2023
Recruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias
2019
Cardiac regeneration using human‐induced pluripotent stem cell‐derived biomaterial‐free 3D‐bioprinted cardiac patch in vivo
Yeung E, Fukunishi T, Bai Y, Bedja D, Pitaktong I, Mattson G, Jeyaram A, Lui C, Ong CS, Inoue T, Matsushita H, Abdollahi S, Jay SM, Hibino N. Cardiac regeneration using human‐induced pluripotent stem cell‐derived biomaterial‐free 3D‐bioprinted cardiac patch in vivo. Journal Of Tissue Engineering And Regenerative Medicine 2019, 13: 2031-2039. PMID: 31408915, PMCID: PMC7254497, DOI: 10.1002/term.2954.Peer-Reviewed Original ResearchConceptsControl groupHeart failureCardiac functionPatch groupCardiac tissueCause of deathRat myocardial infarction modelHuman-induced pluripotent stem cell-derived cardiomyocytesMyocardial infarction modelScar tissue formationPluripotent stem cell-derived cardiomyocytesTrend of improvementStem cell-derived cardiomyocytesVivo regenerative potentialCell-derived cardiomyocytesInfarcted areaSurvival rateInfarction modelInfarcted tissueScar areaEndothelial cellsCardiac regenerationCardiac patchesRegenerative potentialEchocardiographyPulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device
Muslem R, Ong C, Tomashitis B, Schultz J, Ramu B, Craig M, Van Bakel A, Gilotra N, Sharma K, Hsu S, Whitman G, Leary P, Cogswell R, Lozonschi L, Houston B, Zijlstra F, Caliskan K, Bogers A, Tedford R. Pulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device. Circulation Heart Failure 2019, 12: e005923. PMID: 31401840, DOI: 10.1161/circheartfailure.119.005923.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedCardiac CatheterizationEchocardiographyElasticityFemaleHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedPostoperative ComplicationsPulmonary ArteryRegistriesRetrospective StudiesStroke VolumeSurvival RateUnited StatesVascular ResistanceVentricular Function, RightConceptsSevere acute right heart failureAcute right heart failureRight heart failureSystolic pulmonary artery pressurePulmonary artery pressureVentricular assist device implantationPulmonary arterial elastanceAssist device implantationRight atrial pressureArtery pressureVentricular assist deviceAtrial pressureHeart failureArterial elastanceDevice implantationAssist deviceSevere right heart failureIndependent hazard ratioStrongest hemodynamic predictorRight heart catheterizationLarge academic centerDevice survival ratesPreimplant variablesCause mortalityHeart catheterizationA Net Mold-Based Method of Biomaterial-Free Three-Dimensional Cardiac Tissue Creation
Yang B, Lui C, Yeung E, Matsushita H, Jeyaram A, Pitaktong I, Inoue T, Mohamed Z, Ong CS, DiSilvestre D, Jay SM, Tung L, Tomaselli G, Ma C, Hibino N. A Net Mold-Based Method of Biomaterial-Free Three-Dimensional Cardiac Tissue Creation. Tissue Engineering Part C Methods 2019, 25: 243-252. PMID: 30913987, DOI: 10.1089/ten.tec.2019.0003.Peer-Reviewed Original ResearchConceptsCardiac tissueSignificant public health burdenSmaller scar areaPublic health burdenAlternative treatment strategiesCollagen I expressionHeart failureLeft anteriorEjection fractionGel patchHealth burdenRat modelTreatment strategiesI expressionSimple reproducible methodEndothelial cellsScar areaThree-dimensional cardiac tissueCell viabilityTissueReproducible methodIrreversible lossCells
2017
*Bilateral Arteriovenous Shunts as a Method for Evaluating Tissue-Engineered Vascular Grafts in Large Animal Models
Ong CS, Fukunishi T, Liu RH, Nelson K, Zhang H, Wieczorek E, Palmieri M, Ueyama Y, Ferris E, Geist GE, Youngblood B, Johnson J, Hibino N. *Bilateral Arteriovenous Shunts as a Method for Evaluating Tissue-Engineered Vascular Grafts in Large Animal Models. Tissue Engineering Part C Methods 2017, 23: 728-735. PMID: 28741438, PMCID: PMC6436030, DOI: 10.1089/ten.tec.2017.0217.Peer-Reviewed Original ResearchConceptsLarge animal modelAnimal modelsAcute heart failureHypoxic brain injuryTissue-engineered vascular graftsNon-invasive evaluationHuman clinical trialsVascular graftsArterial pressureGraft patencyHeart failureGraft flowGraft diameterPreclinical dataBrain injuryClinical trialsContralateral sideUltrasound guidancePathological analysisArteriovenous shuntsPreclinical evaluationNeedle punctureInter-subject variabilityImplantation modelGraftHeart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Gilotra NA, Bhonsale A, James CA, Te Riele ASJ, Murray B, Tichnell C, Sawant A, Ong CS, Judge DP, Russell SD, Calkins H, Tedford RJ. Heart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Circulation Heart Failure 2017, 10: e003819. PMID: 28874384, DOI: 10.1161/circheartfailure.116.003819.Peer-Reviewed Original ResearchConceptsPrecordial T-wave inversionTask Force criteriaT-wave inversionHF signsExertional dyspneaLV dysfunctionVolume overloadClinical HFVentricular cardiomyopathy/dysplasiaPredictors of HFSymptomatic LV dysfunctionHeart failure prevalenceForce criteriaARVC/DARVC/D.ARVC/D diagnosisHeart transplantationHF symptomsRV involvementHeart failureStudy cohortFemale sexHF onsetHigher oddsStudy follow(1292) Prognostic Relevance of INTERMACS Defined Right Heart Failure After Left Ventricular Assists Device Implantation
Muslem R, Ong C, Gilotra N, Sharma K, Houston B, Zehr K, Duquaine D, Whitman G, Caliskan K, Russell S, Tedford R. (1292) Prognostic Relevance of INTERMACS Defined Right Heart Failure After Left Ventricular Assists Device Implantation. The Journal Of Heart And Lung Transplantation 2017, 36: s420-s421. DOI: 10.1016/j.healun.2017.01.1204.Peer-Reviewed Original Research
2016
Constrictive Pericarditis Following Correction of Partial Anomalous Pulmonary Venous Drainage
Ong CS, Shankar S, Yip JWL, Tay ELW, Teo LLS, Quek SC. Constrictive Pericarditis Following Correction of Partial Anomalous Pulmonary Venous Drainage. World Journal For Pediatric And Congenital Heart Surgery 2016, 8: 540-542. PMID: 27647341, DOI: 10.1177/2150135116652116.Peer-Reviewed Original ResearchConceptsConstrictive pericarditisPartial anomalous pulmonary venous drainagePartial anomalous pulmonary venous connectionPersistent right heart failureAnomalous pulmonary venous connectionAnomalous pulmonary venous drainagePulmonary valve replacementRight heart failurePulmonary venous connectionPulmonary venous drainageRepair of tetralogyFailure of surgeryCongenital cardiac surgeryMagnetic resonance imagingRadical pericardiectomyResidual complicationsValve replacementVenous connectionCardiac surgeryHeart failureCardiac failureMedical managementVenous drainageBetter outcomesResonance imaging
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