2019
Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio
Yu JB, Beck TF, Anscher MS, Baschnagel AM, Brock KK, Carlson DJ, Dominello MM, Kimple RJ, Knisely JP, Mendonca MS, Mian OY, Singh AK, Moros EG, Keen JC. Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio. International Journal Of Radiation Oncology • Biology • Physics 2019, 103: 297-304. PMID: 30647006, DOI: 10.1016/j.ijrobp.2018.07.2056.Peer-Reviewed Original ResearchConceptsRadiation oncologyNew clinical trial designsAmerican SocietyHealth Research Portfolio Online Reporting Tools databaseClinical trial designNormal tissue effectsReporting Tools databaseTotal grant fundingFiscal year 2014Oncology ProgramTrial designTumor microenvironmentAcademic Radiation Oncology ProgramsGrant fundingTissue effectsRadiation deliverySuccess rateNational InstituteRadiation oncology programsActive grantsOncologyContinued advocacy
2018
Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy
Stahl JM, Qian JM, Tien CJ, Carlson DJ, Chen Z, Ratner ES, Park HS, Damast S. Extended duration of dilator use beyond 1 year may reduce vaginal stenosis after intravaginal high-dose-rate brachytherapy. Supportive Care In Cancer 2018, 27: 1425-1433. PMID: 30187220, DOI: 10.1007/s00520-018-4441-5.Peer-Reviewed Original ResearchConceptsVaginal stenosisEndometrial carcinomaMultivariable Cox proportional hazardsMultivariable Cox regression analysisVD useAcademic tertiary referral centerTertiary referral centerCox regression analysisLog-rank testCox proportional hazardsDevelopment of gradeDilator usePelvic radiotherapyReferral centerNoncompliant patientsPrimary outcomeAdjuvant brachytherapyEC patientsConclusionsThe riskRate brachytherapyProportional hazardsOptimal durationPatientsBrachytherapyStudy periodHigh Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors
Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ. High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 174-183. PMID: 30102194, PMCID: PMC6092043, DOI: 10.1016/j.ijrobp.2018.05.032.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyTumor hypoxic volumeHigh single dosesNon-small cell lung cancer (NSCLC) tumorsCell lung cancer tumorsLung cancer tumorsSingle dosesTumor hypoxiaTreatment failureNSCLC tumorsBlood ratioHypoxic volumeRadiation therapyDay 2F-fluoromisonidazole (FMISO) positron emission tomographyCancer tumorsInstitutional review board-approved studyTumor vascular responseBody radiation therapyBoard-approved studyConventional radiation therapyPositron emission tomographyBaseline hypoxiaDetectable hypoxiaNSCLC patients
2006
Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa)
Carlson DJ, Stewart RD, Semenenko VA. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa). Medical Physics 2006, 33: 3105-3115. PMID: 17022202, DOI: 10.1118/1.2229427.Peer-Reviewed Original ResearchConceptsSurvival dataHypoxic cellsOxygen enhancement ratioPatient survival dataIntrinsic radiation sensitivityPoor treatment prognosisSublethal damage repairTumor controlHypoxic subvolumesCervix cancerClinical dataRadiosensitivity parametersTreatment prognosisAerobic cellsDoseDecreased sensitivityHypoxiaEnhancement ratioHypoxicTumorsAlpha/CellsLow-LET radiationTumor regionRadiation sensitivity
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