2019
Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment
De Coen R, Nuhn L, Perera C, Arista-Romero M, Risseeuw M, Freyn A, Nachbagauer R, Albertazzi L, Van Calenbergh S, Spiegel D, Peterson B, De Geest B. Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment. Biomacromolecules 2019, 21: 793-802. PMID: 31829561, DOI: 10.1021/acs.biomac.9b01483.Peer-Reviewed Original ResearchConceptsImmune systemAntibody-mediated effector functionsTarget cell surfaceHuman serumEffector functionsCell surface membraneCell surface receptorsTarget cellsMonoclonal antibodiesAntibodiesAntibody recruitmentImmunotherapeuticsSmall molecule compoundsSerumCell surfaceLipophilic end groupsEnd groups
2010
Grand Challenge Commentary: Synthetic immunology to engineer human immunity
Spiegel DA. Grand Challenge Commentary: Synthetic immunology to engineer human immunity. Nature Chemical Biology 2010, 6: 871-872. PMID: 21079593, DOI: 10.1038/nchembio.477.Peer-Reviewed Original ResearchA Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules
Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. Journal Of The American Chemical Society 2010, 132: 12711-12716. PMID: 20726553, PMCID: PMC2965167, DOI: 10.1021/ja104591m.Peer-Reviewed Original Research
2009
Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer
Murelli RP, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer. Journal Of The American Chemical Society 2009, 131: 17090-17092. PMID: 19888723, PMCID: PMC2794306, DOI: 10.1021/ja906844e.Peer-Reviewed Original ResearchConceptsSmall moleculesFundamental chemical principlesBifunctional small moleculesProstate-specific membrane antigenProstate cancer cellsProstate cancerChemical principlesBiological evaluationCrystallographic dataMoleculesAmerican male populationTernary complexLNCaP human prostate cancer cellsCancer cellsHuman effector cellsHuman prostate cancer cellsCancer-related deathAntibody-dependent killingClasses of antibodiesHigh therapeutic potentialNovel classAntibody-recruiting moleculesHuman immune systemAnti-DNP antibodiesEffector cellsAn Antibody-Recruiting Small Molecule That Targets HIV gp120
Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An Antibody-Recruiting Small Molecule That Targets HIV gp120. Journal Of The American Chemical Society 2009, 131: 16392-16394. PMID: 19839582, PMCID: PMC2783809, DOI: 10.1021/ja9057647.Peer-Reviewed Original ResearchConceptsVirus entryComplement-mediated destructionNew treatment strategiesAntibody-recruiting small moleculeAnti-HIV activityHIV/AIDSViral glycoprotein gp120Env-expressing cellsHuman immune systemHuman T cellsSurface viral glycoproteinsHIV treatmentTreatment strategiesHIV survivalT cellsNovel small moleculesHIV gp120Glycoprotein gp120Immune systemGp120Virus replicationAntibodiesGlobal pandemicViral glycoproteinsVirus particles
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