Featured Publications
Emerging roles of PLCÎł1 in endothelial biology
Chen D, Simons M. Emerging roles of PLCÎł1 in endothelial biology. Science Signaling 2021, 14 PMID: 34344833, PMCID: PMC8507396, DOI: 10.1126/scisignal.abc6612.Peer-Reviewed Original ResearchConceptsUnique protein structurePhospholipase C-Îł1Receptor tyrosine kinasesRole of PLCÎł1Major physiological roleMolecular functionsDistinct vascular phenotypePLC familyC-Îł1Signal transducerProtein structureDirect effectorTyrosine kinaseMembrane lipidsSecond messengerFunction mutationsPhysiological rolePLCÎł1Endothelial biologyEndothelial cancerCritical roleVascular phenotypeEndothelial cellsKinaseFuture investigations
2023
Endothelial VEGFR2-PLCÎł signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src
Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love D, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src. Journal Of Clinical Investigation 2023, 133: e161366. PMID: 37651195, PMCID: PMC10575733, DOI: 10.1172/jci161366.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRenal cell carcinomaAnti-tumor immunityVascular leakageT cellsEndothelial barrierClear cell renal cell carcinomaCell renal cell carcinomaRegulatory T cellsHelper T cellsNitric oxide synthaseImmune cell activationAntitumor immunityImmunosuppressive cytokinesPoor prognosisCell carcinomaPLCγ pathwayOxide synthaseVascular permeabilityB cellsActivation of PLCγCell activationTumor vesselsDecreased expressionCancer forms
2018
Reprogramming the Endocardium
Chen D, Simons M. Reprogramming the Endocardium. Circulation Research 2018, 122: 913-915. PMID: 29599272, PMCID: PMC5880288, DOI: 10.1161/circresaha.118.312810.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply