The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged‐red fibers A8344G mtDNA mutation
Chen H, Chen C, Lin T, Huang Z, Chi T, Ma Y, Wu S, Wei Y, Hsieh M. The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged‐red fibers A8344G mtDNA mutation. The FEBS Journal 2012, 279: 2987-3001. PMID: 22742457, DOI: 10.1111/j.1742-4658.2012.08678.x.Peer-Reviewed Original ResearchConceptsMutant cybridsA8344G mutationHeat shock protein 27Shock protein 27Mitochondrial diseaseMERRF syndromeWild-type cybridsMitochondrial protein synthesisHeat shock stressProtein 27Phosphorylated heat shock protein 27P-HSP27Mitochondrial DNA mutationsG mutationRagged-red fibers (MERRF) syndromeHsp27 mutantsNormal kinaseSpecific serineCytoplasmic hybridsMaternal lineagesSteady-state levelsNormal phosphorylationApoptotic stressCybridsMtDNA mutations