Featured Publications
Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease
Luna P, Harris K, Castro-Dominguez Y, Algara M, Severiche-Mena C, Smolderen KG, Mena-Hurtado C. Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease. Journal Of Vascular Surgery 2022, 77: 216-224.e15. PMID: 36037965, DOI: 10.1016/j.jvs.2022.08.021.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseLower extremity peripheral artery diseaseNon-Hispanic whitesEmergency departmentPAD careArtery diseaseRisk factorsSevere peripheral artery diseaseChronic limb-threatening ischemiaRisk profileNational Inpatient Sample dataCardiovascular risk factorsLimb-threatening ischemiaPatients' sociodemographic characteristicsWorse clinical outcomesMultivariable logistic regressionAssociation of ethnicityLength of stayHealth care consumptionHealth care coveragePAD hospitalizationsPrior amputationEndovascular revascularizationED admissionRenal failureGuideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation dataLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleInter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative
Smolderen K, Romain G, Scierka L, Cleman J, Rahman M, Siddiqui W, Lau F, Mao J, Akhlaghi N, Higaki A, Fowler X, Carroll M, Telma K, Alvermann T, Baribeau V, Goodney P, Mena-Hurtado C. Inter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative. JACC Cardiovascular Interventions 2024, 17: 622-631. PMID: 38479964, DOI: 10.1016/j.jcin.2024.01.003.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record reviewAmputation dataPeripheral arterial diseaseInterrater reliabilityVQI registryAcademic health systemTrained data collectorsNational quality registryInter-rater reliabilityEvaluate interrater reliabilityNational reporting systemHealth recordsQuality registryHealth systemCurrent Procedural Terminology codesInter-raterVascular Quality Initiative registryVascular Quality InitiativeProcedural Terminology codesNational Vascular Quality InitiativeRegistryQuality InitiativeAmputationSpearman's rAssociation Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Samaan Z, Decker C, Collins T, Lazar R, Itoga N, Mena-Hurtado C, Research O. Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 1511-1528. PMID: 37781785, DOI: 10.1161/cir.0000000000001178.Peer-Reviewed Original ResearchConceptsPsychological interventionsPeripheral artery diseaseMental healthStress reduction interventionsSymptomatic peripheral artery diseaseComorbid mental health conditionsMental health concernsRole of painMental health conditionsMental health burdenPAD careCognitive declineBehavioral health needsArtery diseaseCognitive dysfunctionPsychotropic interventionScientific statementPAD treatmentBehavior changeUse of opioidsAmerican Heart AssociationUse of benzodiazepinesChronic disease managementHealth behaviorsFragmentation of care
2025
Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial. Journal Of Vascular Surgery 2025, 81: 945-956.e3. PMID: 39846933, DOI: 10.1016/j.jvs.2024.12.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChronic Limb-Threatening IschemiaEndovascular ProceduresFemaleGlomerular Filtration RateHumansIschemiaKidneyLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaChronic kidney diseaseDialysis-dependent patientsBEST-CLIChronic kidney disease stagePrimary trial outcomeRisk of amputationAssociated with lower mortalityEndovascular therapyAll-cause mortalityHigh risk of poor outcomesRisk of poor outcomesEndovascular revascularizationKidney diseaseBEST-CLI trialOutcomes of lower extremity revascularizationAssociated with better survivalMultivariate Cox regression analysisBest Surgical TherapyIncreased reintervention rateStage 4 CKD patientsRisk of reinterventionGroup C patientsAdverse limb eventsChronic kidney disease severityDefining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting
Kluger J, Romain G, Mena‐Hurtado C, Grubman S, Pajarillo C, Cleman J, Scierka L, Smolderen K. Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting. Catheterization And Cardiovascular Interventions 2025, 105: 927-937. PMID: 39789704, DOI: 10.1002/ccd.31410.Peer-Reviewed Original ResearchConceptsMinimal clinically important differenceHealth status changesHealth statusSF-36Visual analog scaleEQ-5DDistribution-based MCIDPhysical component scoreCarotid artery stentingDisease-specific instrumentHealth status improvementTransfemoral carotid artery stentingSymptom statusClinically important differenceTF-CASStatus changesGeneric instrumentsArtery stentingRegistry dataComponent scoresImportant differencePatients no changeStatus improvementAsymptomatic carotid stenosisHealth
2024
Chronic Venous Insufficiency and Management
Attaran R, Babapour G, Mena-Hurtado C, Ochoa Chaar C. Chronic Venous Insufficiency and Management. Interventional Cardiology Clinics 2024, 14: 283-296. PMID: 40049854, DOI: 10.1016/j.iccl.2024.11.013.Peer-Reviewed Original ResearchConceptsVenous insufficiencyHistory of deep vein thrombosisVaricose veinsPositive family historyDeep vein thrombosisIncompetent superficial veinsChronic venous insufficiencyChronic venous diseaseElimination of varicose veinsCatheter-based techniquesVein recanalizationAssociated with poor qualityVenous obstructionVein thrombosisPharmacological therapyFamily historyVenous diseaseRisk factorsLeg discomfortFemale genderSuperficial veinsLeg ulcersProlonged standingInsufficiencyVeinCombining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study
Mao J, Matheny M, Smolderen K, Mena-Hurtado C, Sedrakyan A, Goodney P. Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study. BMJ Open 2024, 14: e085806. PMID: 39327057, PMCID: PMC11429269, DOI: 10.1136/bmjopen-2024-085806.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataClinical Research NetworkAmputation-free survivalPeripheral vascular interventionsResearch NetworkINSIGHT Clinical Research NetworkNew York CityHealth record dataIncreased riskLong-term outcomes of interventionsSecondary outcome measuresOutcomes of interventionsIncreased risk of deathYork CityRisk of deathObservational cohort studyHealth recordsRegistry dataClinical registryVascular Quality Initiative registryCohort studyOutcome assessmentRecord dataLong-term outcomesAntithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement
Bonaca M, Barnes G, Bauersachs R, Bessada Y, Conte M, Dua A, Hess C, Serhal M, Mena-Hurtado C, Weitz J, Beckman J. Antithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement. Journal Of The American College Of Cardiology 2024, 84: 936-952. PMID: 39197984, DOI: 10.1016/j.jacc.2024.06.027.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseAntithrombotic strategiesArtery diseaseResponse to antithrombotic therapyLimb eventsRisk of bleedingCoronary artery diseaseAdverse limb eventsAntithrombotic therapyMultidisciplinary working groupClinical scenariosPatientsAssessment of benefit-riskBenefit-riskAnticoagulationDiseaseScientific statementPatient-centeredBleedingReply Errors and Misinterpretation of Society for Vascular Surgery’s Vascular Quality Initiative Registry Data
Smolderen K, Romain G, Mao J, Goodney P, Mena-Hurtado C. Reply Errors and Misinterpretation of Society for Vascular Surgery’s Vascular Quality Initiative Registry Data. JACC Cardiovascular Interventions 2024, 17: 1513. PMID: 38925757, DOI: 10.1016/j.jcin.2024.05.006.Peer-Reviewed Original ResearchLong‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention
Callegari S, Romain G, Cleman J, Scierka L, Jacque F, Smolderen K, Mena‐Hurtado C. Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention. Journal Of The American Heart Association 2024, 13: e034477. PMID: 38761075, PMCID: PMC11179837, DOI: 10.1161/jaha.124.034477.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaPeripheral vascular interventionsHealth careLimb-threatening ischemiaMortality predictorsLong-term mortality riskMultidimensional risk factorsBody mass indexLong-term mortality predictorsImprove individualized careVascular interventionsIndividualized careAssisted careBiopsychosocial modelMortality riskCareMass indexRisk factorsMedical comorbiditiesRisk profileInterventionMortality rateChronic kidney diseaseMortalityPredictive variablesExamining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease
Grubman S, Algara M, Smolderen K, Luna P, Walenczyk K, Scierka L, Cleman J, Siddiqui W, Romain G, Mena‐Hurtado C. Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease. Journal Of The American Heart Association 2024, 13: e030710. PMID: 38166496, PMCID: PMC10863818, DOI: 10.1161/jaha.123.030710.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsMicrovascular diseaseMinor amputationHospital mortalityCardiac eventsArtery diseaseNational Readmission DatabaseFurther prospective researchNumber of patientsCommon risk factorsMultiple logistic regressionMajor amputationBaseline factorsFinal cohortCox regressionAdverse outcomesPAD groupSecondary diagnosisRisk factorsAnnual admissionsObservational studyPrevalent conditionHigh risk
2023
Artificial Intelligence, Computational Simulations, and Extended Reality in Cardiovascular Interventions
Samant S, Bakhos J, Wu W, Zhao S, Kassab G, Khan B, Panagopoulos A, Makadia J, Oguz U, Banga A, Fayaz M, Glass W, Chiastra C, Burzotta F, LaDisa J, Iaizzo P, Murasato Y, Dubini G, Migliavacca F, Mickley T, Bicek A, Fontana J, West N, Mortier P, Boyers P, Gold J, Anderson D, Tcheng J, Windle J, Samady H, Jaffer F, Desai N, Lansky A, Mena-Hurtado C, Abbott D, Brilakis E, Lassen J, Louvard Y, Stankovic G, Serruys P, Velazquez E, Elias P, Bhatt D, Dangas G, Chatzizisis Y. Artificial Intelligence, Computational Simulations, and Extended Reality in Cardiovascular Interventions. JACC Cardiovascular Interventions 2023, 16: 2479-2497. PMID: 37879802, DOI: 10.1016/j.jcin.2023.07.022.Peer-Reviewed Original ResearchConceptsArtificial intelligenceExtended realityVirtual clinical trialsComputer scientistsComputational technologiesIntelligenceMedical technology innovatorsTechnology innovatorsComputational simulationsTechnologyRealityApplicationsBiomedical engineersBioinformaticsSimulationsDevice industryVisualizationConstraintsEngineersExpertsRecent advancesPlanningObstaclesThe Vascular Quality Initiative assessment of the Bard Lifestent for the treatment of popliteal artery occlusive disease
Bertges D, Eldrup-Jorgensen J, Eskandari M, Hamdan A, Mena-Hurtado C, Mewissen M, Smith T, Woo E, Cronenwett J, Initiative S. The Vascular Quality Initiative assessment of the Bard Lifestent for the treatment of popliteal artery occlusive disease. Journal Of Vascular Surgery 2023, 78: 1489-1496.e1. PMID: 37648091, DOI: 10.1016/j.jvs.2023.08.122.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationChronic limb-threatening ischemiaTarget vessel revascularizationMajor adverse eventsLimb-threatening ischemiaPopliteal arteryLesion revascularizationMajor amputationVessel revascularizationHemodynamic successSecondary patencyAdverse eventsOcclusive diseaseProcedural successSingle-arm prospective studyProximal popliteal arterySustained clinical successPrimary efficacy outcomePrimary safety outcomeArtery occlusive diseaseComposite primary endpointPrimary-assisted patencyKaplan-Meier analysisSuperficial femoral arteryMajority of stentsRepresentativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines
Castro-Dominguez Y, Mena-Hurtado C, Algara M, Obas V, Ahmed Z, Romain G, Solaru K, Smolderen K. Representativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines. The American Journal Of Cardiology 2023, 201: 166-169. PMID: 37385170, DOI: 10.1016/j.amjcard.2023.05.053.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD guidelinesArtery diseaseRecent American Heart Association/American CollegeAmerican Heart Association/American CollegeLower extremity peripheral artery diseaseOlder adult patientsRace/ethnicity distributionAdult patientsPooled proportionMean ageClinical trialsCurrent guidelinesEpidemiologic studiesAmerican CollegeTrial participantsRCTsEthnicity distributionOlder adultsTrialsWomenPatientsDiseaseGuidelinesEthnic groupsHealth Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Allison M, Armstrong D, Goodney P, Hamburg N, Kirksey L, Lancaster K, Mena-Hurtado C, Misra S, Treat-Jacobson D, Solaru K, Health O. Health Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 286-296. PMID: 37317860, PMCID: PMC11520198, DOI: 10.1161/cir.0000000000001153.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseClinical effectsAmerican Heart AssociationMajor limb amputationCerebrovascular eventsHeart AssociationHigh prevalenceLimb amputationHealth disparitiesInequitable deliveryInequitable burdenScientific statementHigh rateCertain demographic groupsDiseasePotential novel solutionIndividual disabilityOverview statementDemographic groupsAmputationDisparitiesPrevalenceCareStructural inequitiesThe problem of disparities in vascular health
Castro-Dominguez Y, Smolderen K, Mena-Hurtado C. The problem of disparities in vascular health. Vascular Medicine 2023, 28: 179-181. PMID: 37293740, DOI: 10.1177/1358863x231178044.Peer-Reviewed Original ResearchObesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease
Scierka L, Peri-Okonny P, Romain G, Mena-Hurtado C, Smolderen K. Obesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease. Obesity Research & Clinical Practice 2023, 17: 264-268. PMID: 37225553, DOI: 10.1016/j.orcp.2023.05.002.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseWeight loss medicationsObesity management strategiesMedian odds ratioDietary counselingLower extremity peripheral arterial diseaseSymptomatic peripheral artery diseaseDietary management strategiesSymptomatic PAD patientsPeripheral artery diseaseObesity prevalence ratesPrevalence of obesityPoor disease outcomeModifiable comorbiditiesPORTRAIT registryPAD patientsArtery diseaseArterial diseaseTreatment modalitiesObesity prevalenceOdds ratioDisease outcomePrevalence ratesPAD managementObesityComparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groups
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