2024
Nonlinearity of the Inverse Relationship between High-Density Lipoprotein (HDL) Cholesterol and Incident Cardiovascular Risk: Is It Time to Revisit the “HDL Hypothesis”?
Hashem C, Altin S, Guyton J, Boden W. Nonlinearity of the Inverse Relationship between High-Density Lipoprotein (HDL) Cholesterol and Incident Cardiovascular Risk: Is It Time to Revisit the “HDL Hypothesis”? Journal Of Clinical Lipidology 2024 PMID: 39934033, DOI: 10.1016/j.jacl.2024.12.009.Peer-Reviewed Original ResearchLow HDL-CHDL-C levelsHDL-CAssociated with atherosclerotic cardiovascular diseaseRandomized controlled trialsLow levels of high-density lipoprotein cholesterolLow HDL-C levelsLevels of high-density lipoprotein cholesterolIncident cardiovascular riskLevels of HDL-CReduce ASCVD eventsHigh-density lipoprotein cholesterolOptimal risk stratificationHigh-density lipoprotein (HDLStatin-based therapyHDL hypothesisAtherosclerotic cardiovascular diseaseLipoprotein (HDLRisk-enhancing factorsIncident cardiovascular eventsCholesterol guidelinesRisk stratificationCardiovascular eventsLipoprotein cholesterolCardiovascular risk
2022
Statins and statin intensity in peripheral artery disease.
Sagris M, Katsaros I, Giannopoulos S, Rosenberg RD, Altin SE, Rallidis L, Mena-Hurtado C, Armstrong EJ, Kokkinidis DG. Statins and statin intensity in peripheral artery disease. Vasa 2022, 51: 198-211. PMID: 35673949, DOI: 10.1024/0301-1526/a001012.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPeripheral artery diseaseLow-intensity statinsLoss of patencyStatin useStatin doseIntensity statinsArtery diseaseFirst-line lipid-lowering therapyAdverse cardiovascular eventsAmputation-free survivalHigher statin doseLipid-lowering therapyMyocardial infarction rateRisk of amputationImpact of statinsStatin intensityCardiovascular eventsPAD patientsCardiovascular deathCardiovascular mortalityCause mortalityInfarction rateIschemia patientsStatin treatment
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