Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation
Chen CY, Chen HF, Gi SJ, Chi TH, Cheng CK, Hsu CF, Ma YS, Wei YH, Liu CS, Hsieh M. Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation. Mitochondrion 2011, 11: 739-749. PMID: 21679777, DOI: 10.1016/j.mito.2011.05.014.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisAutophagyAutophagy-Related Protein 12Autophagy-Related Protein 5Caspase 3Cells, CulturedDNA, MitochondrialDown-RegulationEnzyme ActivationHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHumansMERRF SyndromeMicrotubule-Associated ProteinsMolecular ChaperonesPoint MutationProteolysisSmall Ubiquitin-Related Modifier ProteinsStress, PhysiologicalConceptsMERRF cybridsA8344G mutationAutophagic pathwayMitochondrial DNA mutationsMutant cybridsDNA mutationsMERRF syndromeNormal heat shock responseNormal cytoplasmic distributionWild-type HSP27G mutationHeat shock responseA8344G mitochondrial DNA mutationElectron transport chainMERRF cellsCybrid cellsHeat shock protein 27Accumulation of HSP27Impairs assemblyHeat shock protein 27 expressionShock protein 27CybridsStaurosporine treatmentWild typeCytoplasmic distribution