2021
RNA chaperone activates Salmonella virulence program during infection
Choi J, Salvail H, Groisman EA. RNA chaperone activates Salmonella virulence program during infection. Nucleic Acids Research 2021, 49: 11614-11628. PMID: 34751407, PMCID: PMC8599858, DOI: 10.1093/nar/gkab992.Peer-Reviewed Original ResearchConceptsPhoP activationVirulence regulator PhoPWild-type virulenceBacterium Salmonella enterica serovar TyphimuriumWild-type S. typhimuriumSalmonella enterica serovar TyphimuriumRNA chaperonesEnterica serovar TyphimuriumRegulator PhoPRedundant proteinsMutant behavesVirulence programVirulence roleS. typhimuriumInside macrophagesSecondary structureSerovar TyphimuriumCritical functionsVirulence genesChaperonesPhoPMutantsRibosomesOrganismsCSPC
2017
Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation
May J, Rasmussen D, Davie T, Vaneerd C, Groisman E, Bhattacharyya B. Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.761.11.Peer-Reviewed Original ResearchPeriplasmic lipoproteinMagnesium limitationAtomic-resolution structural dataFamily of proteinsFundamental biochemical processesBeta-sheet secondary structureAdaptation of SalmonellaGenetic screenCircular dichroism spectroscopyBacterial adaptationLocalization sequenceSalmonella proteinsBiochemical approachesIon homeostasisBacterial virulenceProtein monomersBiochemical characterizationCertain pathogenic bacteriaMolecular mechanismsMonomeric molecular weightUnknown functionPhysiological functionsLiving cellsSecondary structureDichroism spectroscopy
2011
Genome-wide detection of novel regulatory RNAs in E. coli
Raghavan R, Groisman EA, Ochman H. Genome-wide detection of novel regulatory RNAs in E. coli. Genome Research 2011, 21: 1487-1497. PMID: 21665928, PMCID: PMC3166833, DOI: 10.1101/gr.119370.110.Peer-Reviewed Original ResearchConceptsSmall RNAsLeader sequenceIntergenic regionRegulatory elementsRegulatory RNAsNew small RNAsStable RNA secondary structureNovel regulatory RNAsProtein-coding transcriptsNovel small RNAsGenome-wide detectionNoncoding regulatory RNAsE. coliRNA secondary structureProtein HfqPhylogenetic conservationBacterial genomesEvolutionary analysisPresence of hundredsSequencing approachGene expressionCompensatory mutationsEnteric speciesSecondary structureEscherichia coli