2025
Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake
Farokhnia M, Tazare J, Pince C, Bruns N, Gray J, Re V, Fiellin D, Kranzler H, Koob G, Justice A, Vendruscolo L, Rentsch C, Leggio L. Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake. Journal Of Clinical Investigation 2025 PMID: 40048376, DOI: 10.1172/jci188314.Peer-Reviewed Original ResearchAlcohol use disorderTreat alcohol use disorderGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsPeptidase-4 inhibitorsDPP-4isOperant oral alcohol self-administrationDPP-4iAlcohol intakeOral alcohol self-administrationBinge-like alcohol drinkingBaseline alcohol use disordersReceptor agonistsAlcohol self-administrationAlcohol-dependent ratsReduce alcohol drinkingAlcohol drinkingGLP-1RAAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresReduce alcohol intakeGLP-1RAsImpact of dipeptidyl peptidase-4 inhibitorReverse translational approachBaseline hazardous drinking
2024
A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program
Kember R, Rentsch C, Lynch J, Vujkovic M, Voight B, Justice A, Program M, Assimes T, Kranzler H. A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program. Alcohol Clinical And Experimental Research 2024, 48: 2256-2268. PMID: 39580711, PMCID: PMC11629435, DOI: 10.1111/acer.15445.Peer-Reviewed Original ResearchCoronary heart diseaseMR analysisMillion Veteran ProgramGenetic scoreAlcohol consumptionBody mass indexMendelian randomizationCardiometabolic diseasesVeteran ProgramAfrican AmericansAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresEuropean AmericansHispanic AmericansAssociation of alcohol consumptionMultivariable MR analysisAssociated with CHD riskMendelian randomization studiesRisk of cardiometabolic diseasesAssociated with alcohol consumptionCardiometabolic disease riskIncidence of coronary heart diseaseObservational studyNested case-control studyReduced risk of cardiometabolic diseasesMulti-ancestry population
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