2018
Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor
Wei J, Fu W, Hettinghouse A, He W, Lipson K, Liu C. Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor. Arthritis & Rheumatology 2018, 70: 1745-1756. PMID: 29750395, PMCID: PMC6203634, DOI: 10.1002/art.40552.Peer-Reviewed Original ResearchConceptsConnective tissue growth factorCIA mouse modelADAMTS-12Inflammatory arthritisTissue growth factorMouse modelCollagen-induced arthritis modelGrowth factorRheumatoid arthritis developmentEnzyme-linked immunosorbentRA patientsArthritis developmentPannus formationSerum levelsCartilage destructionArthritis modelInflammatory cytokinesEnhanced osteoclastogenesisHealthy subjectsArthritisAnkle jointTomography scanningInflammationSusceptibility genesCritical regulator
2009
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis
Liu C. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nature Reviews Rheumatology 2009, 5: 38-45. PMID: 19098927, PMCID: PMC4433145, DOI: 10.1038/ncprheum0961.Peer-Reviewed Original Research
2008
Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity
Bai X, Wang D, Luan Y, Yu X, Liu C. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. Cellular And Molecular Life Sciences 2008, 66: 667. PMID: 19151918, PMCID: PMC11131527, DOI: 10.1007/s00018-008-8633-x.Peer-Reviewed Original ResearchConceptsADAMTS-12Chondrocyte differentiationGrowth plate chondrocytesType X collagen expressionThrombospondin motifsPTHrPCollagen expressionAltered expressionMRNA levelsProminent expressionDownstream moleculesADAMTS familyMetalloproteinaseInhibitionEnzymatic activityNovel regulatorProteolytic activityChondrocytesExpressionChondrogenesisDifferentiationActivityInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
Luan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, Di Cesare P, Goldring M, Abramson S, Liu C. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis And Cartilage 2008, 16: 1413-1420. PMID: 18485748, PMCID: PMC2574789, DOI: 10.1016/j.joca.2008.03.017.Peer-Reviewed Original ResearchConceptsCartilage oligomeric matrix proteinADAMTS-7ADAMTS-12COMP degradationOA patientsOligomeric matrix proteinIL-1betaTNF-alphaHuman chondrocytesCartilage explantsCultured cartilage explantsFirst endogenous inhibitorsArthritic patientsTumor necrosisMatrix proteinsCOMP fragmentsPatientsEndogenous inhibitorDependent mannerOsteoarthritisADAMTS familyAntibodiesInhibitionCartilageChondrocytes
2006
ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein*
Liu C, Kong W, Xu K, Luan Y, Ilalov K, Sehgal B, Yu S, Howell R, Di Cesare P. ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein*. Journal Of Biological Chemistry 2006, 281: 15800-15808. PMID: 16611630, PMCID: PMC1483932, DOI: 10.1074/jbc.m513433200.Peer-Reviewed Original ResearchConceptsCartilage oligomeric matrix proteinADAMTS-12Matrix proteinsOligomeric matrix proteinCOMP degradationNoncollagenous matrix componentsSynovium of patientsProgression of arthritisEpidermal growth factor-like repeat domainRepeat domainExtracellular matrix breakdownFunctional domainsArticular cartilageMolecular mechanismsArthritis patientsRheumatoid arthritisSynovial fluidMatrix breakdownArthritisMatrix componentsDegradative fragmentsPatientsSynoviumProteinNormal cartilage