2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrial FibrillationCell MovementGene DeletionHeart AtriaHumansMacrophagesMiceMitral Valve InsufficiencyOsteopontinSingle-Cell Gene Expression AnalysisConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypass
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