2025
Examining our lens: how bias heightens disparities in trauma research
Timmer-Murillo S, Stadeli K, Higgins J, Strong B, Rakhit S, Fram B, Hall G, Robles A, Soltani T, Callcut R, Ho V, Villarreal C, Price M, Cronn S, Betzold R, Bixby P, Buehner M, Callcut R, Castañón L, Cronn S, de Moya M, Duchesne J, Fakhry S, Fram B, Hall G, Higgins J, Ho V, Jain A, Levi B, Moreno A, Pierrie S, Price M, Rakhit S, Robles A, Sims C, Soltani T, Stadeli K, Strong B, Swain S, Timmer-Murillo S, Tseng E, Villarreal C, West M, Zakrison T. Examining our lens: how bias heightens disparities in trauma research. Trauma Surgery & Acute Care Open 2025, 10: e001452. PMID: 40584750, PMCID: PMC12198817, DOI: 10.1136/tsaco-2024-001452.Peer-Reviewed Original ResearchTrauma researchImplicit biasReduce implicit biasInjury preventionSuboptimal careSocioeconomic statusInjury researchPrevention strategiesApplication of findingsEquity researchDisparitiesCareTraumatic injuryAbility statusGroup of peopleMultiple disciplinesTraumaStatusStereotypical beliefsBiasInjuryPracticeDevelopment of researchInterventionEthnicityAccess, delivery and outcomes: the summit on the advancement of Focused Equity Research in Trauma (SAFER-Trauma)
Villarreal C, Price M, Moreno A, Bixby P, Tseng E, Fram B, Strong B, Callcut R, West M, Ho V. Access, delivery and outcomes: the summit on the advancement of Focused Equity Research in Trauma (SAFER-Trauma). Trauma Surgery & Acute Care Open 2025, 10: e001430. PMID: 40589977, PMCID: PMC12207175, DOI: 10.1136/tsaco-2024-001430.Peer-Reviewed Original ResearchAgency for Healthcare Research and QualityHealthcare Research and QualityTrauma researchEquity researchTrauma program managersInjury careIn-personAmerican CollegeResearch equityTrauma surgeonsVirtual attendeesDisparitiesProgram managersThought leadersTopic areasConference websiteEquitySeries of articlesUnified responseConference proceedingsTraumaInnovative solutionsNursesVideo recordingsCareRisk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study
Roytman G, Lahik S, Tommasini S, Wiznia D, Fram B. Risk of Distal Femur Fracture in Antegrade Intramedullary Nail Fixation of Proximal Femur Fractures: A Finite Element Study. Journal Of Orthopaedic Research® 2025 PMID: 40443200, DOI: 10.1002/jor.26113.Peer-Reviewed Original ResearchSingle-leg stanceAntegrade intramedullary nailingTip terminationMaximum stressFinite element modelFinite element studyFemur fracturesDistal femur fracturesExtent of failureElement modelLoading scenariosBody weight loadElement studyIntramedullary nail fixationProximal femur fracturesOsteoporotic femursRisk of peri-implant fractureNail fixationWeight loadingIntramedullary nailingLoadPeri-implant fracturesGeriatric patientsInterprosthetic Femur Fractures: A Multi-Center Retrospective Study.
Landoch S, Foster J, Cannada L, Obremskey W, Will R, Fram B, Mears S, Stambough J, Stronach B, Brown H, Halvorson J, Andring N, Marenghi N, Dehghan N, Huynh T, Ryan S, Guenthner G, Shiinoki A, Fischman J, Rodriguez E, Moreno-Diaz A, Mika A, Chowdry F, Chen A, Zaidi Z, Miller A, Gutbrod J, Hofer E, Quatman C, Dumpe J, Denisiuk M, Sutherland M, Israel H, Matuszewski P, Aneja A. Interprosthetic Femur Fractures: A Multi-Center Retrospective Study. Journal Of Orthopaedic Trauma 2025 PMID: 40333724, DOI: 10.1097/bot.0000000000003003.Peer-Reviewed Original ResearchInterprosthetic femur fracturesFull weight bearingAmbulation statusAssociated with higher risk of mortalityMortality ratePost-operative complicationsPost-operative outcomesAssociated with higher riskTreated with dual platingHigher risk of mortalityReturn to baseline functionFisher's exact testImpact patient outcomesTherapeutic Level IIIRisk of mortalityDual fixationChi-square testSurgical characteristicsMedian ageOperative fixationMedian timeUnivariate analysisExact testPrimary outcomeLevel IIICD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections
Agidigbi T, Fram B, Molloy I, Riedel M, Wiznia D, Oh I. CD177, MYBL2, and RRM2 Are Potential Biomarkers for Musculoskeletal Infections. Clinical Orthopaedics And Related Research® 2025, 483: 1062-1071. PMID: 39915095, PMCID: PMC12106227, DOI: 10.1097/corr.0000000000003402.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsFracture-related infectionRibonucleotide reductase regulatory subunit M2Peripheral blood mononuclear cell levelsPeripheral blood mononuclear cell concentrationsPeriprosthetic joint infectionMusculoskeletal infectionsMonitoring treatment responseDiabetic foot infectionsTreatment responseReceiver operating characteristicPurulent drainageControl groupSerum levelsSinus tractInflammatory markersBlood samplesFoot infectionsInfection groupDiagnostic accuracyTranscriptomic analysis of peripheral blood mononuclear cellsDiagnosis of musculoskeletal infectionsNormalization of inflammatory markersPeripheral blood mononuclear cells of patientsInflammatory conditionsPredictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients?
Seddio A, Vasudevan R, Gouzoulis M, Jabbouri S, Grauer J, Fram B. Predictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients? JAAOS Global Research And Reviews 2025, 9: e24.00246. PMID: 39823200, PMCID: PMC11745856, DOI: 10.5435/jaaosglobal-d-24-00246.Peer-Reviewed Original ResearchConceptsOdds of venous thromboembolismDirect oral anticoagulantsVenous thromboembolismHeightened oddsHFx patientsIncreased odds of VTEPredictors of venous thromboembolismRisk factors of venous thromboembolismIncidence of venous thromboembolismRate of venous thromboembolismAssociated with considerable morbidityAssociated with reduced oddsFactors of venous thromboembolismEffective therapeutic optionIndependent risk factorClinical risk factorsHip fracture patientsRetrospective cohort studyFemur fracture fixationCoagulopathy disordersOral anticoagulantsElixhauser Comorbidity IndexSurgical managementActive cancerDistal femur fracture fixation
2024
Complications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center
Fram B, Chintalapudi N, Davis J, Yu Z, Seymour R, Karunakar M, Collective E, Hsu J, Kempton L, Phelps K, Sims S, Medda S, Odum S, Wally M, Sweeney J, Hickson K, Young C, Kamath P. Complications after low-velocity ballistic femur fractures: a series of 104 patients at a level 1 trauma center. OTA International The Open Access Journal Of Orthopaedic Trauma 2024, 8: e353. PMID: 39703728, PMCID: PMC11654790, DOI: 10.1097/oi9.0000000000000353.Peer-Reviewed Original ResearchRisk of complicationsComplication rateFemur fracturesProphylactic antibioticsDuration of prophylactic antibioticsAssociated with increased risk of complicationsRisk factors of complicationsDeep surgical site infectionAssociated with increased complicationsIncreased risk of complicationsPatients aged 18+ yearsCase of compartment syndromeAcademic level I trauma centerAll-cause complicationsAssociated with increased riskFactors of complicationsHospital length of staySurgical site infectionRate of complicationsLevel I trauma centerLevel 1 trauma centerRate of vascular complicationsStandard of careAged 18+ yearsLength of stayDeep infections after low-velocity ballistic tibia fractures are frequently polymicrobial and recalcitrant
Chintalapudi N, Fram B, Odum S, Seymour R, Karunakar M, , Hsu J, Kempton L, Phelps K, Sims S, Medda S, Sweeney J, Hickson K, Young C, Kamath P. Deep infections after low-velocity ballistic tibia fractures are frequently polymicrobial and recalcitrant. OTA International The Open Access Journal Of Orthopaedic Trauma 2024, 7: e345. PMID: 39363953, PMCID: PMC11449420, DOI: 10.1097/oi9.0000000000000345.Peer-Reviewed Original ResearchBody mass indexDeep infection rateTibia fracturesDeep infectionCephalosporin prophylaxisMass indexMedian body mass indexIsolated organismsFracture-related infectionAssociated with deep infectionLocal antibiotic treatmentSigns of infectionInfection rateAntibiotic prophylaxisSurgical characteristicsIntraoperative culturesPerioperative prophylaxisPolymicrobial infectionsNo significant differenceProphylactic cefazolinAntibiotic treatmentRecalcitrant infectionsTreatment optionsProphylaxisRisk factorsNeurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery
Balboni J, Gianakos A, Fram B, Kregling C, Kermanshahi N, Webber K. Neurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00378. PMCID: PMC11686789, DOI: 10.1177/2473011424s00378.Peer-Reviewed Original ResearchPeripheral nerve blocksComplex regional pain syndromeComplication rateNeurological complicationsNerve blockAnkle surgeryNerve injuryBlock administrationIncidence of postoperative neurological complicationsEvaluated risk of biasNeurological complication rateRegional pain syndromeSecondary outcome measuresPostoperative neurological complicationsMotor nerve dysfunctionRisk of biasInvestigate possible risk factorsReflex sympathetic dystrophyGuillain-Barre syndromeAt-risk patientsPrevalence of comorbid mood disordersNon-randomized studiesFoot dropLevel of conscious sedationLong-lasting symptomsNeurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery
Balboni J, Kermanshahi N, Kregling C, Webber K, Tung W, Fram B, Gianakos A. Neurologic Complications Following Peripheral Nerve Block in Foot and Ankle Surgery. JBJS Reviews 2024, 12: e24.00081. DOI: 10.2106/jbjs.rvw.24.00081.Peer-Reviewed Original ResearchPeripheral nerve blocksAnkle surgeryNeurological complicationsComplication rateNerve blockNerve injuryDescription of levels of evidenceMotor nerve dysfunctionIncidence of postoperative neurological complicationsLevel of evidenceRisk of nerve injuryLong-lasting symptomsPostoperative neurological complicationsPatient-specific factorsMotor compromiseAnkleChronic painPrimary outcomePregnant populationScreening protocolLevel of sedationTransient paresthesiaNerve deficitsNerve dysfunctionBlock administrationThe synthes femoral neck system (FNS): a technical tip and case series
Salameh M, Fram B. The synthes femoral neck system (FNS): a technical tip and case series. European Journal Of Orthopaedic Surgery & Traumatology 2024, 34: 3373-3376. PMID: 39073600, DOI: 10.1007/s00590-024-04053-y.Peer-Reviewed Original ResearchDo Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?
Fram B, Bosse M, Odum S, Reider L, Gary J, Gordon W, Teague D, Alkhoury D, MacKenzie E, Seymour R, Karunakar M. Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma? Journal Of Bone And Joint Surgery 2024, 106: 776-781. PMID: 38512987, DOI: 10.2106/jbjs.23.00878.Peer-Reviewed Original ResearchConceptsShort Musculoskeletal Function AssessmentTranstibial amputationDistal amputationMidfoot amputationSevere lower-extremity injuriesLower-extremity injuriesLower-limb injuriesMusculoskeletal Function AssessmentPatient-reported outcomesMonths post-injuryBrief Pain IndexSevere limb traumaDescription of levels of evidenceTranstibial amputeesLevel of evidenceFoot traumaSMFA scoresAmputation revisionTherapeutic Level IIIYears of ageBother indexMidfootAmputation healingAverage SMFA scoreEmotional statusFinding Your Job in Orthopaedic Trauma: A Survey Revealing the Cold Hard Facts
Davis M, Ishmael C, Fram B, Light J, Obremskey W, Cannada L. Finding Your Job in Orthopaedic Trauma: A Survey Revealing the Cold Hard Facts. Journal Of Orthopaedic Trauma 2024, 38: e120-e125. PMID: 38117574, DOI: 10.1097/bot.0000000000002744.Peer-Reviewed Original ResearchOutcomes of Distal Third Femur Fractures in Patients 18 Years and Older: A Pilot Study
Roytman G, Jabbouri S, O'Marr J, Raghuram A, Beitler B, Irshad S, Fram B, Yoo B, Leslie M, Riedel M, Tommasini S, Wiznia D. Outcomes of Distal Third Femur Fractures in Patients 18 Years and Older: A Pilot Study. Cureus 2024, 16: e55136. PMID: 38558586, PMCID: PMC10979706, DOI: 10.7759/cureus.55136.Peer-Reviewed Original Research
2023
Proximal humerus fractures: Postoperative protocols and factors affecting treatment decisions among shoulder and elbow and orthopedic trauma surgeons
Fram B, Strony J, Chen R, Namdari S, Krieg J. Proximal humerus fractures: Postoperative protocols and factors affecting treatment decisions among shoulder and elbow and orthopedic trauma surgeons. Journal Of Orthopaedics 2023, 49: 75-80. PMID: 38130473, PMCID: PMC10730336, DOI: 10.1016/j.jor.2023.11.062.Peer-Reviewed Original ResearchOpen reduction internal fixationProximal humerus fracturesRange of motionPostoperative protocolReduction internal fixationIntramedullary nailingOrthopaedic traumaWeight bearingInternal fixationFunctional declineAcute proximal humerus fracturesStandard postoperative protocolTreatment of PHFUpper extremity injuriesPostoperative weight bearingOrthopaedic trauma surgeonsPolytraumatized patientsHumerus fracturesSurgical outcomesTreatment modalitiesExtremity injuriesTreatment decisionsShoulder arthroplastyTrauma surgeonsDaily livingOrthopedic Sub-Specialties Vary in Representation of Female Fellowship Program Directors
Fram B, Kazley J, Cannada L. Orthopedic Sub-Specialties Vary in Representation of Female Fellowship Program Directors. Journal Of Orthopaedic Experience & Innovation 2023, 4 DOI: 10.60118/001c.75452.Peer-Reviewed Original ResearchFemale program directorsProgram director genderFellowship program directorsProgram directorsFellowship positionsDirector genderFemale representationOrthopedic oncologyWomen's decisionsH-indicesMethods DataOrthopedic subspecialtiesLow female representationPediatric orthopedicsStatistical significanceFellowship programsProgram dataFemale leadershipSub-specialtySubspecialtyAcademic rankSubspecialitiesDirectorsP-valueTraining positions
2022
Optimal Position of the Bone Anchor for the Internal Brace Suspensionplasty Technique for Thumb Basal Joint Arthroplasty
Hozack B, Liss F, Fram B, Rivlin M, Ilyas A, Jones C. Optimal Position of the Bone Anchor for the Internal Brace Suspensionplasty Technique for Thumb Basal Joint Arthroplasty. The Journal Of Hand Surgery 2022, 49: 380.e1-380.e6. PMID: 36100487, DOI: 10.1016/j.jhsa.2022.08.001.Peer-Reviewed Original ResearchImpact of an Educational Intervention on the Opioid Knowledge and Prescribing Behaviors of Resident Physicians
Acharya PP, Fram BR, Adalbert JR, Oza A, Palvannan P, Nardone E, Caltabiano N, Liao J, Ilyas AM, ILYAS A. Impact of an Educational Intervention on the Opioid Knowledge and Prescribing Behaviors of Resident Physicians. Cureus 2022, 14: e23508. PMID: 35494931, PMCID: PMC9038586, DOI: 10.7759/cureus.23508.Peer-Reviewed Original ResearchInternal medicine residentsGeneral surgery residentsPain managementResident physiciansEducational interventionPrescribing habitsOpioid epidemicGeneral surgeryEmergency medicineAcute migraine managementArthritic joint painSurgery residentsFirst-line treatmentMedicine residentsResident physician educationChi-squared analysisJoint painSleeve gastrectomyLaparoscopic cholecystectomyMigraine managementPrescribing behaviorEmergency medicine residentsPhysician educationSignificant improvementInternal medicineSurvivorship, complications, and outcomes following distal femoral arthroplasty for non-neoplastic indications
Sobol KR, Fram BR, Strony JT, Brown SA. Survivorship, complications, and outcomes following distal femoral arthroplasty for non-neoplastic indications. Bone & Joint Open 2022, 3: 173-181. PMID: 35227074, PMCID: PMC8965790, DOI: 10.1302/2633-1462.33.bjo-2021-0202.r1.Peer-Reviewed Original ResearchDistal femoral arthroplastyPeriprosthetic joint infectionNon-neoplastic indicationsDistal femoral bone lossNon-oncological causesFemoral bone lossImplant survivorshipBone lossFemoral arthroplastyAseptic looseningHigher overall complication ratePeriprosthetic distal femur fracturesSingle-stage exchangeOverall complication rateDistal femur fracturesPatient demographic dataShort-term survivorshipCommon reoperationMore reoperationsWound complicationsCommon complicationComplication rateRetrospective reviewBone JtJoint infectionFracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings
Goswami K, Tipton C, Clarkson S, Chang G, Tan TL, Fram B, Chisari E, Sobol K, Natoli RM, Conway JD, Altman GT, Parvizi J, Krieg JC. Fracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings. Journal Of Orthopaedic Trauma 2022, 36: s40-s46. PMID: 35061650, DOI: 10.1097/bot.0000000000002305.Peer-Reviewed Original ResearchConceptsPersistent nonunionLong bone nonunionOpen surgical interventionProspective multicenter studySignificant risk factorsAcute fracturesDevastating complicationIntraoperative specimensMulticenter studySurgical interventionFracture nonunionNonunion diagnosisRisk factorsNGS detectionNonunionUseful adjunctFracture healingClinical specimensPatientsClinical implicationsLevel IIMore casesNGS diagnosticsControl casesBacterial profiles
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