2012
Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA
Lai Y, Yu X, Zhang Y, Tian Q, Song H, Mucignat M, Perris R, Samuels J, Krasnokutsky S, Attur M, Greenberg J, Abramson S, Di Cesare P, Liu C. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis And Cartilage 2012, 20: 854-862. PMID: 22595227, PMCID: PMC3389204, DOI: 10.1016/j.joca.2012.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntirheumatic AgentsArthritis, ExperimentalArthritis, RheumatoidCartilage Oligomeric Matrix ProteinCase-Control StudiesEnzyme-Linked Immunosorbent AssayExtracellular Matrix ProteinsFemaleGlycoproteinsHumansMaleMatrilin ProteinsMethotrexateMiceMice, TransgenicMiddle AgedOsteoarthritisRecombinant Fusion ProteinsSynovial FluidTumor Necrosis Factor-alphaYoung AdultConceptsCollagen-induced arthritisEnzyme-linked immunosorbent assayCapture enzyme-linked immunosorbent assayCOMP fragmentsRA patientsOA patientsRheumatoid arthritisRodent arthritis modelsTherapeutic response predictorsArthritis mouse modelSera of patientsTNF-transgenic miceTransgenic animal modelsEffects of interventionsNovel sandwich enzyme-linked immunosorbent assayAnimal disease modelsSandwich enzyme-linked immunosorbent assayDisease courseSerum levelsArthritis modelTNFα inhibitorsArthritic patientsCOMP levelsMurine modelResponse predictors
2008
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
Luan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, Di Cesare P, Goldring M, Abramson S, Liu C. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis And Cartilage 2008, 16: 1413-1420. PMID: 18485748, PMCID: PMC2574789, DOI: 10.1016/j.joca.2008.03.017.Peer-Reviewed Original ResearchConceptsCartilage oligomeric matrix proteinADAMTS-7ADAMTS-12COMP degradationOA patientsOligomeric matrix proteinIL-1betaTNF-alphaHuman chondrocytesCartilage explantsCultured cartilage explantsFirst endogenous inhibitorsArthritic patientsTumor necrosisMatrix proteinsCOMP fragmentsPatientsEndogenous inhibitorDependent mannerOsteoarthritisADAMTS familyAntibodiesInhibitionCartilageChondrocytes