInvasion of MatrigelVasculogenic networksCell organizationCo-culturePhenotypic changesInvasive spheroidsCalcific aortic valve diseaseROCK activityControl cellsCell typesProgression of calcific aortic valve diseaseValve cellsCell culturesCell-activeEndothelial cellsPhenotypeCellsLong-term cultureSpheroid formationPericyte-like phenotypeBasal levelsInvasion
2015
Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors
Arevalos C, Walborn A, Rupert A, Berg J, Godfrey E, Nguyen J, Grande-Allen K. Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors. Microvascular Research 2015, 98: 108-118. PMID: 25660064, PMCID: PMC4974942, DOI: 10.1016/j.mvr.2015.01.008.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmidesAminoquinolinesAnimalsAortic ValveCell CommunicationCell MovementCell TransdifferentiationEndothelial CellsImage Processing, Computer-AssistedImmunohistochemistryPlatelet Endothelial Cell Adhesion Molecule-1Protein Kinase InhibitorsProto-Oncogene Proteins c-aktPyridinesPyrimidinesrho-Associated KinasesSwineWound HealingConceptsRho familyRho family of GTPasesRac1 inhibitionFamily of GTPasesSerine-threonine protein kinaseValve endothelial cellsCell-cell adhesionScratch wound healing assayNSC-23766Rac inhibitorResponse to small-molecule inhibitorsCytoskeletal reorientationWound healing assayProtein kinaseRac1Small molecule inhibitorsCell numberRac1 inhibitorCell migrationCell biologyEndothelial cellsY-27632Inhibited migrationHealing assayMolecule inhibitors
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