2002
Radiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrow
Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrow. Experimental Hematology 2002, 30: 1333-1338. PMID: 12423687, DOI: 10.1016/s0301-472x(02)00931-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBone Marrow TransplantationCell DifferentiationCell LineageEpithelial CellsFemaleGraft SurvivalIn Situ Hybridization, FluorescenceLungMaleMiceModels, AnimalPulmonary AlveoliPulmonary Surfactant-Associated Protein BRadiation ChimeraRadiation PneumonitisRNA, MessengerStem Cell TransplantationStem CellsY ChromosomeConceptsBone marrow transplantType II pneumocytesBone marrow cellsFemale miceLethal irradiationAge-matched male donorsWhole bone marrow transplantsMarrow cellsDay 5 posttransplantAlveolar lining cellsFluorescence-activated cell sorterSevere injury modelType I cellsAlveolar breakdownEntire alveoliRadiation pneumonitisB messenger RNAHistologic evidenceMarrow transplantAcute injuryMonth 2Injury modelLung tissueLining cellsBone marrow
2001
Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34+ cells
Burgess J, Mills B, Griffith M, Mansour V, Weaver CH, Schwartzberg LS, Snyder EL, Krause DS, Yanovich S, Prilutskaya M, Umiel T, Moss TJ. Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34+ cells. Cytotherapy 2001, 3: 285-294. PMID: 12171717, DOI: 10.1080/146532401317070925.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalAntigens, CD34BiomarkersBreast NeoplasmsCell CountFemaleHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunohistochemistryImmunomagnetic SeparationLymphocytesMiddle AgedNeoplastic Cells, CirculatingPredictive Value of TestsReproducibility of ResultsConceptsCD34(-) cell fractionsBrCa cellsPBSC harvestsBRCA patientsCell fractionApheresis harvestsAutologous PBSC supportBreast cancer patientsMedian log depletionHighdose chemotherapyPBSC contaminationPBSC supportTumor contaminationCancer patientsICC detectionCell selectionLog depletionPatientsStandard immunocytochemistryImmunomagnetic enrichmentTumor cellsApheresis collectionsTumor depletionCell numberPrevalence
2000
Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial
Yanovich S, Mitsky P, Cornetta K, Maziarz R, Rosenfeld C, Krause D, Lotz J, Bitran J, Williams S, Preti R, Somlo G, Burtness B, Mills B. Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial. Bone Marrow Transplantation 2000, 25: 1165-1174. PMID: 10849529, DOI: 10.1038/sj.bmt.1702415.Peer-Reviewed Original ResearchConceptsHigh-risk breast cancer patientsBreast cancer patientsMedian timeCancer patientsIsolated CD34Clinical trialsCell selection systemHematopoietic reconstitutionHigh-risk breast cancerCapacity of CD34Transplantation of CD34Absolute neutrophil countDuration of hospitalizationHigh-dose chemotherapyMulticenter clinical trialBone Marrow Transplantation (2000) 25Incidence of infectionPeripheral blood cellsInter-group differencesProgenitor cell graftsPlatelet engraftmentNeutrophil countCell transplantPlatelet transfusionsPlatelet count
1996
CD34: Structure, Biology, and Clinical Utility
Krause D, Fackler M, Civin C, May W. CD34: Structure, Biology, and Clinical Utility. Blood 1996, 87: 1-13. PMID: 8547630, DOI: 10.1182/blood.v87.1.1.1.Peer-Reviewed Original ResearchAcute DiseaseAmino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, CD34Antigens, NeoplasmBiomarkersCell AdhesionEndothelium, VascularFibroblastsGene Expression RegulationGenesHematopoietic Stem CellsHumansLeukemia, MyeloidMiceMolecular Sequence DataOrgan SpecificityProtein ConformationRNA Splicing