3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS
Chen M, Mayday M, Espinosa A, Zhang M, Zhang P, Wang L, Rahman N, Krause D. 3046 – FUNCTIONAL CHARACTERIZATION OF RBM15-MKL1 FUSION PROTEIN IN AMKL TUMORIGENESIS. Experimental Hematology 2024, 137: 104368. DOI: 10.1016/j.exphem.2024.104368.Peer-Reviewed Original ResearchChromatin associationRBM15-MKL1TPA-induced megakaryocytic differentiationHuman erythroleukemiaAcute megakaryoblastic leukemiaAssociated with chromatinTranscriptional regulatory functionRNA-binding proteinsTranscriptional co-activatorM6A RNA modificationShRNA-mediated knock-downHuman erythroleukemia cellsChromatin regionsRNA modificationsTranscriptional regulationMolecular functionsAberrant transcriptsFusion proteinGO analysisMKL1Knock-downBinding proteinRegulatory functionsFusion geneDifferentiation block