2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2021
Late onset atrial fibrillation in patients undergoing surgical aortic valve replacement
Ong CS, Reinertsen E, Moonsamy P, Young K, Song S, Axtell AL, Wolfe SB, Mohan N, Jassar AS, Aguirre AD, Sundt TM. Late onset atrial fibrillation in patients undergoing surgical aortic valve replacement. Journal Of Cardiac Surgery 2021, 37: 285-289. PMID: 34699088, DOI: 10.1111/jocs.16093.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLate atrial fibrillationOnset atrial fibrillationAortic valve replacementAtrial fibrillationValve replacementHigher preoperative creatinine levelLate-onset atrial fibrillationNew-onset atrial fibrillationSingle-institution cohort analysisPreoperative atrial fibrillationPreoperative creatinine levelAortic valve diseaseRisk of mortalityAF interventionsAF prophylaxisPerioperative episodesEmergent surgeryLate mortalityCardiac surgeryCreatinine levelsMedical therapyUnderwent proceduresValve diseaseProphylactic interventions
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