2019
Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment
De Coen R, Nuhn L, Perera C, Arista-Romero M, Risseeuw M, Freyn A, Nachbagauer R, Albertazzi L, Van Calenbergh S, Spiegel D, Peterson B, De Geest B. Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment. Biomacromolecules 2019, 21: 793-802. PMID: 31829561, DOI: 10.1021/acs.biomac.9b01483.Peer-Reviewed Original ResearchConceptsImmune systemAntibody-mediated effector functionsTarget cell surfaceHuman serumEffector functionsCell surface membraneCell surface receptorsTarget cellsMonoclonal antibodiesAntibodiesAntibody recruitmentImmunotherapeuticsSmall molecule compoundsSerumCell surfaceLipophilic end groupsEnd groups
2009
An Antibody-Recruiting Small Molecule That Targets HIV gp120
Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An Antibody-Recruiting Small Molecule That Targets HIV gp120. Journal Of The American Chemical Society 2009, 131: 16392-16394. PMID: 19839582, PMCID: PMC2783809, DOI: 10.1021/ja9057647.Peer-Reviewed Original ResearchConceptsVirus entryComplement-mediated destructionNew treatment strategiesAntibody-recruiting small moleculeAnti-HIV activityHIV/AIDSViral glycoprotein gp120Env-expressing cellsHuman immune systemHuman T cellsSurface viral glycoproteinsHIV treatmentTreatment strategiesHIV survivalT cellsNovel small moleculesHIV gp120Glycoprotein gp120Immune systemGp120Virus replicationAntibodiesGlobal pandemicViral glycoproteinsVirus particles
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