Featured Publications
A clonal expression biomarker associates with lung cancer mortality
Biswas D, Birkbak N, Rosenthal R, Hiley C, Lim E, Papp K, Boeing S, Krzystanek M, Djureinovic D, La Fleur L, Greco M, Döme B, Fillinger J, Brunnström H, Wu Y, Moore D, Skrzypski M, Abbosh C, Litchfield K, Al Bakir M, Watkins T, Veeriah S, Wilson G, Jamal-Hanjani M, Moldvay J, Botling J, Chinnaiyan A, Micke P, Hackshaw A, Bartek J, Csabai I, Szallasi Z, Herrero J, McGranahan N, Swanton C. A clonal expression biomarker associates with lung cancer mortality. Nature Medicine 2019, 25: 1540-1548. PMID: 31591602, PMCID: PMC6984959, DOI: 10.1038/s41591-019-0595-z.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerClinicopathological risk factorsCell lung cancerLung cancer mortalityPrognostic gene expression signaturesCancer cell proliferationGene expression signaturesCancer mortalityLung cancerRisk factorsExpression-based biomarkersCopy number gainsDisease subtypesClinical descriptorsTranscriptomic biomarkersIndividual tumorsCancer typesDiagnostic precisionMolecular biomarkersExpression signaturesCell proliferationDNA copy number gainsBiomarkersPatientsIntratumor heterogeneityProspective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
Biswas D, Liu Y, Herrero J, Wu Y, Moore D, Karasaki T, Grigoriadis K, Lu W, Veeriah S, Naceur-Lombardelli C, Magno N, Ward S, Frankell A, Hill M, Colliver E, de Carné Trécesson S, East P, Malhi A, Snell D, O’Neill O, Leonce D, Mattsson J, Lindberg A, Micke P, Moldvay J, Megyesfalvi Z, Dome B, Fillinger J, Nicod J, Downward J, Szallasi Z, Hackshaw A, Jamal-Hanjani M, Kanu N, Birkbak N, Swanton C. Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer 2025, 6: 86-101. PMID: 39789179, PMCID: PMC11779643, DOI: 10.1038/s43018-024-00883-1.Peer-Reviewed Original ResearchConceptsLung adenocarcinomaStage I diseaseClinicopathological risk factorsSurvival of patientsResponse to treatmentRNA sequencing dataI diseaseSequence dataMetastatic clonesNeedle biopsyIndividual tumorsLung expressionTranscription signalsPrognostic informationWhole exomeExpressed genesChemotherapy sensitivityProspective validationSurvival associationsTranscriptomic heterogeneityHuman tumorsEvolutionary measuresChromosomal instabilityRisk factorsNatural history
2020
Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
Balestrini S, Koepp M, Gandhi S, Rickman H, Shin G, Houlihan C, Anders-Cannon J, Silvennoinen K, Xiao F, Zagaglia S, Hudgell K, Ziomek M, Haimes P, Sampson A, Parker A, Cross J, Pardington R, Nastouli E, Swanton C, Consortium C, Aitken J, Allen Z, Ambler R, Ambrose K, Ashton E, Avola A, Balakrishnan S, Barns-Jenkins C, Barr G, Barrell S, Basu S, Beale R, Beesley C, Bhardwaj N, Bibi S, Bineva-Todd G, Biswas D, Blackman M, Bonnet D, Bowker F, Broncel M, Brooks C, Buck M, Buckton A, Budd T, Burrell A, Busby L, Bussi C, Butterworth S, Byott M, Byrne F, Byrne R, Caidan S, Campbell J, Canton J, Cardoso A, Carter N, Carvalho L, Carzaniga R, Chandler N, Chen Q, Cherepanov P, Churchward L, Clark G, Clayton B, Gigli C, Collins Z, Cottrell S, Crawford M, Cubitt L, Cullup T, Davies H, Davis P, Davison D, Dearing V, Debaisieux S, Diaz-Romero M, Dibbs A, Diring J, Driscoll P, D'Avola A, Earl C, Edwards A, Ekin C, Evangelopoulos D, Faraway R, Fearns A, Ferron A, Fidanis E, Fitz D, Fleming J, Frampton D, Frederico B, Gaiba A, Gait A, Gamblin S, Gärtner K, Gaul L, Golding H, Goldman J, Goldstone R, Dominguez B, Gong H, Grant P, Greco M, Grobler M, Guedan A, Gutierrez M, Hackett F, Hall R, Halldorsson S, Harris S, Hashim S, Hatipoglu E, Healy L, Heaney J, Herbst S, Hewitt G, Higgins T, Hindmarsh S, Hirani R, Hope J, Horton E, Hoskins B, Howell M, Howitt L, Hoyle J, Htun M, Hubank M, Encabo H, Hughes D, Hughes J, Huseynova A, Hwang M, Instrell R, Jackson D, Jamal-Hanjani M, Jenkins L, Jiang M, Johnson M, Jones L, Kanu N, Kassiotis G, Kelly G, Kiely L, Teixeira A, Kirk S, Kjaer S, Knuepfer E, Komarov N, Kotzampaltiris P, Kousis K, Krylova T, Kucharska A, Labrum R, Lambe C, Lappin M, Lee S, Levett A, Levett L, Levi M, Liu, Loughlin S, Lu W, MacRae J, Madoo A, Marczak J, Martensson M, Martinez T, Marzook B, Matthews J, Matz J, McCall S, McCoy L, McKay F, McNamara E, Minutti C, Mistry G, Molina-Arcas M, Montaner B, Montgomery K, Moore C, Moore D, Moraiti A, Moreira-Teixeira L, Mukherjee J, Naceur-Lombardelli C, Nelson A, Nicod J, Nightingale L, Nofal S, Nurse P, Nutan S, Oedekoven C, O'Garra A, O'Leary J, Olsen J, O'Neill O, O'Reilly N, Suarez P, Osborne N, Pabari A, Pajak A, Papayannopoulos V, Paraskevopoulou S, Patel N, Patel Y, Paun O, Peat N, Castano L, Caballero A, Perez-Lloret J, Perrault M, Perrin A, Poh R, Poirier E, Polke J, Pollitt M, Prieto-Godino L, Proust A, Puvirajasinghe C, Queval C, Ramachandran V, Ramaprasad A, Ratcliffe P, Reed L, Reis e Sousa C, Richardson K, Ridewood S, Roberts F, Roberts R, Rodgers A, Clavijo P, Rosa A, Rossi A, Roustan C, Rowan A, Sahai E, Sait A, Sala K, Sanchez E, Sanderson T, Santucci P, Sardar F, Sateriale A, Saunders J, Sawyer C, Schlott A, Schweighoffer E, Segura-Bayona S, Punatar R, Shahmanesh M, Shaw J, Dos Santos M, Silvestre M, Singer M, Snell D, Song O, Spyer M, Steel L, Strange A, Sullivan A, Tan M, Tautz-Davis Z, Taylor E, Taylor G, Taylor H, Taylor-Beadling A, Subtil F, Torras B, Toolan-Kerr P, Torelli F, Toteva T, Treeck M, Trojer H, Tsai M, Turner J, Turner M, Ule J, Ulferts R, Vanloo S, Veeriah S, Venkatesan S, Vousden K, Wack A, Walder C, Walker P, Wang Y, Ward S, Wenman C, Williams L, Williams M, Wong W, Wright J, Wu M, Wynne L, Xiang Z, Yap M, Zagalak J, Zecchin D, Zillwood R, Sander J, Sisodiya S, Consortium: C, Carthiyaniamma S, DeTisi J, Dick J, Hill A, Kipper K, Kullar B, Norris S, Rugg-Gunn F, Salvatierra R, Shaya G, Sloan A, Singh P, Varley J, Whatley B. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy. Epilepsy & Behavior 2020, 115: 107602. PMID: 33279440, PMCID: PMC7643621, DOI: 10.1016/j.yebeh.2020.107602.Peer-Reviewed Original ResearchConceptsLong-term care facilitiesCare facilitiesChalfont Centre for EpilepsyResident-to-residentCo-morbiditiesCOVID-19 residentsPreventive measuresMeasured infection ratesCaregiver's levelOne-off testMultiple co-morbiditiesVulnerable peopleCaregiversEpilepsy-related factorsHospital admissionCohort studySymptomatic casesInfection preventionAsymptomatic peopleCOVID-19Clinical outcomes of COVID-19Rates of morbidityAsymptomatic individualsYoung adultsOutcomes of COVID-19
2019
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
Chemi F, Rothwell D, McGranahan N, Gulati S, Abbosh C, Pearce S, Zhou C, Wilson G, Jamal-Hanjani M, Birkbak N, Pierce J, Kim C, Ferdous S, Burt D, Slane-Tan D, Gomes F, Moore D, Shah R, Al Bakir M, Hiley C, Veeriah S, Summers Y, Crosbie P, Ward S, Mesquita B, Dynowski M, Biswas D, Tugwood J, Blackhall F, Miller C, Hackshaw A, Brady G, Swanton C, Dive C. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine 2019, 25: 1534-1539. PMID: 31591595, PMCID: PMC6986897, DOI: 10.1038/s41591-019-0593-1.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerEarly-stage non-small-cell lung cancerDisease relapseGenomic profilingHigh risk of recurrenceDetection of circulating tumor cellsRisk of recurrenceTumor cell disseminationTime of surgeryPredictors of relapsePotential clinical utilityCurative intentPrimary tumorSurgical resectionTumor resectionTumor stagePredicting relapseCell disseminationTumor cellsLung cancerMutational overlapRelapseMultivariate analysisSurgeryHigh risk
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply