2025
Îł-secretase facilitates retromer-mediated retrograde transport
Takeo Y, Crite M, Mehmood K, DiMaio D. Îł-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkTransport of protein cargoRetrograde protein traffickingCation-independent mannose-6-phosphate receptorCellular transmembrane proteinsMannose-6-phosphate receptorAssociation with cargoHuman epithelial cellsBinds retromerRetromer subunitsRetromer cargoRab7-GTPShiga toxinRetrograde transportCultured human epithelial cellsProtein traffickingRetromerCatalytic subunitTransmembrane domainTransmembrane proteinsProtein cargoCellular cargoTarget proteinsFunctional consequencesCholera toxin
2013
Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus
Lipovsky A, Popa A, Pimienta G, Wyler M, Bhan A, Kuruvilla L, Guie MA, Poffenberger AC, Nelson CD, Atwood WJ, DiMaio D. Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7452-7457. PMID: 23569269, PMCID: PMC3645514, DOI: 10.1073/pnas.1302164110.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkHPV entryGenome-wide screenRetromer subunitsCellular genesScreen identifiesRetromerLate endosomesPotential antiviral targetsMultiple subunitsRetrograde pathwayTransport factorsCapsid proteinHeLa cellsCell entryAntiviral targetEndosomesGolgiVirus entryStable complexesEfficient infectionSubunitsHPV proteinsProteinImportant insights
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