2020
Variance‐based sensitivity analysis for uncertainties in proton therapy: A framework to assess the effect of simultaneous uncertainties in range, positioning, and RBE model predictions on RBE‐weighted dose distributions
Hofmaier J, Dedes G, Carlson DJ, Parodi K, Belka C, Kamp F. Variance‐based sensitivity analysis for uncertainties in proton therapy: A framework to assess the effect of simultaneous uncertainties in range, positioning, and RBE model predictions on RBE‐weighted dose distributions. Medical Physics 2020, 48: 805-818. PMID: 33210739, DOI: 10.1002/mp.14596.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceHumansMaleProton TherapyRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessUncertaintyA new approach to modeling the microdosimetry of proton therapy beams
Abolfath R, Helo Y, Carlson DJ, Stewart R, Grosshans D, Mohan R. A new approach to modeling the microdosimetry of proton therapy beams. Medical Physics 2020, 47: 3184-3190. PMID: 32249429, PMCID: PMC10019905, DOI: 10.1002/mp.14165.Peer-Reviewed Original ResearchModeling RBE‐weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams
Meschini G, Kamp F, Hofmaier J, Reiner M, Sharp G, Paganetti H, Belka C, Wilkens JJ, Carlson DJ, Parodi K, Baroni G, Riboldi M. Modeling RBE‐weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams. Medical Physics 2020, 47: 2768-2778. PMID: 32162332, DOI: 10.1002/mp.14135.Peer-Reviewed Original ResearchMeSH KeywordsCarbonFour-Dimensional Computed TomographyHumansLung NeoplasmsPhantoms, ImagingRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessConceptsEstimation errorIrregular breathing motionIon beamSoft tissue deformationMotion effectsRespiratory motion modelTissue deformationMotion modelCarbon ion beamsProper accuracyWater equivalent depthBreathing motionMedian estimation errorSimulationsPhantom validationEquivalent depthEffects of motionEquivalent uniform doseMotionAbdominal targetsBeamRespiratory motionScanned carbon ion beamsAccuracy decreasesLarge values
2019
Dosimetric accuracy and radiobiological implications of ion computed tomography for proton therapy treatment planning
Meyer S, Kamp F, Tessonnier T, Mairani A, Belka C, Carlson DJ, Gianoli C, Parodi K. Dosimetric accuracy and radiobiological implications of ion computed tomography for proton therapy treatment planning. Physics In Medicine And Biology 2019, 64: 125008. PMID: 30870831, DOI: 10.1088/1361-6560/ab0fdf.Peer-Reviewed Original ResearchMeSH KeywordsCarbonDNA Breaks, Double-StrandedHeliumHumansMonte Carlo MethodProton TherapyRadiobiologyRadiometryRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessTomographyConceptsX-ray CTCalculation accuracyRSP accuracyDosimetric accuracyFLUKA Monte Carlo simulationsPotential replacementFixation modelProton therapy treatment planningProton CTModel predictionsIon therapy treatmentsConventional X-ray CTHeliumHigh accuracyBetter performanceCommon uncertaintyTracking detectorMonte Carlo simulationsAccuracyImaging doseSoft tissueHigh-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay
Tien CJ, Carlson DJ, Nath R, Chen ZJ. High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay. Brachytherapy 2019, 18: 701-710. PMID: 31109870, DOI: 10.1016/j.brachy.2019.04.005.Peer-Reviewed Original ResearchReport of the AAPM TG‐256 on the relative biological effectiveness of proton beams in radiation therapy
Paganetti H, Blakely E, Carabe‐Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG‐256 on the relative biological effectiveness of proton beams in radiation therapy. Medical Physics 2019, 46: e53-e78. PMID: 30661238, PMCID: PMC9559855, DOI: 10.1002/mp.13390.Peer-Reviewed Original ResearchHumansNeoplasmsPractice Guidelines as TopicProton TherapyRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessResearch Report
2018
A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies
Guan F, Geng C, Carlson DJ, H D, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Physics In Medicine And Biology 2018, 64: 015008. PMID: 30523805, DOI: 10.1088/1361-6560/aaf5df.Peer-Reviewed Original ResearchAlgorithmsHeavy Ion RadiotherapyHumansMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedRelative Biological Effectiveness
2017
Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy
Kamp F, Carlson DJ, Wilkens JJ. Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy. Physics In Medicine And Biology 2017, 62: n285-n296. PMID: 28561011, DOI: 10.1088/1361-6560/aa716b.Peer-Reviewed Original ResearchHeavy Ion RadiotherapyHumansModels, BiologicalRadiation ToleranceRadiotherapy Planning, Computer-AssistedRelative Biological EffectivenessTime FactorsUncertainty
2016
The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery.
Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. Journal Of Neurosurgery 2016, 125: 154-159. PMID: 27903196, DOI: 10.3171/2016.6.gks161497.Peer-Reviewed Original ResearchMeSH KeywordsCobalt RadioisotopesHumansRadiosurgeryRadiotherapy DosageRelative Biological EffectivenessConceptsTrigeminal neuralgiaGKRS treatmentObsessive-compulsive disorderTN managementEffective doseRefractory obsessive-compulsive disorderGamma Knife radiosurgery proceduresStudy of patientsGamma knife radiosurgeryRates of toxicitySingle-fraction dosesStudy of outcomesNerve ablationSerious sequelaePrescription dosesKnife radiosurgeryPrescription doseClinical studiesConclusion UseGKRSDose prescriptionGy/minRepair halftimeTreatment timeAuthors' departmentBiologically optimized helium ion plans: calculation approach and its in vitro validation
Mairani A, Dokic I, Magro G, Tessonnier T, Kamp F, Carlson DJ, Ciocca M, Cerutti F, Sala PR, Ferrari A, Böhlen TT, Jäkel O, Parodi K, Debus J, Abdollahi A, Haberer T. Biologically optimized helium ion plans: calculation approach and its in vitro validation. Physics In Medicine And Biology 2016, 61: 4283-4299. PMID: 27203864, DOI: 10.1088/0031-9155/61/11/4283.Peer-Reviewed Original ResearchAlgorithmsCell Line, TumorCell SurvivalHeliumHumansRadioisotopesRadiotherapy Planning, Computer-AssistedRelative Biological Effectiveness
2015
Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictionsExtension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints
Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Physics In Medicine And Biology 2015, 60: 5053-5070. PMID: 26061666, PMCID: PMC4511084, DOI: 10.1088/0031-9155/60/13/5053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCricetinaeCricetulusDNA Breaks, Double-StrandedElectronsHumansLinear Energy TransferMonte Carlo MethodProton TherapyProtonsRelative Biological EffectivenessSoftwareConceptsFrequency-mean specific energyProton linear energy transferProton radiation effectsMonte Carlo toolLinear energy transferDelta electronsLineal energyProton RBEBragg peakPhysics parametersRadiobiological experimentsExperimental arrangementEnergy transferTOPASRadiation effectsTrack structureBiological input parametersProton therapyExperimental dataDouble-strand break inductionDNA double-strand break inductionEnergyRBEElectronsSpecific geometry
2014
The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?
Brown JM, Carlson DJ, Brenner DJ. The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved? International Journal Of Radiation Oncology • Biology • Physics 2014, 88: 254-262. PMID: 24411596, PMCID: PMC3893711, DOI: 10.1016/j.ijrobp.2013.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCell CycleCell HypoxiaCell ProliferationCell SurvivalDNA DamageDNA RepairDose Fractionation, RadiationEndothelial CellsHumansLinear ModelsMelanomaMiceModels, BiologicalNeoplasmsOxygen ConsumptionRadiation ToleranceRadiobiologyRadiosurgeryRelative Biological Effectiveness
2011
A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy
Frese MC, Yu VK, Stewart RD, Carlson DJ. A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 442-450. PMID: 22099045, DOI: 10.1016/j.ijrobp.2011.06.1983.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCarbonCell SurvivalDNA Breaks, Double-StrandedDNA RepairHumansLinear Energy TransferLinear ModelsMonte Carlo MethodProton TherapyRadiation ToleranceRelative Biological EffectivenessSoftwareConceptsRelative biological effectivenessCarbon ionsRadiation qualityUniform biological effectIon kinetic energyBiological effectivenessMonte Carlo modelParticle energyRMF modelBragg peakMonte Carlo damage simulation (MCDS) softwareCarlo modelRelevant protonsLinear-quadratic parametersKinetic energyProton relative biological effectivenessProtonsPhysical doseParticle distributionIonsParameter αEnergyRepresentative spreadSOBPPotential biological advantagesEffects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death
Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death. Radiation Research 2011, 176: 587-602. PMID: 21823972, DOI: 10.1667/rr2663.1.Peer-Reviewed Original Research
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