Featured Publications
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
Biswas D, Liu Y, Herrero J, Wu Y, Moore D, Karasaki T, Grigoriadis K, Lu W, Veeriah S, Naceur-Lombardelli C, Magno N, Ward S, Frankell A, Hill M, Colliver E, de Carné Trécesson S, East P, Malhi A, Snell D, O’Neill O, Leonce D, Mattsson J, Lindberg A, Micke P, Moldvay J, Megyesfalvi Z, Dome B, Fillinger J, Nicod J, Downward J, Szallasi Z, Hackshaw A, Jamal-Hanjani M, Kanu N, Birkbak N, Swanton C. Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer 2025, 6: 86-101. PMID: 39789179, PMCID: PMC11779643, DOI: 10.1038/s43018-024-00883-1.Peer-Reviewed Original ResearchConceptsLung adenocarcinomaStage I diseaseClinicopathological risk factorsSurvival of patientsResponse to treatmentRNA sequencing dataI diseaseSequence dataMetastatic clonesNeedle biopsyIndividual tumorsLung expressionTranscription signalsPrognostic informationWhole exomeExpressed genesChemotherapy sensitivityProspective validationSurvival associationsTranscriptomic heterogeneityHuman tumorsEvolutionary measuresChromosomal instabilityRisk factorsNatural history
2022
Abstract A040: Intra-epithelia cell dynamics shape evolutionary dynamics and selection of therapy resistant clones in lung cancer
Fu X, Bhargava A, Bailey S, Biswas D, Ruiz C, Kumar S, French P, McGranahan N, Swanton C, Bates P, Sahai E. Abstract A040: Intra-epithelia cell dynamics shape evolutionary dynamics and selection of therapy resistant clones in lung cancer. Cancer Research 2022, 82: a040-a040. DOI: 10.1158/1538-7445.evodyn22-a040.Peer-Reviewed Original ResearchEvolutionary dynamicsResistant clonesEnhanced cell motilityCapability of cancer cellsCell-cell cohesionRNA sequencing dataCell dynamicsExpansion of clonesModel of cell proliferationLung cancer cell linesVariant allele frequencySequence dataNeutral evolutionCell motilityGenomic complexityCancer cell linesCell line modelsAllele frequenciesSelection pressureRandom motilityGrowth arrestMutational processesClonesCell migrationIntra-tumor heterogeneity
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply