2017
Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH
Rao JU, Coman D, Walsh JJ, Ali MM, Huang Y, Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH. Scientific Reports 2017, 7: 7865. PMID: 28801587, PMCID: PMC5554228, DOI: 10.1038/s41598-017-07609-7.Peer-Reviewed Original ResearchConceptsU251 tumorsTumor microenvironmentT2-weighted MRITherapeutic responseUntreated ratsTumor volumeRat brainTumor growthTherapeutic influenceGlioma growthPeritumoral regionRatsApoptosis inductionTumorsGliomasTumor corePhysiological readoutsExtracellular pHAcidic pHeTumor boundariesProliferationMicroenvironment
2014
Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl
2007
Energetics of neuronal signaling and fMRI activity
Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20546-20551. PMID: 18079290, PMCID: PMC2154468, DOI: 10.1073/pnas.0709515104.Peer-Reviewed Original ResearchConceptsRSN activityContralateral S1FMRI activationBaseline stateContralateral primary somatosensory cortexPrimary somatosensory cortexSomatosensory cortexIntracortical interactionsFiring rateNeuronal signalingFMRI activityEnsemble activityEnsemble firingStimulationHalothaneCortexNeuronsBaselineActivationFMRI dataLarge majorityAnesthesiaActivityRats