2025
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid A, Yatim N, Boumelha J, Azimi C, LaMarche N, Troncoso L, Amabile A, Le Berichel J, Chen S, Wilk C, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer. Nature Immunology 2025, 26: 188-199. PMID: 39838105, DOI: 10.1038/s41590-024-02065-8.Peer-Reviewed Original ResearchConventional dendritic cellsNiemann-Pick disease type C1Maturation of conventional dendritic cellsExpression of maturation markersCholesterol mobilizationAnti-tumor immunityReceptor tyrosine kinase AXLDendritic cell maturationResponse to cancerTyrosine kinase AXLDendritic cellsImmune receptor signalingMaturation markersAuto-immunityCell maturationReceptor signalingImmunogenic responseTherapeutic targetCholesterol transportLipid nanodomainsSubcellular mechanismsCholesterolType C1CancerCell surface
2022
Regulation of bone homeostasis by MERTK and TYRO3
Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu T, Beitzen-Heineke A, Vargas-Delgado M, Pantel K, Bokemeyer C, Bhamidipati S, Darwish I, Masuda E, Burstyn-Cohen T, Alberto E, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Regulation of bone homeostasis by MERTK and TYRO3. Nature Communications 2022, 13: 7689. PMID: 36509738, PMCID: PMC9744875, DOI: 10.1038/s41467-022-33938-x.Peer-Reviewed Original ResearchConceptsCancer-induced bone lossBone homeostasisBone lossBone-resorbing osteoclastsBone metastasesProlong survivalOsteoanabolic therapyMultiple myelomaLung cancerBone-forming osteoblastsBone massHealthy micePreclinical modelsOsteoblast numberMerTKTyro3Bone formationMicePotent regulatorCell type-specific functionsFine equilibriumBlockadeCancerHomeostasisOsteoblast differentiation
2015
TAM Receptor Signaling in Immune Homeostasis
Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM Receptor Signaling in Immune Homeostasis. Annual Review Of Immunology 2015, 33: 1-37. PMID: 25594431, PMCID: PMC4491918, DOI: 10.1146/annurev-immunol-032414-112103.BooksConceptsImmune homeostasisTAM receptor signalingFunction of TAMsResolution of inflammationInnate immune responseTAM receptor tyrosine kinasesImmune settingsAutoimmune diseasesImmune responseInfectious diseasesVascular integrityReceptor tyrosine kinasesReceptor signalingDiseaseApoptotic cellsTyrosine kinaseNegative regulationRecent studiesFunctional importanceHomeostasisEssential roleInflammationCancerAxlMerTK
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