2023
Impact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery
Shou B, Zhou A, Ong C, Alejo D, DiNatale J, Larson E, Lawton J, Schena S. Impact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 873-884.e4. PMID: 37839660, DOI: 10.1016/j.jtcvs.2023.10.011.Peer-Reviewed Original ResearchIntraoperative blood product transfusionIntensive care unit arrivalCore body temperatureBlood product transfusionCardiac surgeryPerioperative bleedingProduct transfusionCrystalloid administrationFluid administrationUnit arrivalRisk factorsAdult cardiac surgery patientsGreater postoperative morbidityIntraoperative blood productsSevere postoperative bleedingCardiac surgery patientsBlood product administrationIntravenous fluid administrationLower core body temperatureSuch risk factorsElectronic medical recordsPersistent hypothermiaPostoperative bleedingPostoperative morbidityIntraoperative fluid
2022
Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning
Lee JJR, Srinivasan R, Ong CS, Alejo D, Schena S, Shpitser I, Sussman M, Whitman GJR, Malinsky D. Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: e446-e462. PMID: 36154975, PMCID: PMC9968823, DOI: 10.1016/j.jtcvs.2022.08.012.Peer-Reviewed Original ResearchConceptsAortic valve replacement surgeryPostoperative lengthCoronary artery bypassValve replacement surgeryElectronic health record dataHealth record dataArtery bypassReplacement surgeryRetrospective electronic health record dataMean postoperative lengthCardiac surgery patientsRecord dataClinical knowledgeIndirect causesPreoperative dialysisPostoperative complicationsSurgery patientsCardiac surgeryPatient managementStayClinical protocolsPatientsSurgeryOperating roomStatistical associationEarly Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery
Shou BL, Aravind P, Ong CS, Alejo D, Canner JK, Etchill EW, DiNatale J, Prokupets R, Esfandiary T, Lawton JS, Schena S. Early Reexploration for Bleeding Is Associated With Improved Outcome in Cardiac Surgery. The Annals Of Thoracic Surgery 2022, 115: 232-239. PMID: 35952856, DOI: 10.1016/j.athoracsur.2022.07.037.Peer-Reviewed Original ResearchConceptsCardiac surgeryActive bleedingAdult cardiac surgery patientsSingle-institution retrospective reviewMultivariable logistic regression modelCardiac surgery patientsEarly surgical interventionRisk-adjusted analysisLogistic regression modelsEarly reexplorationEligible patientsPostoperative bleedingNonoperative managementSurgery patientsRetrospective reviewUnivariable analysisMorbidity rateSurgical interventionCommon siteMediastinal structuresReexplorationKruskal-Wallis testMortality rateBleedingPatient harm
2021
Red blood cell storage duration and peri‐operative outcomes in paediatric cardiac surgery
Padiyath A, Lo BD, Ong CS, Goswami D, Steppan DA, Frank SM, Steppan J. Red blood cell storage duration and peri‐operative outcomes in paediatric cardiac surgery. Vox Sanguinis 2021, 116: 965-975. PMID: 33761164, DOI: 10.1111/vox.13098.Peer-Reviewed Original ResearchConceptsLength of stayRed blood cell (RBC) storage durationPediatric cardiac surgeryComposite morbidityRBC transfusion volumeCardiac surgeryOld bloodTransfusion volumePediatric cardiac surgery patientsMultivariable logistic regression modelFresh bloodRetrospective cohort studyCardiac surgery patientsPeri-operative outcomesRisk of morbidityRBC storage durationLonger durationRisk-adjusted modelsLogistic regression modelsCohort studySecondary outcomesSurgery patientsPediatric patientsPrimary outcomeClinical outcomes
2020
Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia
Crow JR, Nam L, Chasler JE, Ong CS, Dane KE, Kickler T, Lawton J, Streiff MB, Alejo D, Canner JK, Schena S. Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia. The Annals Of Thoracic Surgery 2020, 112: 32-37. PMID: 33217393, DOI: 10.1016/j.athoracsur.2020.09.033.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsAdult cardiac surgery patientsSurgery patientsUFH doseHeparin doseRetrospective case-control studyMultivariable conditional logistic regressionCardiopulmonary bypass durationHIT-positive patientsPrevalence of heparinUnfractionated heparin doseHeparin-Induced ThrombocytopeniaReceiver-operating characteristic curveCase-control studyConditional logistic regressionBypass durationIntravenous UFHUFH administrationUFH infusionSubcutaneous routeContinuous infusionMean agePatientsTotal doseLogistic regressionNutrition Support After Cardiac Surgery: Lessons Learned From a Prospective Study
Ong CS, Yesantharao P, Brown PM, Canner JK, Brown TA, Sussman MS, Whitman GJR. Nutrition Support After Cardiac Surgery: Lessons Learned From a Prospective Study. Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 109-115. PMID: 32610197, DOI: 10.1053/j.semtcvs.2020.06.043.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsNutrition supportDaily caloric needsSurgery patientsCardiac surgeryCaloric needsPostoperative nutrition supportPercent of patientsMultivariable logistic regressionRisk of diarrheaPN supplementationPostpyloric feedsPostpyloric routeSemielemental formulaEnteral feedingParenteral nutritionCommon indicationMechanical ventilationProspective studySingle institutionTF volumeCommon reasonPatientsLogistic regressionMorbidityVasoactive and Inotropic Support, Tube Feeding, and Ischemic Gut Complications After Cardiac Surgery
Ong CS, Brown PM, Yesantharao P, Zhou X, Young A, Canner JK, Quinlan M, Brown EF, Sussman MS, Whitman GJR. Vasoactive and Inotropic Support, Tube Feeding, and Ischemic Gut Complications After Cardiac Surgery. Journal Of Parenteral And Enteral Nutrition 2020, 44: 1461-1467. PMID: 32010992, DOI: 10.1002/jpen.1769.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsTube feedsGut complicationsInotropic supportIntra-aortic balloon pumpElemental formula usePressor supportGastric routeBalloon pumpCardiac surgeryTube feedingTF administrationAcute embolusSingle institutionPatientsFormula useComplicationsHighest VIsDecreased amountDaysInotropicEmboliSurgeryMortality
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