2025
Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis
Yang X, Zhang X, Tian Y, Yang J, Jia Y, Xie Y, Cheng L, Chen S, Wu L, Qin Y, Zhao Z, Zhao D, Wei Y. Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis. Circulation Research 2025, 136: 985-1009. PMID: 40160097, DOI: 10.1161/circresaha.124.326111.Peer-Reviewed Original ResearchConceptsAlternative polyadenylationAssociated with atherosclerosis progressionUntranslated regionRNA sequencingExpression of chemokinesRegulation of cell fateAlternative polyadenylation patternsEfficient mitochondrial translationMetabolic labeling assaysSingle-cell RNA sequencingIntegrated stress responseMyeloid deletionLow-density lipoproteinMonocytes to macrophagesImpairment of protein synthesisPhagocytic impairmentMetabolomic profilesMacrophage maturationPrecursor nicotinamide mononucleotideCirculating monocytesIntegrated stress response inhibitorLesional cellsHistopathological analysisProatherosclerotic effectsNicotinamide mononucleotide treatment
2024
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2016
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E. Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLOS Genetics 2016, 12: e1006151. PMID: 27414999, PMCID: PMC4944976, DOI: 10.1371/journal.pgen.1006151.Peer-Reviewed Original ResearchConceptsMerkel cell specificationCell specificationPrimary hair folliclesLoss of PolycombImportance of ShhCell differentiation programHair follicle functionSonic hedgehog (Shh) signalingPRC2 targetsSpecialized keratinocytesEpidermal progenitorsDevelopmental programHair folliclesEpigenetic processesDifferentiation programHedgehog signalingShh ligandMature Merkel cellsShh signalingSkin developmentMurine dorsal skinEpidermal cellsMerkel cellsPRC2 lossCell formation
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