Featured Publications
Using Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis
Feizi A, Bell C, Roytman G, Park N, Wang A, Tommasini S, Wiznia D. Using Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis. Arthroplasty Today 2024, 26: 101337. PMID: 38497084, PMCID: PMC10940782, DOI: 10.1016/j.artd.2024.101337.Peer-Reviewed Original ResearchFemoral head avascular necrosisAvascular necrosisSurgical techniqueCore decompressionBone marrow aspirate concentrateDelay disease progressionOutcome of core decompressionAdjuvant therapyCellular therapyAspirate concentrateDisease progressionFemoral head collapseImprove outcomesLesionsDebilitating conditionTherapyComputer navigationNecrosisDecompressionHead collapseThree-dimensional modelFemoral head
2025
Pure high-offset stems can cause an unexpected increase in femoral length in robotic-assisted primary total hip arthroplasty
Tung W, Pour A, Sieberer J, Donnelley C, Tommasini S, Wiznia D. Pure high-offset stems can cause an unexpected increase in femoral length in robotic-assisted primary total hip arthroplasty. World Journal Of Orthopedics 2025, 16: 107292. PMID: 40547237, PMCID: PMC12179884, DOI: 10.5312/wjo.v16.i6.107292.Peer-Reviewed Original Research115,000 Miles and Counting: Extraordinary Athletic Activity After a Historic Total HipArthroplasty with 39-year Follow-up
Gilmore M, Khwaja A, Wiznia D, Rubin L. 115,000 Miles and Counting: Extraordinary Athletic Activity After a Historic Total HipArthroplasty with 39-year Follow-up. Arthroplasty Today 2025, 33: 101711. PMID: 40548308, PMCID: PMC12182318, DOI: 10.1016/j.artd.2025.101711.Peer-Reviewed Original ResearchRisk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study
Roytman G, Lahik S, Tommasini S, Wiznia D, Fram B. Risk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study. Journal Of Orthopaedic Research® 2025 PMID: 40443200, DOI: 10.1002/jor.26113.Peer-Reviewed Original ResearchSingle-leg stanceAntegrade intramedullary nailingTip terminationMaximum stressFinite element modelFinite element studyFemur fracturesDistal femur fracturesExtent of failureElement modelLoading scenariosBody weight loadElement studyIntramedullary nail fixationProximal femur fracturesOsteoporotic femursRisk of peri-implant fractureNail fixationWeight loadingIntramedullary nailingLoadPeri-implant fracturesGeriatric patientsOrthopaedic Centers May Require Additional Support to Meet the 2024 TJC and CMS SDOH Requirements
Darby F, Rancu A, Nishime N, Kurek D, Wiznia D. Orthopaedic Centers May Require Additional Support to Meet the 2024 TJC and CMS SDOH Requirements. Orthopaedic Nursing 2025, 44: 184-192. PMID: 40466120, DOI: 10.1097/nor.0000000000001117.Peer-Reviewed Original ResearchConceptsSocial determinants of healthOrthopaedic nursesCenters for Medicare & Medicaid ServicesDeterminants of healthWritten action planScreening requirementsElectronic medical recordsNursing staffSocial determinantsJoint CommissionHealthcare organizationsHospital administratorsMedicaid ServicesNursesSurvey questionsMedical recordsIncreased communicationInstitutional preparednessAction planPreparednessScreeningHealthStaffTJCOrganizational responsesThe implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study
Singh M, Jester N, Lorr S, Briano A, Schwartz N, Mahajan A, Chiang V, Tommasini S, Wiznia D, Buono F. The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study. Clinical Imaging 2025, 123: 110495. PMID: 40388858, DOI: 10.1016/j.clinimag.2025.110495.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryVestibular schwannomaPost-GKSTumor growthVS volumeHalting tumor growthRetrospective cohort studyAssess treatment efficacyManual segmentationHearing lossBenign tumorsPaired t-testT1-weighted MRI scansAssess statistical significanceCohort studyDice similarity coefficientNeurological functionTreatment efficacyClinical monitoringMRI scansStatistical significancePercentage changeSchwannomaSpatial overlapTumor3D Analysis of the Proximal Radial Shaft and its Intermedullary Canal: A Cadaver Imaging Study
Sieberer J, Cobo M, Rancu A, LaMonica J, Brennan K, Copes L, Tommasini S, Wiznia D, Lattanza L. 3D Analysis of the Proximal Radial Shaft and its Intermedullary Canal: A Cadaver Imaging Study. JSES International 2025 DOI: 10.1016/j.jseint.2025.04.026.Peer-Reviewed Original ResearchPatellar tilt calculation utilizing artificial intelligence on CT knee imaging
Sieberer J, Rancu A, Park N, Desroches S, Manafzadeh A, Tommasini S, Wiznia D, Fulkerson J. Patellar tilt calculation utilizing artificial intelligence on CT knee imaging. The Knee 2025, 54: 217-221. PMID: 40086415, DOI: 10.1016/j.knee.2025.02.019.Peer-Reviewed Original ResearchConceptsPatellar tiltDiagnosis of patellar instabilityMann-Whitney U testInterclass correlation coefficientKruskal-Wallis testCommercial AI algorithmsNo significant differenceCT scanPatellar instabilityMann-WhitneyU testAnatomical landmarksKruskal-WallisPatientsSignificant differencePatellofemoral diseaseConfidence intervalsBonferroni methodDislocation eventsCorrelation coefficientDisparities in Social Determinants of Health Associated With Decreased Likelihood of Receiving Total Joint Arthroplasty.
Kim L, Nishime N, Ansah-Twum J, Grauer J, Wiznia D. Disparities in Social Determinants of Health Associated With Decreased Likelihood of Receiving Total Joint Arthroplasty. Journal Of The American Academy Of Orthopaedic Surgeons 2025 PMID: 40063682, DOI: 10.5435/jaaos-d-24-00945.Peer-Reviewed Original ResearchSocial determinants of healthSocial determinants of health disparitiesIndividual social determinants of healthSocial determinants of health categoriesSocial determinants of health screeningTotal joint arthroplastyFinancial strainDeterminants of healthSpecialized health careDiagnosis of kneeRates of total joint arthroplastyMultivariate logistic regressionTransportation insecuritySocial determinantsOrthopaedic careHealth careKnee osteoarthritisHip OAOrthopaedic conditionsDecreased oddsHip osteoarthritisLogistic regressionFood insecurityDisparitiesKneePersonalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect
Bergemann R, Massey A, Tommasini S, Wiznia D. Personalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect. Journal Of Orthopaedic Surgery And Research 2025, 20: 229. PMID: 40033401, PMCID: PMC11874654, DOI: 10.1186/s13018-025-05606-5.Peer-Reviewed Original ResearchConceptsAdjunctive therapyVolume of boneCore decompressionBone marrow aspirate concentrateRisk of complicationsFemoral headSynthetic bone substituteAmount of boneBone substituteAspirate concentrateExpandable reamerBone regenerationBone graftPrevent collapseDebilitating diseaseReamer systemBoneAdjunctGrafting techniqueDecompressionThe development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas
Jester N, Singh M, Lorr S, Tommasini S, Wiznia D, Buono F. The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas. Scientific Reports 2025, 15: 5918. PMID: 39966622, PMCID: PMC11836447, DOI: 10.1038/s41598-025-88589-x.Peer-Reviewed Original ResearchConceptsGround-truth datasetDice scoreVestibular schwannomaImage processing accuracyVolumetric analysisML-based algorithmsMeasuring tumor sizeMean dice scoreAuto-segmentation toolAccurate AIAI modelsTumor sizeTumor modelVS tumorsTumor growthTesting stageAI-LTumorImage processing softwareClinical practicePatient recruitmentProcessing softwareSchwannomaDatasetManual segmentationCD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections
Agidigbi T, Fram B, Molloy I, Riedel M, Wiznia D, Oh I. CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections. Clinical Orthopaedics And Related Research® 2025, 483: 1062-1071. PMID: 39915095, PMCID: PMC12106227, DOI: 10.1097/corr.0000000000003402.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsFracture-related infectionRibonucleotide reductase regulatory subunit M2Peripheral blood mononuclear cell levelsPeripheral blood mononuclear cell concentrationsPeriprosthetic joint infectionMusculoskeletal infectionsMonitoring treatment responseDiabetic foot infectionsTreatment responseReceiver operating characteristicPurulent drainageControl groupSerum levelsSinus tractInflammatory markersBlood samplesFoot infectionsInfection groupDiagnostic accuracyTranscriptomic analysis of peripheral blood mononuclear cellsDiagnosis of musculoskeletal infectionsNormalization of inflammatory markersPeripheral blood mononuclear cells of patientsInflammatory conditionsMusculoskeletal Magazine Advertising Focuses on White Individuals and Overlooks Minority Consumers
Tung W, Rankin K, Oris R, Wijesekera A, Wiznia D. Musculoskeletal Magazine Advertising Focuses on White Individuals and Overlooks Minority Consumers. Journal Of Market Access & Health Policy 2025, 13: 4. PMID: 39990185, PMCID: PMC11843984, DOI: 10.3390/jmahp13010004.Peer-Reviewed Original ResearchHealth-related advertisingImprove patient perceptionsUS population demographicsDirect-to-consumer advertisingAdvertising categoriesCross-sectional analysisBlack modelHealth disparitiesHealth existChi-square testInfluence consumer behaviorWhite individualsWhite modelFisher's exact testDemographic disparitiesDisparitiesPain reliefBuying patternsConsumer behaviorMinority consumersPopulation demographicsExact testRacial distributionAdjacent industriesMSKMedical Student Musculoskeletal Knowledge: Examining the Impact and Value of an Orthopaedic Surgery Clerkship Using the Freedman and Bernstein Examination
Nishime N, Seibel M, Lindskog D, Wiznia D. Medical Student Musculoskeletal Knowledge: Examining the Impact and Value of an Orthopaedic Surgery Clerkship Using the Freedman and Bernstein Examination. BMC Medical Education 2025, 25: 141. PMID: 39881308, PMCID: PMC11776173, DOI: 10.1186/s12909-025-06673-2.Peer-Reviewed Original ResearchConceptsMusculoskeletal knowledgePost-test scoresMusculoskeletal examinationPost-testPre-testSurgery clerkshipThree-week clerkshipPost-clerkship surveysOrthopaedic surgery departmentsOrthopaedic surgery residentsMedical schoolsMethodsMedical studentsSurgery departmentClerkshipSurgery residentsAverage scoreRaw scoresScoresWeighted scoreOrthopaedicsExaminationClinician Perspectives of an MRI-Based 3D Volumetric Analysis Tool for NF2-Related Schwannamatosis: Qualitative Pilot Study (Preprint)
Desroches S, Huang A, Ghankot R, Tommasini S, Wiznia D, Buono F. Clinician Perspectives of an MRI-Based 3D Volumetric Analysis Tool for NF2-Related Schwannamatosis: Qualitative Pilot Study (Preprint). JMIR Human Factors 2025 DOI: 10.2196/71728.Peer-Reviewed Original ResearchTau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei Z, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia D, Xu H, Chen Z, Chen L, Tang K, Zhou H, Liu C. Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Cell Research 2025, 35: 23-44. PMID: 39743632, PMCID: PMC11701132, DOI: 10.1038/s41422-024-01016-0.Peer-Reviewed Original ResearchConceptsGC-induced osteoporosisBone lossInflammatory arthritisAdverse effects of dexamethasoneGlucocorticoid-induced bone lossHigh-dose dexamethasoneEffect of dexamethasoneFDA-approved drug librarySynthetic GCTreat inflammatory arthritisImmunosuppressive drugsPrescribed anti-inflammatoryGC receptorCombinatorial administrationSide effectsLow affinityGlucocorticoidOsteoporosisDexamethasoneReceptorsAdverse effectsBinding receptorsAnti-inflammatoryDrug libraryTau deficiency
2024
Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion.
Kim L, Wiznia D, Grauer J. Patients With Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors Undergoing Total Knee Arthroplasty Are at Increased Odds for a Number of Postoperative Adverse Events But Reduced Risk of Transfusion. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39630933, DOI: 10.5435/jaaos-d-24-00299.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitorsDM patientsAdverse eventsDiabetes mellitusTotal knee arthroplastySGLT2i useElixhauser Comorbidity IndexComorbidity indexMultivariate analysisIncidence of blood transfusionReduced risk of transfusionAssociated with multiple complicationsOdds of transfusionUrinary tract infectionAssociated with increased riskPerioperative adverse outcomesRisk of transfusionAssociated with reduced incidenceAcute kidney injuryPostoperative adverse eventsSurgical decision makingControlled DM patientsActive tobacco useGroup of medicationsAssociated with higher oddsMethods to Manage Edema and Reduce Flap Compression in Postoperative Nursing Care Following Trauma to the Lower Extremity
Rancu A, Darby F, Averbukh L, Nicholson A, Myrick K, Leslie M, Wiznia D. Methods to Manage Edema and Reduce Flap Compression in Postoperative Nursing Care Following Trauma to the Lower Extremity. Orthopaedic Nursing 2024, 43: 325-329. PMID: 39630519, DOI: 10.1097/nor.0000000000001075.Peer-Reviewed Original Research In PressConceptsLower extremity traumaExtremity traumaAcute care settingPostoperative nursing careNurse managersOrthopaedic nursesNursing careSoft tissue coverage techniquesPostoperative nursing managementCare settingsLower-extremitySoft tissue coverage proceduresLower extremitiesReduce edemaPoor soft tissue healingTraumatic injuryLiterature reviewTraumaNursesExtremitiesLower extremity edemaPatientsCareSoft tissue healingReviewImpact of Surgeon Volume on Perioperative Complications and Survival to Total Hip Arthroplasty Following Femoral Head Core Decompression
Sanchez J, Jiang W, Dhodapkar M, Radford Z, Seddio A, Li M, Wiznia D, Grauer J. Impact of Surgeon Volume on Perioperative Complications and Survival to Total Hip Arthroplasty Following Femoral Head Core Decompression. JAAOS Global Research And Reviews 2024, 8: e24.00153. PMCID: PMC11578193, DOI: 10.5435/jaaosglobal-d-24-00153.Peer-Reviewed Original ResearchFemoral head osteonecrosisHip fractureInvasive proceduresCore decompressionHigh-volume surgeon groupImpact of surgeon volumeTotal hip arthroplastyKaplan-Meier survival analysisHigh-volume surgeonsMinimally invasive procedureSurgeon volume categoriesStatistically significant differenceAssess complicationsPerioperative complicationsPostoperative complicationsElixhauser Comorbidity IndexAdult patientsVolume surgeonsTreatment optionsAdverse eventsSurgeon volumeSurgeon groupComorbidity indexMultivariate analysisComplicationsVisualization of Trochlear Dysplasia Using 3-Dimensional Curvature Analysis in Patients With Patellar Instability Facilitates Understanding and Improves the Reliability of the Entry Point to Trochlea Groove Angle
Sieberer J, Park N, Manafzadeh A, Desroches S, Brennan K, McDonald C, Tommasini S, Wiznia D, Fulkerson J. Visualization of Trochlear Dysplasia Using 3-Dimensional Curvature Analysis in Patients With Patellar Instability Facilitates Understanding and Improves the Reliability of the Entry Point to Trochlea Groove Angle. Arthroscopy Sports Medicine And Rehabilitation 2024, 7: 101010. PMID: 40041820, PMCID: PMC11873473, DOI: 10.1016/j.asmr.2024.101010.Peer-Reviewed Original ResearchPatellofemoral instability patientsInterclass correlation coefficientInterrater reliabilityPatellofemoral instabilityLevel III-retrospective cohort studyResults Qualitative analysisIII-retrospective cohort studyTrochlear grooveClinical decision-makingRetrospective cohort studyAge-sex matched controlsCohort studyMann-Whitney U testAge-sexRecurrent patellar instabilityPatient's kneeControl kneesAP viewMatched controlsKneePatellar instabilityCT scanTrochlear dysplasiaMann-WhitneyU test
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