2025
39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration
Datta D, Perone I, Wijegunawardana D, Liang F, Morozov Y, Arellano J, Duque A, Xie Z, van Dyck C, Joyce M, Arnsten A. 39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. Journal Of Clinical And Translational Science 2025, 9: 13-13. PMCID: PMC12038495, DOI: 10.1017/cts.2024.726.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexEntorhinal cortexStatistically significant age-related increaseTau pathologySignificant age-related increaseAlzheimer's diseaseAge-related increaseBrain circuitsRhesus macaquesAged rhesus macaquesAging brainAged macaquesCortical pathologyCortexAge spanDendritic spinesEarly-stage neurodegenerationBrainTau speciesSubcellular localizationInhibitory synapsesPhosphorylated proteinsDysmorphic mitochondriaPostsynaptic compartmentsContrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices
Joyce M, Datta D, Arellano J, Duque A, Morozov Y, Morrison J, Arnsten A. Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices. Frontiers In Neuroanatomy 2025, 19: 1553056. PMID: 40255911, PMCID: PMC12006084, DOI: 10.3389/fnana.2025.1553056.Peer-Reviewed Original ResearchSubgenual cingulate cortexDorsolateral prefrontal cortexPrefrontal cortexPutative pyramidal neuronsN-methyl-D-aspartate receptorsN-methyl-D-aspartateSporadic Alzheimer's diseaseSubgenual cingulateCingulate cortexWorking memoryMacaque dlPFCDlPFCNMDAR antagonistsGluN2B subunitVulnerable to alterationsCortexSynaptic expressionPyramidal neuronsSynaptic functionAlzheimer's diseaseNeurodegenerative processesExtrasynaptic sitesTau pathologySchizophreniaCingulateThe etiology and prevention of early‐stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques
Datta D, Arnsten A. The etiology and prevention of early‐stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques. Alzheimer's & Dementia 2025, 21: e14477. PMID: 39776253, PMCID: PMC11848412, DOI: 10.1002/alz.14477.Peer-Reviewed Original ResearchConceptsAged macaquesAged rhesus macaquesP-tauTau hyperphosphorylationCortical circuitsAmyloid-beta generationSoluble phosphorylated tauCognitive deficitsAged monkeysSoluble hyperphosphorylated tauSporadic Alzheimer's diseaseAssociation cortexEarly-stage pathologyRhesus macaquesIncreased ABCalcium dysregulationCalcium regulationToxic to neuronsHyperphosphorylated tauAmyloid-betaCortexInflammatory signalingP-tau217 levelsTau pathologyPhosphorylated tau
2024
Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration
Datta D. Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration. Alzheimer's & Dementia 2024, 20: e089418. PMCID: PMC11709465, DOI: 10.1002/alz.089418.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexEntorhinal cortexStatistically significant age-related increaseAged macaquesTau pathologySignificant age-related increaseAlzheimer's diseaseAge-related increaseCognitive deficitsBrain circuitsBrain expressionAging brainBrain pathologyCortical pathologyCortexEfficacy of novel treatmentsDlPFCAge spanDendritic spinesEarly-stage neurodegenerationInhibitory synapsesLayer IIBrainRhesus macaquesThe meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition
Magrou L, Joyce M, Froudist-Walsh S, Datta D, Wang X, Martinez-Trujillo J, Arnsten A. The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition. Cerebral Cortex 2024, 34: bhae174. PMID: 38771244, PMCID: PMC11107384, DOI: 10.1093/cercor/bhae174.Peer-Reviewed Original ResearchConceptsInter-areal connectionsVisual cortexPrimary visual cortexHigher cortical areasMacaque cortexPrimate specializationHigher cognitionPrimate cortexV1Working memory storageDendritic spine densityTop-down regulationPrefrontal cortexConnection structureSpine densityFunctional segregationCortical areasFrontal areasCortexConnectomeNetwork organizationMemory storageMultimodal associationβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cells
2023
557. Nanoscale Imaging of pT217-Tau in Aged Rhesus Macaque: Trans-Synaptic Propagation and Seeding of Tau Pathology in Entorhinal Cortex
Datta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. 557. Nanoscale Imaging of pT217-Tau in Aged Rhesus Macaque: Trans-Synaptic Propagation and Seeding of Tau Pathology in Entorhinal Cortex. Biological Psychiatry 2023, 93: s319. DOI: 10.1016/j.biopsych.2023.02.797.Peer-Reviewed Original Research
2022
P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal Cortex
Datta D, Mentone S, Morozov Y, Arnsten A. P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal Cortex. Biological Psychiatry 2022, 91: s281-s282. DOI: 10.1016/j.biopsych.2022.02.713.Peer-Reviewed Original Research
2021
Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective
Arnsten AFT, Datta D, Preuss TM. Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective. American Journal Of Primatology 2021, 83: e23254. PMID: 33960505, PMCID: PMC8550995, DOI: 10.1002/ajp.23254.Peer-Reviewed Original ResearchConceptsTau pathologyAssociation cortexAlzheimer's diseaseTau phosphorylationNMDAR-NR2BRhesus monkeysCognitive deficitsMonkey dorsolateral prefrontal cortexAlzheimer-like neuropathologyInternal calcium releaseGenetic mouse modelsDorsolateral prefrontal cortexSynaptic lossNeurofibrillary tanglesAmyloid plaquesMouse modelEarly molecular eventsSporadic formsAutosomal dominant formCalcium releasePerfusion fixationCortexPrefrontal cortexNonhuman primatesPathology
2020
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Arnsten AFT, Datta D, Del Tredici K, Braak H. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & Dementia 2020, 17: 115-124. PMID: 33075193, PMCID: PMC7983919, DOI: 10.1002/alz.12192.Peer-Reviewed Original ResearchConceptsAbnormal tau phosphorylationTau pathologyProjection neuronsTau phosphorylationAssociation cortexAlzheimer's diseaseBrain tau pathologySporadic Alzheimer's diseaseSusceptible microenvironmentCalcium dysregulationVulnerable neuronsAβ plaquesAβ productionSporadic formsSAD pathologyRhesus monkeysAbnormal phosphorylationPathological eventsDiseaseAβ oligomersPathologyNeuronsVicious cycleCortexTau
2019
P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD
Datta D, Morozov Y, Arellano J, van Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD. Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.Peer-Reviewed Original Research
2018
P3‐088: THE AGING RHESUS MONKEY IS AN APPROPRIATE NEW ANIMAL MODEL FOR STUDYING THE ETIOLOGY AND TREATMENT OF TAU PATHOLOGY IN ASSOCIATION CORTEX
Arnsten A, Carlyle B, Leslie S, Preuss T, Crimins J, Datta D, Anita H, van Dyck C, Rosene D, Nairn A, Paspalas C. P3‐088: THE AGING RHESUS MONKEY IS AN APPROPRIATE NEW ANIMAL MODEL FOR STUDYING THE ETIOLOGY AND TREATMENT OF TAU PATHOLOGY IN ASSOCIATION CORTEX. Alzheimer's & Dementia 2018, 14: p1099-p1099. DOI: 10.1016/j.jalz.2018.06.1444.Peer-Reviewed Original Research
2017
[O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASE
Datta D, Morozov Y, Paspalas A. [O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASE. Alzheimer's & Dementia 2017, 13: p553-p553. DOI: 10.1016/j.jalz.2017.07.151.Peer-Reviewed Original Research
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