2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2022
Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning
Lee JJR, Srinivasan R, Ong CS, Alejo D, Schena S, Shpitser I, Sussman M, Whitman GJR, Malinsky D. Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: e446-e462. PMID: 36154975, PMCID: PMC9968823, DOI: 10.1016/j.jtcvs.2022.08.012.Peer-Reviewed Original ResearchConceptsAortic valve replacement surgeryPostoperative lengthCoronary artery bypassValve replacement surgeryElectronic health record dataHealth record dataArtery bypassReplacement surgeryRetrospective electronic health record dataMean postoperative lengthCardiac surgery patientsRecord dataClinical knowledgeIndirect causesPreoperative dialysisPostoperative complicationsSurgery patientsCardiac surgeryPatient managementStayClinical protocolsPatientsSurgeryOperating roomStatistical associationResting Energy Expenditure of Patients on Venovenous Extracorporeal Membrane Oxygenation for Adult Respiratory Distress Syndrome: A Pilot Study
Ong CS, Brown P, Shou BL, Wilcox C, Cho SM, Mendez-Tellez PA, Kim BS, Whitman GJR, Whitman G, Cho S, Acton M, Rando H, Alejo D, Calligy K, Anderson S, Sussman M, Wilcox C. Resting Energy Expenditure of Patients on Venovenous Extracorporeal Membrane Oxygenation for Adult Respiratory Distress Syndrome: A Pilot Study. Critical Care Explorations 2022, 4: e0730. PMID: 35923588, PMCID: PMC9296180, DOI: 10.1097/cce.0000000000000730.Peer-Reviewed Original ResearchAcute respiratory distress syndrome patientsAdult respiratory distress syndromeRespiratory distress syndrome patientsVenovenous extracorporeal membrane oxygenationAdult ARDS patientsExtracorporeal membrane oxygenationML/Respiratory distress syndromeRetrospective observational studyEnergy expenditureCarbon dioxide eliminationPatient's paralysisVenovenous ECMOECMO flowARDS patientsDistress syndromePulmonary functionMembrane oxygenationMean REEBlood gasesObservational studySyndrome patientsTidal volumePatientsBody weightDeep Learning to Predict Mortality After Cardiothoracic Surgery Using Preoperative Chest Radiographs
Raghu VK, Moonsamy P, Sundt TM, Ong CS, Singh S, Cheng A, Hou M, Denning L, Gleason TG, Aguirre AD, Lu MT. Deep Learning to Predict Mortality After Cardiothoracic Surgery Using Preoperative Chest Radiographs. The Annals Of Thoracic Surgery 2022, 115: 257-264. PMID: 35609650, PMCID: PMC11373441, DOI: 10.1016/j.athoracsur.2022.04.056.Peer-Reviewed Original ResearchConceptsMassachusetts General HospitalPreoperative chest radiographSTS-PROMIndex procedureC-statisticChest radiographsTesting cohortPostoperative mortalityCardiac surgeryMortality riskPostoperative mortality riskSTS-PROM scoreRisk of mortalityGood calibrationMGH patientsWomen's HospitalGeneral HospitalCardiothoracic surgeryThoracic surgeonsSurgeryMortalityPatientsHospitalCohortPreoperative CXR
2021
Factors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant
Funamoto M, Osho AA, Li SS, Moonsamy P, Mohan N, Ong CS, Melnitchouk S, Sundt TM, Astor TL, Villavicencio MA. Factors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant. The Annals Of Thoracic Surgery 2021, 112: 1797-1804. PMID: 33421391, DOI: 10.1016/j.athoracsur.2020.12.021.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateLung transplantationImproved survivalPreoperative glomerular filtration rateML/minNormal glomerular filtration rateLung transplant listingOrgan Sharing databaseLogistic regression analysisLung recipientsTransplant listingLung transplantAdult patientsPropensity matchingSharing databaseOutpatient statusUnited NetworkKaplan-MeierFiltration rateSuperior survivalPropensity score methodsPatientsTransplantationMultivariate analysisOutpatient recipients
2020
Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia
Crow JR, Nam L, Chasler JE, Ong CS, Dane KE, Kickler T, Lawton J, Streiff MB, Alejo D, Canner JK, Schena S. Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia. The Annals Of Thoracic Surgery 2020, 112: 32-37. PMID: 33217393, DOI: 10.1016/j.athoracsur.2020.09.033.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsAdult cardiac surgery patientsSurgery patientsUFH doseHeparin doseRetrospective case-control studyMultivariable conditional logistic regressionCardiopulmonary bypass durationHIT-positive patientsPrevalence of heparinUnfractionated heparin doseHeparin-Induced ThrombocytopeniaReceiver-operating characteristic curveCase-control studyConditional logistic regressionBypass durationIntravenous UFHUFH administrationUFH infusionSubcutaneous routeContinuous infusionMean agePatientsTotal doseLogistic regressionPulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return
Ong CS, D’Alessandro DA, Cameron DE, Melnitchouk S. Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 672-674. PMID: 32853065, DOI: 10.1177/2150135120918785.Peer-Reviewed Original ResearchConceptsPartial anomalous pulmonary venous returnAnomalous pulmonary venous returnPulmonary venous returnTube graftVenous returnLeft-sided partial anomalous pulmonary venous returnPolytetrafluoroethylene tube graftLeft atrial appendageTension-free anastomosisPulmonary veinsAtrial appendageVenoatrial connectionsVertical veinGraftVeinPatientsAnastomosisNutrition Support After Cardiac Surgery: Lessons Learned From a Prospective Study
Ong CS, Yesantharao P, Brown PM, Canner JK, Brown TA, Sussman MS, Whitman GJR. Nutrition Support After Cardiac Surgery: Lessons Learned From a Prospective Study. Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 109-115. PMID: 32610197, DOI: 10.1053/j.semtcvs.2020.06.043.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsNutrition supportDaily caloric needsSurgery patientsCardiac surgeryCaloric needsPostoperative nutrition supportPercent of patientsMultivariable logistic regressionRisk of diarrheaPN supplementationPostpyloric feedsPostpyloric routeSemielemental formulaEnteral feedingParenteral nutritionCommon indicationMechanical ventilationProspective studySingle institutionTF volumeCommon reasonPatientsLogistic regressionMorbidityThe Strongest Risk Factor for Operative Mortality in Acute Type A Aortic Dissection is Acidosis: Validation of Risk Model
Ong CS, Nam L, Yesantharao P, Dong J, Canner JK, Teuben RJ, Zhou X, Young A, Suarez-Pierre A, Pasque MK, Lawton JS. The Strongest Risk Factor for Operative Mortality in Acute Type A Aortic Dissection is Acidosis: Validation of Risk Model. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 674-680. PMID: 32105786, DOI: 10.1053/j.semtcvs.2020.02.023.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAcidosisAcute DiseaseAdolescentAdultAgedAged, 80 and overAlgorithmsAortic AneurysmAortic DissectionDecision Support TechniquesFemaleHemodynamicsHospital MortalityHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTreatment OutcomeVascular Surgical ProceduresYoung AdultConceptsHigh operative mortalityOperative mortalityMultivariable logistic regressionSevere acidosisATAAD repairOrgan malperfusionAortic dissectionBase deficitRisk factorsAcute Type A Aortic DissectionType A Aortic DissectionLogistic regressionA Aortic DissectionPresence of diabetesRetrospective chart reviewMultiple risk factorsAbdominal malperfusionNadir pHAcute typeChart reviewTreatment algorithmAdvanced ageMalperfusionPatientsAcidosisVasoactive and Inotropic Support, Tube Feeding, and Ischemic Gut Complications After Cardiac Surgery
Ong CS, Brown PM, Yesantharao P, Zhou X, Young A, Canner JK, Quinlan M, Brown EF, Sussman MS, Whitman GJR. Vasoactive and Inotropic Support, Tube Feeding, and Ischemic Gut Complications After Cardiac Surgery. Journal Of Parenteral And Enteral Nutrition 2020, 44: 1461-1467. PMID: 32010992, DOI: 10.1002/jpen.1769.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsTube feedsGut complicationsInotropic supportIntra-aortic balloon pumpElemental formula usePressor supportGastric routeBalloon pumpCardiac surgeryTube feedingTF administrationAcute embolusSingle institutionPatientsFormula useComplicationsHighest VIsDecreased amountDaysInotropicEmboliSurgeryMortality
2019
ROLE OF GEOGRAPHIC LOCATION AND SOCIOECONOMIC STATUS IN THE OUTCOME OF PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR): A STATE-WIDE ANALYSIS
Ong C, Canner J, Nam L, Teuben R, Han J, Schena S. ROLE OF GEOGRAPHIC LOCATION AND SOCIOECONOMIC STATUS IN THE OUTCOME OF PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR): A STATE-WIDE ANALYSIS. Journal Of The American College Of Cardiology 2019, 73: 1104. DOI: 10.1016/s0735-1097(19)31711-5.Peer-Reviewed Original ResearchTrends and Updates on Cardiopulmonary Bypass Setup in Pediatric Cardiac Surgery
Medikonda R, Ong CS, Wadia R, Goswami D, Schwartz J, Wolff L, Hibino N, Vricella L, Nyhan D, Barodka V, Steppan J. Trends and Updates on Cardiopulmonary Bypass Setup in Pediatric Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 33: 2804-2813. PMID: 30738750, DOI: 10.1053/j.jvca.2019.01.025.Peer-Reviewed Original ResearchConceptsCardiac surgeryCardiopulmonary bypassPediatric cardiac surgery outcomesPediatric cardiac surgeryEvidence-based guidelinesCardiac surgery outcomesCardiopulmonary bypass managementUniform evidence-based guidelinesExtracorporeal circuit componentsInconsistent study resultsPediatric patientsClinical outcomesSurgery outcomesCardiopulmonary bypass (CPB) setupBypass managementPerfusion strategyPerfusion practiceSurgeryBypassCurrent literatureOutcomesConsiderable variabilityPatientsStudy resultsCrystalloids
2017
Neuromuscular Disease Cardiac Manifestations and Sudden Death Risk
Limipitikul W, Ong CS, Tomaselli GF. Neuromuscular Disease Cardiac Manifestations and Sudden Death Risk. Cardiac Electrophysiology Clinics 2017, 9: 731-747. PMID: 29173414, DOI: 10.1016/j.ccep.2017.07.013.Peer-Reviewed Original ResearchConceptsNeuromuscular diseaseSudden death riskPresence of bradycardiaConduction system diseaseCardiac conduction systemCardiovascular complicationsCardiac manifestationsPreemptive treatmentHeart blockSignificant morbidityVentricular arrhythmiasPermanent pacemakerDeath riskSystem diseasesCardiac arrhythmiasConduction systemDiseasePatientsArrhythmiasRiskBradycardiaMorbidityComplicationsTachyarrhythmiasMortalityTriple Cultures Increase the Diagnostic Sensitivity of Mycobacterial Tuberculosis Empyema
Ong K, Rajapaksha K, Ong CS, Fazuludeen AA, Ahmed ADB. Triple Cultures Increase the Diagnostic Sensitivity of Mycobacterial Tuberculosis Empyema. Tuberculosis Research And Treatment 2017, 2017: 4362804. PMID: 29057121, PMCID: PMC5605862, DOI: 10.1155/2017/4362804.Peer-Reviewed Original ResearchPleural fluidDiagnostic yieldDiagnostic approachRetrospective cohort studyCommon surgical complicationExcellent diagnostic yieldAppropriate diagnostic approachPleural debridementCohort studyPosterolateral thoracotomySurgical complicationsClinical featuresSurgical managementGranulomatous inflammationSurgical interventionSurgical outcomesSingle institutionHistological examinationAir leakPleural tissueEmpyemaPatientsSurgeryDiagnostic sensitivityTissue cultureThe use of 3D printing in cardiac surgery
Ong CS, Hibino N. The use of 3D printing in cardiac surgery. Journal Of Thoracic Disease 2017, 9: 2301-2302. PMID: 28932530, PMCID: PMC5594159, DOI: 10.21037/jtd.2017.07.73.Peer-Reviewed Original ResearchKommerell's diverticulumAortic archAberrant left subclavian arteryRight-sided aortic archPostoperative computed tomography scansFrozen elephant trunkLeft subclavian arteryComputed tomography scanSubclavian arteryUneventful recoveryCardiac surgerySurgical repairOperative timeCase reportTomography scanElephant trunkSurgical guideGraft shapePatientsSurgeryDiverticulumArchPatencyArteryAortaLeft heart decompression in patients supported with extracorporeal membrane oxygenation for cardiac disease
Ong CS, Hibino N. Left heart decompression in patients supported with extracorporeal membrane oxygenation for cardiac disease. Advances In Interventional Cardiology 2017, 13: 1-2. PMID: 28344610, PMCID: PMC5364275, DOI: 10.5114/aic.2017.66179.Peer-Reviewed Original Research
2016
Cesarean section in the setting of severe pulmonary hypertension requiring extracorporeal life support
Hara R, Hara S, Ong CS, Schwartz G, Sciortino C, Hibino N. Cesarean section in the setting of severe pulmonary hypertension requiring extracorporeal life support. General Thoracic And Cardiovascular Surgery 2016, 65: 532-534. PMID: 27888446, DOI: 10.1007/s11748-016-0729-x.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationFixed pulmonary hypertensionPulmonary hypertensionCesarean sectionVeno-arterial extracorporeal membrane oxygenationInitiation of ECMOHigh maternal mortality rateSudden hemodynamic collapseSevere pulmonary hypertensionExtracorporeal life supportWeeks of gestationMaternal mortality rateCardiogenic shockChest painHemodynamic collapseMembrane oxygenationClinical evaluationFemoral linesRapid cannulationMortality rateHypertensionLife supportPatientsDeliveryDyspneaSingle-Stage Total Arch Replacement Including Resection of Kommerell Diverticulum in a Patient With Loeys-Dietz Syndrome
Ong CS, Kasai Y, Fukushima S, Hibino N, Magruder T, Suarez-Pierre A, Cameron D, Vricella L. Single-Stage Total Arch Replacement Including Resection of Kommerell Diverticulum in a Patient With Loeys-Dietz Syndrome. World Journal For Pediatric And Congenital Heart Surgery 2016, 7: 651-654. PMID: 27521346, DOI: 10.1177/2150135116656979.Peer-Reviewed Original ResearchConceptsLoeys-Dietz syndromeKommerell's diverticulumTotal aortic arch replacementGenetic connective tissue disorderAortic arch replacementAortic aneurysmal diseaseConnective tissue disordersArch replacementAortic diverticulumPediatric patientsMedian sternotomyAneurysmal diseaseSurgical techniqueTissue disordersDiverticulumResectionPatientsSyndromeSubject of debateSternotomySurgeryDisease
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