2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original Research
2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas
2021
Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles
Rothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.Chapters
2014
Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy
Hyder F, Fulbright R, Shulman R, Rothman D. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 368-368. PMCID: PMC3915214, DOI: 10.1038/jcbfm.2013.205.Peer-Reviewed Original Research
2013
CMR02 Mapping by Calibrated fMRI
Hyder F, Shu C, Herman P, Sanganahalli B, Coman D, Rothman D. CMR02 Mapping by Calibrated fMRI. Series In Medical Physics And Biomedical Engineering 2013, 20130539: 85-109. DOI: 10.1201/b14814-5.Peer-Reviewed Original Research
2008
Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small Animals
Xu F, Shafer J, Liu N, Rothman D, Hyder F, Shepherd G. Coding of Peripheral Olfactory Information in the Olfactory Bulb of Small Animals. 2008, 279-283. DOI: 10.1007/978-1-4020-8387-7_49.Peer-Reviewed Original Research
2005
The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRI
Schafer J, Kida I, Xu F, Rothman D, Hyder F. The intra and inter-subject reproducibility of rodent olfactory bulb activity maps measured with fMRI. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s336-s336. DOI: 10.1038/sj.jcbfm.9591524.0336.Peer-Reviewed Original ResearchHigh resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats
Blumenfeld H, Nersesyan H, Khubchandani M, Schridde U, Berman R, Rothman D, Hyder F. High resolution measurements of neuronal activity, cerebral blood flow, and fMRI during spike-wave seizures in WAG/Rij rats. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s409-s409. DOI: 10.1038/sj.jcbfm.9591524.0409.Peer-Reviewed Original Research
2002
Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements
Hyder F, Kida I, Smith A, Blumenfeld H, Shulman R, Rothman D. Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Congress Series 2002, 1235: 57-71. DOI: 10.1016/s0531-5131(02)00173-5.Peer-Reviewed Original ResearchMagnetic resonance imagingRat brainNeuronal activityFunctional MRIBOLD fMRI signalCerebral cortexNeuronal glucose oxidationRat cerebral cortexFunctional magnetic resonance imagingFMRI signalsBOLD functional MRIQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesMulti-modal magnetic resonance imagingQuantitative functional MRIGlutamatergic neuronsOxygen deliveryPhysiologic basisResonance imagingPhysiologic componentsCMRO2BrainBlood circulationOxygenation level
2001
Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imaging
Hyder F, Kida I, Kennan R, Rothman D. Cerebral blood volume changes with functional and CO2 challenges: quantitative BOLD imaging. NeuroImage 2001, 13: 983. DOI: 10.1016/s1053-8119(01)92321-3.Peer-Reviewed Original Research
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