2017
High-Dose-Rate Brachytherapy As Monotherapy for Prostate Cancer: A Meta-analysis of Biochemical Control Rates and Dose Fractionation
Tien C, Chen Z, Carlson D. High-Dose-Rate Brachytherapy As Monotherapy for Prostate Cancer: A Meta-analysis of Biochemical Control Rates and Dose Fractionation. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e621. DOI: 10.1016/j.ijrobp.2017.06.2099.Peer-Reviewed Original ResearchHDR Monotherapy in Prostate Cancer: Radiobiological Considerations When Determining Biologically Effective Dose in Clinical Trials
Tien C, Carlson D, Nath R, Chen Z. HDR Monotherapy in Prostate Cancer: Radiobiological Considerations When Determining Biologically Effective Dose in Clinical Trials. Brachytherapy 2017, 16: s31. DOI: 10.1016/j.brachy.2017.04.038.Peer-Reviewed Original Research
2013
A molecular dynamics simulation of DNA damage induction by ionizing radiation
Abolfath RM, Carlson DJ, Chen ZJ, Nath R. A molecular dynamics simulation of DNA damage induction by ionizing radiation. Physics In Medicine And Biology 2013, 58: 7143-7157. PMID: 24052159, DOI: 10.1088/0031-9155/58/20/7143.Peer-Reviewed Original ResearchConceptsMolecular dynamics simulationsChemical reactionsDynamics simulationsChemical bond breaksWater moleculesMolecular dynamics softwareHydrogen abstractionHydroxyl free radicalsBond breaksChemical eventsCollection of ionsSingle protonRadicalsLow-energy electronsDNA moleculesProtonsBackbone damageFree radicalsMulti-scale simulationsIonsMoleculesReactionElectronsBroken bondsEnergy electronsTH‐F‐105‐02: Molecular Dynamics Simulation of DNA Damage Induction by Ionizing Radiation
Abolfath R, Carlson D, Chen Z, Nath R. TH‐F‐105‐02: Molecular Dynamics Simulation of DNA Damage Induction by Ionizing Radiation. Medical Physics 2013, 40: 552-552. DOI: 10.1118/1.4815815.Peer-Reviewed Original ResearchWater moleculesOH radicalsMD simulationsChemical reactionsMolecular dynamicsReaxFF molecular dynamicsHydrogen bond disruptionDynamics of OHMolecular dynamics simulationsChemical pathwaysPair of ionsResult of ionizationSuch computational approachesBond disruptionDynamics simulationsSingle protonMoleculesProtonsBeam of electronsIon distributionOHReactionElectronsIonizationComputational approach
2011
Quality Assurance Comparison of Intensity Modulated Stereotactic Radiosurgery between Different Treatment Planning Systems
Guo F, Carlson D, Chen Z, Deng J, Picone J, Nath R. Quality Assurance Comparison of Intensity Modulated Stereotactic Radiosurgery between Different Treatment Planning Systems. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s867. DOI: 10.1016/j.ijrobp.2011.06.1545.Peer-Reviewed Original Research
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxiaA Single-isocenter Multi-segment Conformal Arc Technique for Stereotactic Body Radiotherapy (SBRT)
Kim J, Decker R, Carlson D, Chang B, Nath R, Chen Z. A Single-isocenter Multi-segment Conformal Arc Technique for Stereotactic Body Radiotherapy (SBRT). International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s824. DOI: 10.1016/j.ijrobp.2010.07.1908.Peer-Reviewed Original Research
2009
A Serial-imaging Based 4D Dose Computation System for Prostate Implant Dosimetry
Chen Z, Deng J, Carlson D, Roberts K, Decker R, Rockwell S, Nath R. A Serial-imaging Based 4D Dose Computation System for Prostate Implant Dosimetry. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s349. DOI: 10.1016/j.ijrobp.2009.07.800.Peer-Reviewed Original ResearchTowards Temporal Optimization of Radiation Fractionation: The Kinetic Effects of Tumor Hypoxia, DNA Damage Repair, and Tumor Cell Repopulation
Carlson D, Keall P, Chen Z, Stewart R, Nath R, Brown J. Towards Temporal Optimization of Radiation Fractionation: The Kinetic Effects of Tumor Hypoxia, DNA Damage Repair, and Tumor Cell Repopulation. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s615-s616. DOI: 10.1016/j.ijrobp.2009.07.1407.Peer-Reviewed Original Research