2024
Impact of Type 2 Diabetes and Hypertension on Cognition: A Propensity Score‐Matched Analysis in Mexican Americans from San Antonio
Lopez‐Alvarenga J, Almeida M, Cavazos J, Mahaney M, Maestre G, Glahn D, Duggirala R, Blangero J. Impact of Type 2 Diabetes and Hypertension on Cognition: A Propensity Score‐Matched Analysis in Mexican Americans from San Antonio. Alzheimer's & Dementia 2024, 20: e091135. PMCID: PMC11716190, DOI: 10.1002/alz.091135.Peer-Reviewed Original ResearchCalifornia Verbal Learning TestContinuous Performance TestHigh blood pressureCalifornia Verbal Learning Test scoresMexican AmericansVerbal Learning TestInformation-processing speedAffected cognitive domainsPrevalence of chronic conditionsCognitive screening toolHigh blood pressure statusUS Hispanic/Latino populationEpidemiological observational studiesObservational studyExecutive functionLearning TestCognitive measuresDelayed recallEffect of T2DMemory delayShort-term memoryImpact of type 2 diabetesRisk of hypertensionCognitive functionLow processing speedAdmixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos
Xia R, Jian X, Rodrigue A, Bressler J, Boerwinkle E, Cui B, Daviglus M, DeCarli C, Gallo L, Glahn D, Knowles E, Moon J, Mosley T, Satizabal C, Sofer T, Tarraf W, Testai F, Blangero J, Seshadri S, González H, Fornage M. Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. Alzheimer's & Dementia 2024, 20: 6070-6081. PMID: 38946675, PMCID: PMC11497725, DOI: 10.1002/alz.14082.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLatino adultsAssociated to cognitive functionAdmixture mappingHispanic Community Health Study/Study of LatinosCognitive functionHispanic Community Health Study/StudyPrioritized single nucleotide polymorphismsGenetic variantsGenome-wide association studiesNon-Hispanic whitesFine-mapping analysisLoci harboring genesSample of BlackHispanic/Latino adultsPhosphoinositide lipid metabolismNeurocognitive measuresIndependent replicationAdmixture signalsUnique haplotypesGenetic architectureChromosomal regionsHarboring genesAssociation studiesNucleotide polymorphisms
2017
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group
Brouwer R, Panizzon M, Glahn D, Hibar D, Hua X, Jahanshad N, Abramovic L, de Zubicaray G, Franz C, Hansell N, Hickie I, Koenis M, Martin N, Mather K, McMahon K, Schnack H, Strike L, Swagerman S, Thalamuthu A, Wen W, Gilmore J, Gogtay N, Kahn R, Sachdev P, Wright M, Boomsma D, Kremen W, Thompson P, Pol H. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human Brain Mapping 2017, 38: 4444-4458. PMID: 28580697, PMCID: PMC5572837, DOI: 10.1002/hbm.23672.Peer-Reviewed Original ResearchConceptsSubcortical brain volumesBrain volumeGenetic influencesBrain changesBrain structuresDevelopmental trajectory of brain structureDeviant developmental trajectoriesMultivariate genetic modelsGeneral cognitive functionStructural brain changesBrain structural changesLongitudinal twin cohortCerebellar gray matterInfluence of genetic factorsSubcortical volumesCognitive functionBaseline volumeBrain plasticityHeritability estimatesDevelopmental changesMental healthBrain developmentTwin cohortEnvironmental influencesGray matter
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