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David Seifer

Professor of Obstetrics, Gynecology & Reproductive Sciences

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David Seifer

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David Seifer
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I am very pleased to be part of the Yale Fertility Center. I look forward to providing the best clinical experience for each of my patients while utilizing one of the most advanced reproductive facilities in the U.S. My approach is to provide the most compassionate and contemporary infertility services available to meet the individual needs and personal values of my patients. Areas of special clinical interest include optimizing age-related infertility, pre-implantation genetic diagnosis, male factor infertility, recurrent pregnancy loss, polycystic ovarian syndrome and fertility preservation.

My research includes the mechanisms of reproductive aging. This work has led to a simple blood test, antimullerian hormone (AMH), used worldwide today that helps determine the health of a woman’s ovaries, a rough estimate of her egg count and real time assessment of her biological clock. To learn more read:

I am currently co-editing a book entitled Reproductive Aging to be published by Cambridge University Press scheduled for publication in 2020.

Recent publications:

Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of ART outcomes of cycles with ultra-low serum antimüllerian hormone (AMH): a multivariate analysis of over 5000 autologous cycles from the SART CORS database for 2012-2013. Fertil Steril 105:385-93, 2016.

Seifer DB, Tal R (ed): Anti-Mullerian Hormone: Biology, Role in Ovarian Function and Clinical Significance. New York, Nova Science, 2016.

Kushnir VA, Seifer DB, Barad DH, Sen A, Gleicher N. Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine. J Assist Reprod Genet. 2017 Sep;34(9):1105-1113. 

Tal R, Seifer DB, Wantman E, Baker VL, Tal O. AMH as predictor of live birth following assisted reproductive technology: analysis of 85,062 fresh and thawed cycles from the SART COR database for 2012-2013. Fertil Steril. 109:258-265, 2018.

 I also have had a research focus in population-based health outcomes research to gain better understanding of the trends of reproductive aging, health care disparities in IVF, vitamin D deficiency in reproductive health and a global improvement in the clinical practice of reproductive medicine. This has been achieved through collaborative studies and analysis of large clinical data sets from well characterized populations through the Assisted Reproductive Technologies Clinical Outcomes Reporting System (SART CORS), the Women's Interagency HIV Study (WIHS), the National Assisted Reproductive Technology Surveillance System (NASS) registries and the Reproductive Medicine Network (RMN).

Recent publications:

Zagadailov P, Hsu A, Stern JE, Seifer DB. Temporal differences in utilization of intracytoplasmic sperm injection among U.S. regions. Obstet Gynecol. 2018 Aug;132(2):310-320. (NASS database)

Butts SF*, Seifer DB*, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Kraetz SA, Santoro N, Zhang H, Diamond MP, Legro RS. Vitamin D deficiency is associated with poor ovarian stimulation outcome in PCOS but not unexplained infertility. J Clin Endocrinol Metab, Metab, 2019 Feb 1;104(2):369-378. (RMN database) *co-first authors

Luke B, Brown MB, Wantman E, Doody K, Seifer DB, Spector LG. Risk of severe maternal morbidity maternal age, fertility status, plurality and mode of delivery: A US study in eight states. Am J Obstet Gynecol. 2018 Oct 12. pii: S0002-9378(18)30894-9. doi: 10.1016/j.ajog.2018.10.012.   (SART CORS database linked with birth certificate database in 8 Departments of Health)

Luke B, Brown MB, Wantman E, Seifer DB, Sparks AT, Lin PC, Doody KJ, Van Voorhis BJ, Spector LG. Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality.J Assist Reprod Genet. 2019 Jan;36(1):121-138. doi: 10.1007/s10815-018-1333-z. (SART CORS database linked with birth and death certificate database in 14 Departments of Health)

I am the immediate past-president of the Society for Assisted Reproductive Technology (SART), the primary, national organization that sets clinical and laboratory guidelines as well as the standards for safety and quality metrics for the practice of IVF in the US. As such, I am interested in using patient-physician advocacy to move toward expanding insurance coverage for infertility treatment for those who are without such benefits as well as moving toward strategies of closing the gap in disparities of access and outcomes in the utilization of IVF. I am also actively encouraging and mentoring young Yale faculty to bring their energy and insight to a national level within SART.

Recent publication:

Seifer DB, Wantman E, Sparks AE, Luke B, Doody KJ, Toner JP, van Voorhis BJ, Lin PC, Reindollar RH. National survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies. Fertil Steril. 2018 Nov;110(6):1081-1088.

As Co-Editor-in- Chief of Reproductive Biology and Endocrinology (RB&E) I am actively involved in encouraging the publication of quality and novel research in the reproductive sciences.

Complete list of Published Work:

Honors & Recognition

AwardAwarding OrganizationDate
ASRM Star AwardAmerican Society of Reproductive Medicine2016, 2017, 2018, 2019
America’s Top Doctors Castle Connolly Medical Guide for 12 yearsCastle Connolly2014
Thomas Alva Edison Patent AwardResearch and Development Council of New Jersey2011
Inventor of the Year AwardNew Jersey Inventors Hall of Fame2011
Life Teacher AwardMaimonides Medical Center2007

Professional Service

Society for Assisted Reproductive Technology (SART)President 2017-2018 Immediate Past President 2018-20192017 - Present
Reproductive Biology and EndocrinologyCo-Editor-in-Chief2016 - Present
NICHD – NIH Reproduction, Andrology, Gynecology Study Section2004 - 2008
FDA Advisory Committee Obstetrics and Gynecology Devices Panel2001 - 2005

Departments & Organizations