2012
Radial Construction of an Arterial Wall
Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial Construction of an Arterial Wall. Developmental Cell 2012, 23: 482-493. PMID: 22975322, PMCID: PMC3500096, DOI: 10.1016/j.devcel.2012.07.009.Peer-Reviewed Original ResearchConceptsInner layer cellsCoordinated processGenetic analysisSuccessive cell layersVessel-specific differencesSignaling pathwaysCell reorientationSequential inductionEndothelial tubesSignal gradientMuscle cellsSignal contributesSerious diseaseCellsCell layerLayer cellsRadial migrationMesenchymeConcentric layersPathwayArterial wallPDGFInvasionInductionArtery wall
2004
Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis
Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1165-1170. PMID: 14736917, PMCID: PMC337024, DOI: 10.1073/pnas.0306377101.Peer-Reviewed Original ResearchConceptsPhosphorylation of CaMBovine aortic endothelial cellsCaM phosphorylationCaM mutantsCalcium regulatory protein calmodulinBiosynthetic labelingRegulation of eNOSProtein kinase pathwayEndothelial NO synthaseSer-81Regulatory protein calmodulinKinase CK2Kinase pathwayEndothelial cellsCK2Protein calmodulinMutantsCalmodulin phosphorylationPhosphorylationAortic endothelial cellsPhenyl-SepharoseUnique pathwayENOS activationMutant CaMPathway