2023
Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice
Kaye A, Kwan A, Pittenger C, Yu A, Yang J. Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice. Biological Psychiatry 2023, 93: s57. DOI: 10.1016/j.biopsych.2023.02.156.Peer-Reviewed Original ResearchMiceAdministration5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Woodburn S, Wehrle P, Sprouse J, Sherwood A, Kaye A, Pittenger C, Kwan A. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. Neuropsychopharmacology 2023, 48: 1257-1266. PMID: 37015972, PMCID: PMC10354037, DOI: 10.1038/s41386-023-01572-w.Peer-Reviewed Original ResearchConceptsMouse medial frontal cortexEarly phase clinical studiesDendritic spine densityHead-twitch responseDose-dependent increaseStructural neural plasticityMedial frontal cortexSpine densityClinical studiesFrontal cortexLong-term effectsDendritic spinesMental illnessNeural plasticitySpine formationPatient accessSubjective effectsNeural consequencesPotential therapeuticsSerotonergic psychedelicsAnxiety symptomsNeural mechanismsUltrasonic vocalizationsElevated ratesMiceCholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits
Rapanelli M, Wang W, Hurley E, Feltri M, Pittenger C, Frick L, Yan Z. Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits. Translational Psychiatry 2023, 13: 22. PMID: 36693858, PMCID: PMC9873627, DOI: 10.1038/s41398-023-02306-8.Peer-Reviewed Original ResearchConceptsBF cholinergic neuronsCholinergic neuronsBasal forebrainCognitive deficitsPrefrontal cortexBehavioral abnormalitiesASD-like behavioral abnormalitiesAutism spectrum disorderPrefrontal cortex projectionsSignificant cognitive impairmentChemogenetic stimulationCholinergic dysfunctionCholinergic projectionsChemogenetic inhibitionRisk factorsHealthy miceCortex projectionsPathogenic mechanismsSensory gatingCognitive impairmentNeuronsAbnormalitiesMiceDiminished activityFunction mutations
2014
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmphetamineAnimalsBrainChildDopamine AgonistsDopamine AntagonistsExploratory BehaviorFemaleHistidine DecarboxylaseHumansMaleMaze LearningMiceMice, KnockoutMiddle AgedMutationOxazinesRacloprideRadionuclide ImagingStereotyped BehaviorTime FactorsTourette SyndromeTryptophanYoung AdultConceptsTourette syndromeHA infusionKnockout miceD2/D3 receptor bindingDecarboxylase deficiencyDopamine D2 antagonist haloperidolCortico-basal ganglia circuitsStriatal DA levelsHDC knockout miceD3 receptor bindingImmediate early gene FosD2 antagonist haloperidolRare genetic causeBiosynthesis of histamineStriatal DARare causeBasal gangliaDA levelsAntagonist haloperidolGanglia circuitsPrepulse inhibitionMiceReceptor bindingGenetic causeHistidine decarboxylase
2008
O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice
Town T, Laouar Y, Pittenger C, Mori T, Szekely C, Tan J, Duman R, Flavell R. O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice. Alzheimer's & Dementia 2008, 4: t187-t188. DOI: 10.1016/j.jalz.2008.05.514.Peer-Reviewed Original Research