2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2020
Different degradation rates of nanofiber vascular grafts in small and large animal models
Fukunishi T, Ong CS, Yesantharao P, Best CA, Yi T, Zhang H, Mattson G, Boktor J, Nelson K, Shinoka T, Breuer CK, Johnson J, Hibino N. Different degradation rates of nanofiber vascular grafts in small and large animal models. Journal Of Tissue Engineering And Regenerative Medicine 2020, 14: 203-214. PMID: 31756767, DOI: 10.1002/term.2977.Peer-Reviewed Original ResearchConceptsSmall animal modelsAnimal modelsLarge animal modelRat modelSheep modelVascular graftsGraft materialType of surgeryDuration of implantationExtracellular matrix depositionVenous circulationMonths postimplantationGraftAutologous tissueMature collagenMatrix depositionClinical translationElastin formationSurgery
2017
3D bioprinting using stem cells
Ong CS, Yesantharao P, Huang CY, Mattson G, Boktor J, Fukunishi T, Zhang H, Hibino N. 3D bioprinting using stem cells. Pediatric Research 2017, 83: 223-231. PMID: 28985202, DOI: 10.1038/pr.2017.252.Peer-Reviewed Original ResearchAdipose TissueAnimalsArtificial OrgansBiocompatible MaterialsBioprintingBone and BonesCardiovascular SystemHuman Umbilical Vein Endothelial CellsHumansInduced Pluripotent Stem CellsLasersLiverMesenchymal Stem CellsMiceMuscle, SkeletalNervous SystemPrinting, Three-DimensionalRegenerative MedicineSkinWound HealingRole of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Engineering Part A 2017, 24: 135-144. PMID: 28486019, PMCID: PMC5770093, DOI: 10.1089/ten.tea.2017.0044.Peer-Reviewed Original ResearchConceptsTissue-engineered vascular graftsElectrospun scaffoldsNeotissue formationNanofiber scaffoldsCardiovascular tissue engineeringUnseeded scaffoldsCell seeding efficiencyVascular graftsScaffold parametersTissue engineeringSeeding efficiencyPromising technologySeeded vascular graftsSeeded scaffoldsRational designElectron microscopyOptimal combinationPolyglycolic acidScaffoldsDesignConfluent endothelial monolayersSolutionEngineering
2016
Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model
Fukunishi T, Best CA, Sugiura T, Shoji T, Yi T, Udelsman B, Ohst D, Ong CS, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model. PLOS ONE 2016, 11: e0158555. PMID: 27467821, PMCID: PMC4965077, DOI: 10.1371/journal.pone.0158555.Peer-Reviewed Original ResearchConceptsMechanical propertiesPCL/chitosan scaffoldsNeotissue formationSmall diameter prosthetic graftsMechanical analysisVascular graftsElectrospun polycaprolactoneChitosan scaffoldsBiodegradable scaffoldsTEVGsArterial vascular graftsBlend nanofibersFast degradationPolycaprolactoneWall thicknessScaffoldsOriginal scaffoldMaterialsHost cell infiltrationPropertiesNanofibersMatrix constituentsNeotissuePatient's own cellsMacrophage infiltration
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