2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2016
Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. Journal Of Thoracic And Cardiovascular Surgery 2016, 153: 924-932. PMID: 27938900, PMCID: PMC5715716, DOI: 10.1016/j.jtcvs.2016.10.066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationComputed Tomography AngiographyComputer-Aided DesignEndothelial CellsExtracellular MatrixMacrophagesModels, AnimalMyocytes, Smooth MuscleNanostructuresNanotechnologyNeointimaPhlebographyPrinting, Three-DimensionalProsthesis DesignSheep, DomesticTime FactorsTissue EngineeringVascular PatencyVascular RemodelingVena Cava, InferiorVenous PressureConceptsTissue-engineered vascular graftsSimilar mechanical propertiesComplex anatomical shapesMechanical propertiesVascular graftsNative inferior vena cavaBiodegradable scaffoldsComputer-aided designFeasible technologyNanofiber scaffoldsBiomechanical evaluationPrintingPressure gradientMandrelWall thicknessScaffoldsTechnologyAnatomic requirementsThicknessLayerDepositionEndothelialization
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