2019
Pulmonary Health and Healthy Aging
Clark B, Roeder N, AkgĂĽn K. Pulmonary Health and Healthy Aging. 2019, 81-92. DOI: 10.1007/978-3-030-06200-2_8.ChaptersLung functionLung diseaseOlder adultsAvoidance of smokingChronic lung diseaseLung cancer screeningSkeletal muscle weaknessPulmonary agingAirway functionRespiratory symptomsPulmonary healthMuscle weaknessLung healthCancer screeningMucociliary clearanceWeight managementPhysical activityScarring processProper dietExact causeHealthy agingEnvironmental exposuresElastic recoilAgeLung
2018
Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium
Kalinowski A, Galen B, Ueki I, Sun Y, Mulenos A, Osafo-Addo A, Clark B, Joerns J, Liu W, Nadel J, Dela Cruz C, Koff J. Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium. Mucosal Immunology 2018, 11: 958-967. PMID: 29411775, PMCID: PMC6431552, DOI: 10.1038/mi.2017.120.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusEpidermal growth factor receptorEGFR inhibitionGrowth factor receptorRSV infectionSyncytial virusViral infectionRegulatory factor 1Lower respiratory tract infectionsIFN-λ productionRespiratory tract infectionsChronic lung diseaseFactor receptorAntiviral immune responseFactor 1RSV F proteinType III IFNsAntiviral defenseEGFR activationInnate antiviral responseInterferon regulatory factor 1Cause pneumoniaRSV inducesSignificant IFNTyrosine kinase receptors
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