2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original Research
2024
Resting-state functional MRI of the nose as a novel investigational window into the nervous system
Ponticorvo S, Paasonen J, Stenroos P, Salo R, Tanila H, Filip P, Rothman D, Eberly L, Garwood M, Metzger G, Gröhn O, Michaeli S, Mangia S. Resting-state functional MRI of the nose as a novel investigational window into the nervous system. Scientific Reports 2024, 14: 26352. PMID: 39487180, PMCID: PMC11530622, DOI: 10.1038/s41598-024-77615-z.Peer-Reviewed Original ResearchConceptsFunctional MRICentral nervous system integrityAutonomic nervous system innervationNervous system innervationAir-tissue interfaceNervous system integrityNervous system activityAutonomic nervous system activityAwake miceResting-state functional MRIAir intakeAbundant vasculatureCSF spacesNervous systemHeart rateSystem activityMRIBrain vesselsClearance sitesResting-stateSystem integrationHealthy participantsNoseSignal lossBreathing rateIn vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply