2025
Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility
Mollon J, Schultz L, Knowles E, Jacquemont S, Glahn D, Almasy L. Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility. Biological Psychiatry 2025 PMID: 40113122, DOI: 10.1016/j.biopsych.2025.03.006.Peer-Reviewed Original ResearchAlcohol use disorderPolygenic risk scoresSchizophrenia polygenic risk scoresPercentage of individualsHigh riskDepressive disorderLack of clinical utilityUse disorderValidity of polygenic risk scoresSchizophreniaClinical utilityMDDRisk scoreEffect sizeSNP effect sizesWhite British individualsDisordersHigh-risk individualsUK BiobankType 2 diabetesBritish individualsPRS-CSIndividualsT2DPsychiatry
2024
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz L, Knowles E, Cox S, Porteous D, Davies G, Redmond P, Harris S, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer S, Sebat J, Almasy L, Glahn D, Jacquemont S. Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genomics 2024, 4: 100721. PMID: 39667348, PMCID: PMC11701252, DOI: 10.1016/j.xgen.2024.100721.Peer-Reviewed Original ResearchConceptsCopy-number variantsGenome-wide association studiesAssociation studiesCognitive abilitiesBiological processesEffect of gene dosageNeurodevelopmental disordersAssociated with cognitionHigher cognitive performanceGene dosageGene setsAssociated with higher cognitive performanceCognitive performanceGenesCell typesEffect sizeCognitionDeletionDuplicationDisordersNon-brain tissuesMedical comorbiditiesAbilityVariantsBrainRESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS
Kochunov P, Nichols T, Blangero J, Medland S, Glahn D, Hong E. RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 21-22. DOI: 10.1016/j.euroneuro.2024.08.056.Peer-Reviewed Original ResearchGenetic analysisGenome-wide associationBrain patternsImaging genetic analysisImaging genetic datasetGenetic resolutionGenetic risk factorsGenetic datasetsGenetic dataDepressive disorderPsychiatric disordersRisk of development of dementiaVariance componentsHigh-resolution neuroimagingDevelopment of dementiaNurturing interactionsEnvironmental risk factorsAlzheimer's diseaseGenetic correlationsRisk factorsTreatment effectsDisordersLongitudinal datasetPsychosisSNPsNeurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Jiang Y, Luo C, Wang J, Palaniyappan L, Chang X, Xiang S, Zhang J, Duan M, Huang H, Gaser C, Nemoto K, Miura K, Hashimoto R, Westlye L, Richard G, Fernandez-Cabello S, Parker N, Andreassen O, Kircher T, Nenadić I, Stein F, Thomas-Odenthal F, Teutenberg L, Usemann P, Dannlowski U, Hahn T, Grotegerd D, Meinert S, Lencer R, Tang Y, Zhang T, Li C, Yue W, Zhang Y, Yu X, Zhou E, Lin C, Tsai S, Rodrigue A, Glahn D, Pearlson G, Blangero J, Karuk A, Pomarol-Clotet E, Salvador R, Fuentes-Claramonte P, Garcia-León M, Spalletta G, Piras F, Vecchio D, Banaj N, Cheng J, Liu Z, Yang J, Gonul A, Uslu O, Burhanoglu B, Uyar Demir A, Rootes-Murdy K, Calhoun V, Sim K, Green M, Quidé Y, Chung Y, Kim W, Sponheim S, Demro C, Ramsay I, Iasevoli F, de Bartolomeis A, Barone A, Ciccarelli M, Brunetti A, Cocozza S, Pontillo G, Tranfa M, Park M, Kirschner M, Georgiadis F, Kaiser S, Van Rheenen T, Rossell S, Hughes M, Woods W, Carruthers S, Sumner P, Ringin E, Spaniel F, Skoch A, Tomecek D, Homan P, Homan S, Omlor W, Cecere G, Nguyen D, Preda A, Thomopoulos S, Jahanshad N, Cui L, Yao D, Thompson P, Turner J, van Erp T, Cheng W, Feng J. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nature Communications 2024, 15: 5996. PMID: 39013848, PMCID: PMC11252381, DOI: 10.1038/s41467-024-50267-3.Peer-Reviewed Original ResearchConceptsGray matter changesDisorder constructsEnlarged striatumPsychiatric conditionsMental disordersSubcortical regionsSchizophreniaBiological foundationsMatter changesBrain imagingStriatumDisordersBiological factorsIndividualsSubtypesHealthy subjectsCross-sectional brain imagingHippocampusTemporal trajectoriesInternational cohortSubgroup 2Subgroup 1Subgroups8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites
Nabulsi L, Kang M, Jahanshad N, Haarman B, McDonald C, Stein D, Glahn D, Pomarol-Clotet E, Vieta E, Houenou J, Favre P, Polosan M, Brambilla P, Bellani M, Mitchell P, Dannlowski U, Wessa M, Phillips M, Kircher T, Thompson P, Andreassen O, Ching C, Cannon D, Group E. 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites. Biological Psychiatry 2024, 95: s76-s77. DOI: 10.1016/j.biopsych.2024.02.186.Peer-Reviewed Original Research
2016
Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience
Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.Peer-Reviewed Original ResearchPsychiatric disordersMechanisms of psychiatric disordersModel psychiatric disordersPsychiatric nosologyPsychological assessmentPsychiatric diagnosingModern psychiatryPsychiatric issuesNeurobiologyPsychiatristsNeurological analysisPsychiatryDisordersComputational neuroscienceClinical heterogeneityNeuroimagingNosologyNeuroscienceNeuroscientistsComputational neuroscientistsCategorization
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