2023
Historical Accounts of Congenital Heart Surgery
Mavroudis C, Ong C, Vricella L, Cameron D. Historical Accounts of Congenital Heart Surgery. World Journal For Pediatric And Congenital Heart Surgery 2023, 14: 626-641. PMID: 37737603, DOI: 10.1177/21501351231186415.Peer-Reviewed Original ResearchRecruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmiasThe impact of a statewide payment reform on transcatheter aortic valve replacement (TAVR) utilization and readmissions
Yesantharao P, Etchill E, Zhou A, Ong C, Metkus T, Canner J, Alejo D, Aliu O, Czarny M, Hasan R, Resar J, Schena S. The impact of a statewide payment reform on transcatheter aortic valve replacement (TAVR) utilization and readmissions. Catheterization And Cardiovascular Interventions 2023, 101: 1193-1202. PMID: 37102376, DOI: 10.1002/ccd.30670.Peer-Reviewed Original ResearchPatient‐matched fetal simulator for fetoscopic myelomeningocele closure
Miller J, Chang R, Ong C, Miller G, Garcia J, Groves M, Rosner M, Baschat A. Patient‐matched fetal simulator for fetoscopic myelomeningocele closure. Ultrasound In Obstetrics And Gynecology 2023, 61: 270-272. PMID: 36178849, DOI: 10.1002/uog.26081.Peer-Reviewed Original Research
2022
Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry
Shou B, Ong C, Premraj L, Brown P, Tonna J, Dalton H, Kim B, Keller S, Whitman G, Cho S. Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry. The Journal Of Heart And Lung Transplantation 2022, 42: 503-511. PMID: 36435686, PMCID: PMC10050131, DOI: 10.1016/j.healun.2022.10.019.Peer-Reviewed Original ResearchConceptsAcute brain injuryExtracorporeal Life Support Organization registrySevere hyperoxiaIschemic strokeIntracranial hemorrhageECPR patientsArterial oxygenBrain injuryLarge international multicenter cohortMultivariable logistic regression analysisExtracorporeal cardiopulmonary resuscitation patientsInternational multicenter cohortSignificant risk factorsBlood gas dataBlood gas parametersCardiopulmonary resuscitation patientsLogistic regression analysisCarbon dioxide tensionHospital mortalityMild hypercarbiaMulticenter cohortReperfusion injuryMultivariable analysisResuscitation patientsRisk factorsCausal determinants of postoperative length of stay in cardiac surgery using causal graphical learning
Lee JJR, Srinivasan R, Ong CS, Alejo D, Schena S, Shpitser I, Sussman M, Whitman GJR, Malinsky D. Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: e446-e462. PMID: 36154975, PMCID: PMC9968823, DOI: 10.1016/j.jtcvs.2022.08.012.Peer-Reviewed Original ResearchConceptsAortic valve replacement surgeryPostoperative lengthCoronary artery bypassValve replacement surgeryElectronic health record dataHealth record dataArtery bypassReplacement surgeryRetrospective electronic health record dataMean postoperative lengthCardiac surgery patientsRecord dataClinical knowledgeIndirect causesPreoperative dialysisPostoperative complicationsSurgery patientsCardiac surgeryPatient managementStayClinical protocolsPatientsSurgeryOperating roomStatistical associationEarly Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery
Shou BL, Aravind P, Ong CS, Alejo D, Canner JK, Etchill EW, DiNatale J, Prokupets R, Esfandiary T, Lawton JS, Schena S. Early Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery. The Annals Of Thoracic Surgery 2022, 115: 232-239. PMID: 35952856, DOI: 10.1016/j.athoracsur.2022.07.037.Peer-Reviewed Original ResearchConceptsCardiac surgeryActive bleedingAdult cardiac surgery patientsSingle-institution retrospective reviewMultivariable logistic regression modelCardiac surgery patientsEarly surgical interventionRisk-adjusted analysisLogistic regression modelsEarly reexplorationEligible patientsPostoperative bleedingNonoperative managementSurgery patientsRetrospective reviewUnivariable analysisMorbidity rateSurgical interventionCommon siteMediastinal structuresReexplorationKruskal-Wallis testMortality rateBleedingPatient harmDeep Learning to Predict Mortality After Cardiothoracic Surgery Using Preoperative Chest Radiographs
Raghu VK, Moonsamy P, Sundt TM, Ong CS, Singh S, Cheng A, Hou M, Denning L, Gleason TG, Aguirre AD, Lu MT. Deep Learning to Predict Mortality After Cardiothoracic Surgery Using Preoperative Chest Radiographs. The Annals Of Thoracic Surgery 2022, 115: 257-264. PMID: 35609650, PMCID: PMC11373441, DOI: 10.1016/j.athoracsur.2022.04.056.Peer-Reviewed Original ResearchConceptsMassachusetts General HospitalPreoperative chest radiographSTS-PROMIndex procedureC-statisticChest radiographsTesting cohortPostoperative mortalityCardiac surgeryMortality riskPostoperative mortality riskSTS-PROM scoreRisk of mortalityGood calibrationMGH patientsWomen's HospitalGeneral HospitalCardiothoracic surgeryThoracic surgeonsSurgeryMortalityPatientsHospitalCohortPreoperative CXRArterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation
Shou BL, Ong CS, Zhou AL, Al-Kawaz MN, Etchill E, Giuliano K, Dong J, Bush E, Kim BS, Choi CW, Whitman G, Cho SM. Arterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2022, 68: 1501-1507. PMID: 35671442, PMCID: PMC9477972, DOI: 10.1097/mat.0000000000001699.Peer-Reviewed Original ResearchConceptsAcute brain injuryVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationPaCO 2Blood gas dataIntracranial hemorrhageBrain injuryMembrane oxygenationHypoxic-ischemic brain injuryArterial blood gas dataUnivariable logistic regression analysisArterial carbon dioxide tensionTertiary care centerVA-ECMO patientsArterial carbon dioxidePaCO 2 valuesLogistic regression analysisCarbon dioxide tensionPrevalence of ICHVA-ECMOAdult patientsCerebral edemaIschemic strokeCare centerBrain death
2021
Leveraging Machine Learning to Predict 30-Day Hospital Readmission After Cardiac Surgery
Sherman E, Alejo D, Wood-Doughty Z, Sussman M, Schena S, Ong CS, Etchill E, DiNatale J, Ahmidi N, Shpitser I, Whitman G. Leveraging Machine Learning to Predict 30-Day Hospital Readmission After Cardiac Surgery. The Annals Of Thoracic Surgery 2021, 114: 2173-2179. PMID: 34890575, DOI: 10.1016/j.athoracsur.2021.11.011.Peer-Reviewed Original ResearchConceptsElectronic medical record dataDays of dischargeMedical record dataHospital readmissionThoracic Surgeons Adult Cardiac Surgery DatabaseArt performanceAdult Cardiac Surgery DatabaseRecord dataCardiac Surgery DatabaseLength of stayRandom forest modelFlexible machineTest setMachinePreoperative comorbiditiesPostoperative complicationsAnalysis cohortCardiac surgeryPreoperative variablesSurgery DatabaseIntraoperative riskInpatient careReadmissionRisk scoreRehabilitation facilityNeuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support
Ong CS, Etchill E, Dong J, Shou BL, Shelley L, Giuliano K, Al-Kawaz M, Ritzl EK, Geocadin RG, Kim BS, Bush EL, Choi CW, Whitman GJR, Cho SM. Neuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 2104-2110.e1. PMID: 34865837, DOI: 10.1016/j.jtcvs.2021.09.063.Peer-Reviewed Original ResearchConceptsAcute brain injuryExtracorporeal membrane oxygenationMultivariable logistic regressionEra 2Neurological outcomeECMO patientsBrain injuryEra 1Pre-ECMO cardiac arrestUnderwent extracorporeal membrane oxygenationExtracorporeal membrane oxygenation supportLogistic regressionImproved neurological outcomeSerial neurological examinationsGood neurological outcomeMembrane oxygenation supportProportion of patientsTranscranial Doppler ultrasoundOxygenation supportMembrane oxygenationNeurological examinationCare consultationsCardiac arrestMultimodal neuromonitoringPatient outcomesLate onset atrial fibrillation in patients undergoing surgical aortic valve replacement
Ong CS, Reinertsen E, Moonsamy P, Young K, Song S, Axtell AL, Wolfe SB, Mohan N, Jassar AS, Aguirre AD, Sundt TM. Late onset atrial fibrillation in patients undergoing surgical aortic valve replacement. Journal Of Cardiac Surgery 2021, 37: 285-289. PMID: 34699088, DOI: 10.1111/jocs.16093.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLate atrial fibrillationOnset atrial fibrillationAortic valve replacementAtrial fibrillationValve replacementHigher preoperative creatinine levelLate-onset atrial fibrillationNew-onset atrial fibrillationSingle-institution cohort analysisPreoperative atrial fibrillationPreoperative creatinine levelAortic valve diseaseRisk of mortalityAF interventionsAF prophylaxisPerioperative episodesEmergent surgeryLate mortalityCardiac surgeryCreatinine levelsMedical therapyUnderwent proceduresValve diseaseProphylactic interventionsPrediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores
Ong CS, Reinertsen E, Sun H, Moonsamy P, Mohan N, Funamoto M, Kaneko T, Shekar PS, Schena S, Lawton JS, D'Alessandro DA, Westover MB, Aguirre AD, Sundt TM. Prediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 1449-1459.e15. PMID: 34607725, PMCID: PMC8918430, DOI: 10.1016/j.jtcvs.2021.09.010.Peer-Reviewed Original ResearchFast-Degrading Tissue-Engineered Vascular Grafts Lead to Increased Extracellular Matrix Cross-Linking Enzyme Expression
Fukunishi T, Ong CS, He YJ, Inoue T, Zhang H, Steppan J, Matsushita H, Johnson J, Santhanam L, Hibino N. Fast-Degrading Tissue-Engineered Vascular Grafts Lead to Increased Extracellular Matrix Cross-Linking Enzyme Expression. Tissue Engineering Part A 2021, 27: 1368-1375. PMID: 33599167, DOI: 10.1089/ten.tea.2020.0266.Peer-Reviewed Original ResearchConceptsVascular stiffnessNative aortaVascular graftsTissue-engineered vascular graftsLysyl oxidaseTissue transglutaminaseECM remodeling processRisk of infectionExtracellular matrixArterial pressureAneurysmal formationCardiovascular diseaseInterposition conduitsGraftSynthetic vascular graftsVascular neotissue formationLOX expressionCross-linking enzymeMonthsRemodeling processLack of endothelializationArterial prosthesesEnzyme expressionCompliance mismatchAortaRed blood cell storage duration and peri‐operative outcomes in paediatric cardiac surgery
Padiyath A, Lo BD, Ong CS, Goswami D, Steppan DA, Frank SM, Steppan J. Red blood cell storage duration and peri‐operative outcomes in paediatric cardiac surgery. Vox Sanguinis 2021, 116: 965-975. PMID: 33761164, DOI: 10.1111/vox.13098.Peer-Reviewed Original ResearchConceptsLength of stayRed blood cell (RBC) storage durationPediatric cardiac surgeryComposite morbidityRBC transfusion volumeCardiac surgeryOld bloodTransfusion volumePediatric cardiac surgery patientsMultivariable logistic regression modelFresh bloodRetrospective cohort studyCardiac surgery patientsPeri-operative outcomesRisk of morbidityRBC storage durationLonger durationRisk-adjusted modelsLogistic regression modelsCohort studySecondary outcomesSurgery patientsPediatric patientsPrimary outcomeClinical outcomesFactors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant
Funamoto M, Osho AA, Li SS, Moonsamy P, Mohan N, Ong CS, Melnitchouk S, Sundt TM, Astor TL, Villavicencio MA. Factors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant. The Annals Of Thoracic Surgery 2021, 112: 1797-1804. PMID: 33421391, DOI: 10.1016/j.athoracsur.2020.12.021.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateLung transplantationImproved survivalPreoperative glomerular filtration rateML/minNormal glomerular filtration rateLung transplant listingOrgan Sharing databaseLogistic regression analysisLung recipientsTransplant listingLung transplantAdult patientsPropensity matchingSharing databaseOutpatient statusUnited NetworkKaplan-MeierFiltration rateSuperior survivalPropensity score methodsPatientsTransplantationMultivariate analysisOutpatient recipients
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypassAssociation of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia
Crow JR, Nam L, Chasler JE, Ong CS, Dane KE, Kickler T, Lawton J, Streiff MB, Alejo D, Canner JK, Schena S. Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia. The Annals Of Thoracic Surgery 2020, 112: 32-37. PMID: 33217393, DOI: 10.1016/j.athoracsur.2020.09.033.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsAdult cardiac surgery patientsSurgery patientsUFH doseHeparin doseRetrospective case-control studyMultivariable conditional logistic regressionCardiopulmonary bypass durationHIT-positive patientsPrevalence of heparinUnfractionated heparin doseHeparin-Induced ThrombocytopeniaReceiver-operating characteristic curveCase-control studyConditional logistic regressionBypass durationIntravenous UFHUFH administrationUFH infusionSubcutaneous routeContinuous infusionMean agePatientsTotal doseLogistic regressionCommentary: Can Machines Predict Kidney Injury After Cardiac Surgery Better Than Humans?
Ong CS, Lawton JS. Commentary: Can Machines Predict Kidney Injury After Cardiac Surgery Better Than Humans? Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 748-749. PMID: 33171235, DOI: 10.1053/j.semtcvs.2020.10.017.Peer-Reviewed Original ResearchPulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return
Ong CS, D’Alessandro DA, Cameron DE, Melnitchouk S. Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 672-674. PMID: 32853065, DOI: 10.1177/2150135120918785.Peer-Reviewed Original ResearchConceptsPartial anomalous pulmonary venous returnAnomalous pulmonary venous returnPulmonary venous returnTube graftVenous returnLeft-sided partial anomalous pulmonary venous returnPolytetrafluoroethylene tube graftLeft atrial appendageTension-free anastomosisPulmonary veinsAtrial appendageVenoatrial connectionsVertical veinGraftVeinPatientsAnastomosis
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