ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein
Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P, Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P. ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. The FASEB Journal 2006, 20: 988-990. PMID: 16585064, PMCID: PMC1483927, DOI: 10.1096/fj.05-3877fje.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS7 ProteinAdultAgedAnimalsArthritis, RheumatoidBinding SitesCartilageCartilage Oligomeric Matrix ProteinExtracellular Matrix ProteinsGene Expression Regulation, EnzymologicGlycoproteinsHumansHydrogen-Ion ConcentrationMatrilin ProteinsMiceMiddle AgedProtein BindingRatsRNA, MessengerSynovial MembraneTwo-Hybrid System TechniquesUp-RegulationZincConceptsCartilage oligomeric matrix proteinMatrix proteinsEpidermal growth factor domainTwo-hybrid screenOligomeric matrix proteinGrowth factor domainRecombinant catalytic domainCatalytic domainRepeat domainFunctional domainsInteraction partnersADAMTS-7Factor domainAmino acidsEnzymatic activityProteinHigh expression